Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

The functional potential of hematopoietic stem cells (HSCs) declines during aging, and in doing so, significantly contributes to hematopoietic pathophysiology in the elderly. To explore the relationship between age-associated HSC decline and the epigenome, we examined global DNA methylation of HSCs...

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Veröffentlicht in:	Cell stem cell 2013-04, Vol.12 (4), p.413-425
Hauptverfasser:	Beerman, Isabel, Bock, Christoph, Garrison, Brian S., Smith, Zachary D., Gu, Hongcang, Meissner, Alexander, Rossi, Derrick J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation Cellular Senescence - genetics DNA Methylation - genetics DNA Replication - genetics Gene Expression Regulation, Developmental Hematopoiesis - genetics Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Male Mice Mice, Inbred C57BL Models, Biological Polycomb Repressive Complex 2 - metabolism Telomere - metabolism
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