Effects of the 5HT2C antagonist SB242084 on the pramipexole-induced potentiation of water contrafreeloading, a putative animal model of compulsive behavior

Rationale In rats, quinpirole, a dopaminergic D2/D3 receptor agonist, elicits both hyperdipsia and water “contrafreeloading” (CFL), a putative model of compulsivity. The role of D3 receptors in this effect remains unclear. Clomipramine (CIM) was found to contrast both hyperdipsia and CFL, but the ro...

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Veröffentlicht in:	Psychopharmacology 2013-05, Vol.227 (1), p.55-66
Hauptverfasser:	Schepisi, Chiara, De Carolis, Lorenza, Nencini, Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyridines - pharmacology Aminopyridines - therapeutic use Animals Behavior Benzothiazoles - toxicity Biomedical and Life Sciences Biomedicine Clomipramine Compulsive Behavior - chemically induced Compulsive Behavior - drug therapy Compulsive Behavior - psychology Disease Models, Animal Dopamine Agonists - toxicity Dopamine receptors Drinking - drug effects Drinking - physiology Indoles - pharmacology Indoles - therapeutic use Male Neurosciences Obsessive-compulsive disorder Original Investigation Pharmacology/Toxicology Physiological aspects Properties Psychiatry Psychopharmacology Psychosis Psychotropic drugs Random Allocation Rats Rats, Sprague-Dawley Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - physiology Reinforcement Schedule Serotonin 5-HT2 Receptor Antagonists - pharmacology Serotonin 5-HT2 Receptor Antagonists - therapeutic use Treatment Outcome
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