A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that has been reported to lose function due to genetic alterations in several cancers. WWOX maps to the common chromosomal fragile site FRA16D and several copy number variations (CNVs) were found within this gene. In this study, we inv...

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Veröffentlicht in:	Human molecular genetics 2013-05, Vol.22 (9), p.1886-1894
Hauptverfasser:	Yang, Lei, Liu, Bin, Huang, Binfang, Deng, Jieqiong, Li, Hongbin, Yu, Bolan, Qiu, Fuman, Cheng, Mei, Wang, Hui, Yang, Rongrong, Yang, Xiaorong, Zhou, Yifeng, Lu, Jiachun
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics Case-Control Studies Chromosome Fragile Sites DNA Copy Number Variations Exons Female Genotype Humans Lung Neoplasms - genetics Lung Neoplasms - pathology Male Middle Aged Oxidoreductases - genetics Risk Factors Tumor Suppressor Proteins - genetics WW Domain-Containing Oxidoreductase
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