The zinc-binding fragment of HypA from Helicobacter pylori: a tempting site also for nickel ions

HypA, a nickel accessory protein from H. pylori, binds a zinc ion in it's structural site, a loop with two conserved CXXC motifs (Ac-ELECKDCSHVFKPNALDYGVCEKCHS-NH(2)). There are at least three hypotheses on the binding mode of this ion. In this paper, we try to understand how Zn(2+) binds to th...

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Veröffentlicht in:	Dalton transactions : an international journal of inorganic chemistry 2013-05, Vol.42 (17), p.6012-6020
Hauptverfasser:	Rowinska-Zyrek, Magdalena, Potocki, Slawomir, Witkowska, Danuta, Valensin, Daniela, Kozlowski, Henryk
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Bacterial Proteins - chemistry Bacterial Proteins - metabolism Cadmium Carrier Proteins - chemistry Carrier Proteins - metabolism Circular Dichroism Coordination Complexes - chemistry Coordination Complexes - metabolism Helicobacter pylori Helicobacter pylori - metabolism Ions - chemistry Molecular Sequence Data Nickel - chemistry Nickel - metabolism Protein Binding Sequence Alignment Thermodynamics Zinc - chemistry Zinc - metabolism
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