Vaccination with Leishmania histone H1-pulsed dendritic cells confers protection in murine visceral leishmaniasis

Visceral leishmaniasis is the most severe form of leishmaniases affecting millions of people worldwide often resulting in death despite optimal therapy. Thus, there is an urgent need for the development of effective anti-infective vaccine(s). In the present study, we evaluated the prophylactic value...

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Veröffentlicht in:	Vaccine 2012-07, Vol.30 (34), p.5086-5093
Hauptverfasser:	Agallou, Maria, Smirlis, Despina, Soteriadou, Ketty P, Karagouni, Evdokia
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antibody Formation Antigens, Protozoan - immunology Bone Marrow Cells - cytology Cell Proliferation CpG ODNs DCs-based vaccine death dendritic cells Dendritic Cells - immunology Female Histone H1 histones Histones - administration & dosage Histones - immunology IFNγ IL-10 IL-12 Immunity, Cellular immunoglobulin G Immunoglobulin G - blood Injections, Intravenous Interferon-gamma - immunology interleukin-10 Interleukin-10 - immunology interleukin-12 Interleukin-12 - immunology interleukin-4 Interleukin-4 - immunology intravenous injection Leishmania Leishmania infantum Leishmania infantum - immunology Leishmania infantum - pathogenicity Leishmaniasis Vaccines - administration & dosage Leishmaniasis Vaccines - immunology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - prevention & control Mice Mice, Inbred BALB C Murine visceral leishmaniasis oligodeoxyribonucleotides Oligonucleotides - immunology people Spleen - immunology Spleen - parasitology vaccination vaccine development vaccines visceral leishmaniasis
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