The effects of IL-17 upon human natural killer cells

► Different forms of IL-17 were tested for their effects on human natural killer cells. ► IL-17A increased NK cell number and cytotoxic function; IL-17D increased the latter. ► IL-17RC was detectable intracellularly in NK cells but not at the cell surface. ► IL-17s have slight stimulatory effects on...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2013-04, Vol.62 (1), p.123-130
Hauptverfasser:	Al Omar, Suliman, Flanagan, Brian F., Almehmadi, Mazen, Christmas, Stephen E.
Format:	Artikel
Sprache:	eng
Schlagworte:	CD3 Complex - metabolism CD56 Antigen - metabolism Cell Count chromium cytokines cytotoxicity Cytotoxicity, Immunologic - drug effects Flow Cytometry Fluorescence genes Granzymes Granzymes - genetics Granzymes - metabolism Humans Interleukin-17 Interleukin-17 - pharmacology K562 Cells Killer Cells, Natural - drug effects Killer Cells, Natural - metabolism Killer Immunoglobulin-like Receptors Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Lymphocyte Activation - drug effects Lysosomal-Associated Membrane Protein 1 - metabolism Natural killer cells Perforin Perforin - genetics Perforin - metabolism phenotype quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction receptors Receptors, KIR - metabolism Receptors, KIR2DL1 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism
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