IL10 inversely correlates with the percentage of CD8+ cells in MDS patients
Abstract The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical c...
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| Veröffentlicht in: | Leukemia research 2013-05, Vol.37 (5), p.541-546 |
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| creator | Lopes, Matheus Rodrigues Traina, Fabiola Campos, Paula de Melo Pereira, João Kleber Novais Machado-Neto, João Agostinho Machado, Helymar da Costa Gilli, Simone Cristina Olenscki Saad, Sara Teresinha Olalla Favaro, Patricia |
| description | Abstract The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10 , TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. |
| doi_str_mv | 10.1016/j.leukres.2013.01.019 |
| format | Article |
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CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10 , TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2013.01.019</identifier><identifier>PMID: 23453286</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; CD4-Positive T-Lymphocytes - metabolism ; CD4-Positive T-Lymphocytes - pathology ; CD8+ cells ; CD8-Positive T-Lymphocytes - metabolism ; CD8-Positive T-Lymphocytes - pathology ; CTLA-4 Antigen - blood ; Female ; Forkhead Transcription Factors - blood ; Gene Expression Regulation ; Hematology, Oncology and Palliative Medicine ; Humans ; IL10 ; Immune System ; Interleukin-10 - blood ; Lymphocyte Count ; Male ; Middle Aged ; Myelodysplastic Syndrome ; Myelodysplastic Syndromes - blood ; Myelodysplastic Syndromes - pathology ; Risk Factors ; Transforming Growth Factor beta1 - blood</subject><ispartof>Leukemia research, 2013-05, Vol.37 (5), p.541-546</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-36124707560732b5d3e275bfeabe65450608ad2ade1a8c0619806ea7beb8d6d3</citedby><cites>FETCH-LOGICAL-c500t-36124707560732b5d3e275bfeabe65450608ad2ade1a8c0619806ea7beb8d6d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.leukres.2013.01.019$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23453286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopes, Matheus Rodrigues</creatorcontrib><creatorcontrib>Traina, Fabiola</creatorcontrib><creatorcontrib>Campos, Paula de Melo</creatorcontrib><creatorcontrib>Pereira, João Kleber Novais</creatorcontrib><creatorcontrib>Machado-Neto, João Agostinho</creatorcontrib><creatorcontrib>Machado, Helymar da Costa</creatorcontrib><creatorcontrib>Gilli, Simone Cristina Olenscki</creatorcontrib><creatorcontrib>Saad, Sara Teresinha Olalla</creatorcontrib><creatorcontrib>Favaro, Patricia</creatorcontrib><title>IL10 inversely correlates with the percentage of CD8+ cells in MDS patients</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10 , TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>CD4-Positive T-Lymphocytes - pathology</subject><subject>CD8+ cells</subject><subject>CD8-Positive T-Lymphocytes - metabolism</subject><subject>CD8-Positive T-Lymphocytes - pathology</subject><subject>CTLA-4 Antigen - blood</subject><subject>Female</subject><subject>Forkhead Transcription Factors - blood</subject><subject>Gene Expression Regulation</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>IL10</subject><subject>Immune System</subject><subject>Interleukin-10 - blood</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myelodysplastic Syndrome</subject><subject>Myelodysplastic Syndromes - blood</subject><subject>Myelodysplastic Syndromes - pathology</subject><subject>Risk Factors</subject><subject>Transforming Growth Factor beta1 - blood</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EotvCTwD5iISyzNix41xA1ZZCxSIO7d1ynFnqbTZZ7KRo_z2OduHABUYjzcHvzVjfY-wVwhIB9bvtsqPpIVJaCkC5BMxdP2ELNJUslJHqKVsAlqoQKPQZO09pCwCqxvo5OxOyVFIYvWBfbtYIPPSPFBN1B-6HGKlzIyX-M4z3fLwnvqfoqR_dd-LDhq-uzFvuqetStvGvV7d878aQ39ML9mzjukQvT_OC3V1_vFt9LtbfPt2sLteFVwBjITWKsoJKaaikaFQrSVSq2ZBrSKtSgQbjWuFaQmc8aKwNaHJVQ41pdSsv2Jvj2n0cfkyURrsLaf6Q62mYkkVZmtJUpYT_kAol56qzVB2lPg4pRdrYfQw7Fw8Wwc7E7daeiNuZuAXMPften05MzY7aP67fiLPgw1FAGcljoGiTz7g8tSGSH207hH-eeP_XBt-FPnjXPdCB0naYYp95W7RJWLC3c-xz6ihz4lKB_AW4gqbx</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Lopes, Matheus