Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus
Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for evaluation in animals. ► Virus with restored complex can induce. ► 10-fold higher neutralizing antibodies. ► Peak titers post vaccination within 2...
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| Veröffentlicht in: | Vaccine 2012-12, Vol.30 (52), p.7469-7474 |
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| container_end_page | 7474 |
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| container_issue | 52 |
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| container_title | Vaccine |
| container_volume | 30 |
| creator | Fu, Tong-Ming Wang, Dai Freed, Daniel C Tang, Aimin Li, Fengsheng He, Xi Cole, Suzanne Dubey, Sheri Finnefrock, Adam C ter Meulen, Jan Shiver, John W Casimiro, Danilo R |
| description | Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for evaluation in animals. ► Virus with restored complex can induce. ► 10-fold higher neutralizing antibodies. ► Peak titers post vaccination within 2–4-fold of those in HCMV positive subjects. |
| doi_str_mv | 10.1016/j.vaccine.2012.10.053 |
| format | Article |
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All rights reserved.</rights><rights>Copyright Elsevier Limited Dec 14, 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c571t-ad111601be5d144daf5e4a4b4b021a32d5ff5dfd4409deb95e4b7b57a74829d13</citedby><cites>FETCH-LOGICAL-c571t-ad111601be5d144daf5e4a4b4b021a32d5ff5dfd4409deb95e4b7b57a74829d13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X12014995$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23107592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Tong-Ming</creatorcontrib><creatorcontrib>Wang, Dai</creatorcontrib><creatorcontrib>Freed, Daniel C</creatorcontrib><creatorcontrib>Tang, Aimin</creatorcontrib><creatorcontrib>Li, Fengsheng</creatorcontrib><creatorcontrib>He, Xi</creatorcontrib><creatorcontrib>Cole, Suzanne</creatorcontrib><creatorcontrib>Dubey, Sheri</creatorcontrib><creatorcontrib>Finnefrock, Adam C</creatorcontrib><creatorcontrib>ter Meulen, Jan</creatorcontrib><creatorcontrib>Shiver, John W</creatorcontrib><creatorcontrib>Casimiro, Danilo R</creatorcontrib><title>Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for evaluation in animals. ► Virus with restored complex can induce. ► 10-fold higher neutralizing antibodies. ► Peak titers post vaccination within 2–4-fold of those in HCMV positive subjects.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Cloning</subject><subject>conception</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus - immunology</subject><subject>Cytomegalovirus - physiology</subject><subject>Cytomegalovirus Vaccines - administration & dosage</subject><subject>Cytomegalovirus Vaccines - immunology</subject><subject>epithelial cells</subject><subject>Epithelial Cells - virology</subject><subject>Female</subject><subject>glycoproteins</subject><subject>Human cytomegalovirus</subject><subject>Human herpesvirus 5</subject><subject>immune response</subject><subject>Immunogenicity</subject><subject>Infections</subject><subject>Macaca mulatta</subject><subject>maternal immunity</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>monkeys</subject><subject>Mutation</subject><subject>neutralization</subject><subject>neutralizing antibodies</subject><subject>Neutralizing antibody</subject><subject>Pentameric gH complex</subject><subject>Proteins</subject><subject>Rabbits</subject><subject>seroprevalence</subject><subject>Studies</subject><subject>T-lymphocytes</subject><subject>vaccination</subject><subject>Vaccine</subject><subject>Vaccines</subject><subject>Viral epithelial tropism</subject><subject>Viral infections</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - metabolism</subject><subject>Viral