Cardiac involvement and treatment-related mortality after non-myeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: a retrospective analysis

Summary Background Autologous haemopoietic stem-cell transplantation (HSCT) benefits patients with systemic sclerosis but has been associated with significant treatment-related mortality and failure to improve diffusion capacity of carbon monoxide (DLCO). We aimed to assess efficacy of HSCT and use...

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Veröffentlicht in:	The Lancet (British edition) 2013-03, Vol.381 (9872), p.1116-1124
Hauptverfasser:	Burt, Richard K, Dr, Oliveira, Maria Carolina, MD, Shah, Sanjiv J, MD, Moraes, Daniela A, MD, Simoes, Belinda, MD, Gheorghiade, Mihai, MD, Schroeder, James, MD, Ruderman, Eric, MD, Farge, Dominique, MD, Chai, Z Jessie, BS, Marjanovic, Zora, MD, Jain, Sandeep, MD, Morgan, Amy, NP, Milanetti, Francesca, MD, Han, Xiaoqiang, MD, Jovanovic, Borko, PhD, Helenowski, Irene B, PhD, Voltarelli, Julio, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy autografting Biological and medical sciences Blood Bone marrow, stem cells transplantation. Graft versus host reaction Carbon monoxide cardiac output Cardiovascular diseases Cause of Death Colleges & universities Compassionate Use Trials cyclophosphamide Cytomegalovirus death electrocardiography Epidemiology Female Follow-Up Studies General aspects guidelines heart failure Heart Failure - mortality Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - mortality Humans Hypertension Internal Medicine Kaplan-Meier Estimate lung function Male Medical sciences Mental health Middle Aged Mortality Patients pericarditis Pericarditis, Constrictive - mortality pericardium Peripheral Blood Stem Cell Transplantation - methods Peripheral Blood Stem Cell Transplantation - mortality Public health. Hygiene Public health. Hygiene-occupational medicine pulmonary artery Pulmonary Diffusing Capacity - physiology Quality of life Respiratory function Retrospective Studies risk Scleroderma Scleroderma, Diffuse - mortality Scleroderma, Diffuse - physiopathology Scleroderma, Diffuse - therapy Scleroderma, Limited - mortality Scleroderma, Limited - physiopathology Scleroderma, Limited - therapy sclerosis screening Sepsis - mortality Skin Stem cells Survival Total Lung Capacity Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning Transplantation, Autologous Transplants & implants Ultrasonic imaging Veins & arteries Vital Capacity - physiology Young Adult
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