Glycan-based DC-SIGN targeting vaccines to enhance antigen cross-presentation

► Leb and LeX glycans achieve an efficient antigen-targeting to DCs through DC-SIGN. ► Glycan multivalency is a necessary condition for efficient targeting. ► DC-SIGN targeting results in robust CD4+ and CD8+ T cell responses. Dendritic cells are the most efficient professional antigen-presenting ce...

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Veröffentlicht in:	Molecular immunology 2013-09, Vol.55 (2), p.143-145
Hauptverfasser:	van Kooyk, Yvette, Unger, Wendy W.J., Fehres, Cynthia M., Kalay, Hakan, García-Vallejo, Juan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen Presentation CD8-Positive T-Lymphocytes - immunology Cell Adhesion Molecules - immunology Cell surface molecules Cross-Priming DC-SIGN Dendritic cells Dendritic Cells - immunology Glycans Human Humans Lectins, C-Type - immunology Mice Polysaccharides - immunology Receptors, Cell Surface - immunology Receptors, Pattern Recognition - immunology Rodent Skin Vaccines - immunology
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