Tropism</subject><subject>virion</subject><subject>virus replication</subject><subject>Viruses</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks1u1DAQxyMEokvhEQBLXHrJ4nHsTXIBoap8SJWQKJW4WRN7suslibd2smhfgyfG0S4g9dKTR-Pf_Oczy14CXwKH1dvtco_GuIGWgoNIviVXxaNsAVVZ5EJB9ThbcLGSuQT-4yx7FuOW84RA_TQ7EwXwUtVikf3-RnH0AUfnB-ZbtncBO0Y7N26oc8kcg9-52DPX74LfU0xGPw1-TYMzbjwwN7CATePGyHCwLGwoTpH1aPBuSnTrA0P2a-M7mrXnLKe652ybqceBmcPoe1pj5xMxxefZkxa7SC9O73l2-_Hq--Xn_Prrpy-XH65zo0oYc7QAsOLQkLIgpcVWkUTZyIYLwEJY1bbKtlZKXltq6vTblI0qsZSVqC0U59nFUTc1Ntc66t5FQ12HA_kpaihkJauy5OJhVAio0swLldA399Ctn8KQGtGwEqqqQJYzpY6UCT7GQK3eBddjOGjget6v3urTnPS839mdlpfiXp3Up6Yn-y_q70IT8PoItOg1roOL-vYmKSjOoawKkIl4fyQozXbvKOhoHA2GrAtkRm29e7CId_cUTOfSOWD3kw4U__ero9Bc38xnOF8hJBFZ16r4A8Ee2jU</recordid><startdate>20121214</startdate><enddate>20121214</enddate><creator>Fu, Tong-Ming</creator><creator>Wang, Dai</creator><creator>Freed, Daniel C</creator><creator>Tang, Aimin</creator><creator>Li, Fengsheng</creator><creator>He, Xi</creator><creator>Cole, Suzanne</creator><creator>Dubey, Sheri</creator><creator>Finnefrock, Adam C</creator><creator>ter Meulen, Jan</creator><creator>Shiver, John W</creator><creator>Casimiro, Danilo R</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20121214</creationdate><title>Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus</title><author>Fu, Tong-Ming ; Wang, Dai ; Freed, Daniel C ; Tang, Aimin ; Li, Fengsheng ; He, Xi ; Cole, Suzanne ; Dubey, Sheri ; Finnefrock, Adam C ; ter Meulen, Jan ; Shiver, John W ; Casimiro, Danilo R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c571t-ad111601be5d144daf5e4a4b4b021a32d5ff5dfd4409deb95e4b7b57a74829d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Neutralizing - 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Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Tong-Ming</au><au>Wang, Dai</au><au>Freed, Daniel C</au><au>Tang, Aimin</au><au>Li, Fengsheng</au><au>He, Xi</au><au>Cole, Suzanne</au><au>Dubey, Sheri</au><au>Finnefrock, Adam C</au><au>ter Meulen, Jan</au><au>Shiver, John W</au><au>Casimiro, Danilo R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2012-12-14</date><risdate>2012</risdate><volume>30</volume><issue>52</issue><spage>7469</spage><epage>7474</epage><pages>7469-7474</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights ► Early vaccines miss a pentameric gH complex important for viral epithelial entry. ► We restored expression of the complex in AD169 virus for evaluation in animals. ► Virus with restored complex can induce. ► 10-fold higher neutralizing antibodies. ► Peak titers post vaccination within 2–4-fold of those in HCMV positive subjects.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23107592</pmid><doi>10.1016/j.vaccine.2012.10.053</doi><tpages>6</tpages></addata></record> |
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| subjects | Allergy and Immunology Animals Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Cloning conception Cytomegalovirus Cytomegalovirus - immunology Cytomegalovirus - physiology Cytomegalovirus Vaccines - administration & dosage Cytomegalovirus Vaccines - immunology epithelial cells Epithelial Cells - virology Female glycoproteins Human cytomegalovirus Human herpesvirus 5 immune response Immunogenicity Infections Macaca mulatta maternal immunity Mice Mice, Inbred BALB C monkeys Mutation neutralization neutralizing antibodies Neutralizing antibody Pentameric gH complex Proteins Rabbits seroprevalence Studies T-lymphocytes vaccination Vaccine Vaccines Viral epithelial tropism Viral infections Viral Proteins - genetics Viral Proteins - metabolism Viral Tropism virion virus replication Viruses |
| title | Restoration of viral epithelial tropism improves immunogenicity in rabbits and rhesus macaques for a whole virion vaccine of human cytomegalovirus |
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