Rodrigues</creator><creator>Traina, Fabiola</creator><creator>Campos, Paula de Melo</creator><creator>Pereira, João Kleber Novais</creator><creator>Machado-Neto, João Agostinho</creator><creator>Machado, Helymar da Costa</creator><creator>Gilli, Simone Cristina Olenscki</creator><creator>Saad, Sara Teresinha Olalla</creator><creator>Favaro, Patricia</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130501</creationdate><title>IL10 inversely correlates with the percentage of CD8+ cells in MDS patients</title><author>Lopes, Matheus Rodrigues ; Traina, Fabiola ; Campos, Paula de Melo ; Pereira, João Kleber Novais ; Machado-Neto, João Agostinho ; Machado, Helymar da Costa ; Gilli, Simone Cristina Olenscki ; Saad, Sara Teresinha Olalla ; Favaro, Patricia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-36124707560732b5d3e275bfeabe65450608ad2ade1a8c0619806ea7beb8d6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>CD4-Positive T-Lymphocytes - pathology</topic><topic>CD8+ cells</topic><topic>CD8-Positive T-Lymphocytes - metabolism</topic><topic>CD8-Positive T-Lymphocytes - pathology</topic><topic>CTLA-4 Antigen - blood</topic><topic>Female</topic><topic>Forkhead Transcription Factors - blood</topic><topic>Gene Expression Regulation</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>IL10</topic><topic>Immune System</topic><topic>Interleukin-10 - blood</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myelodysplastic Syndrome</topic><topic>Myelodysplastic Syndromes - blood</topic><topic>Myelodysplastic Syndromes - pathology</topic><topic>Risk Factors</topic><topic>Transforming Growth Factor beta1 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes, Matheus Rodrigues</creatorcontrib><creatorcontrib>Traina, Fabiola</creatorcontrib><creatorcontrib>Campos, Paula de Melo</creatorcontrib><creatorcontrib>Pereira, João Kleber Novais</creatorcontrib><creatorcontrib>Machado-Neto, João Agostinho</creatorcontrib><creatorcontrib>Machado, Helymar da Costa</creatorcontrib><creatorcontrib>Gilli, Simone Cristina Olenscki</creatorcontrib><creatorcontrib>Saad, Sara Teresinha Olalla</creatorcontrib><creatorcontrib>Favaro, Patricia</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopes, Matheus Rodrigues</au><au>Traina, Fabiola</au><au>Campos, Paula de Melo</au><au>Pereira, João Kleber Novais</au><au>Machado-Neto, João Agostinho</au><au>Machado, Helymar da Costa</au><au>Gilli, Simone Cristina Olenscki</au><au>Saad, Sara Teresinha Olalla</au><au>Favaro, Patricia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IL10 inversely correlates with the percentage of CD8+ cells in MDS patients</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>37</volume><issue>5</issue><spage>541</spage><epage>546</epage><pages>541-546</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10 , TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23453286</pmid><doi>10.1016/j.leukres.2013.01.019</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD8+ cells CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology CTLA-4 Antigen - blood Female Forkhead Transcription Factors - blood Gene Expression Regulation Hematology, Oncology and Palliative Medicine Humans IL10 Immune System Interleukin-10 - blood Lymphocyte Count Male Middle Aged Myelodysplastic Syndrome Myelodysplastic Syndromes - blood Myelodysplastic Syndromes - pathology Risk Factors Transforming Growth Factor beta1 - blood |
| title | IL10 inversely correlates with the percentage of CD8+ cells in MDS patients |
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