Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea
Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia apere...
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| Veröffentlicht in: | Acta tropica 2013-05, Vol.126 (2), p.164-166 |
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| creator | Monte, Leonardo G. Jorge, Sérgio Xavier, Marina A. Leal, Fernanda M.A. Amaral, Marta G. Seixas, Fabiana K. Dellagostin, Odir A. Hartleben, Cláudia P. |
| description | Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis. |
| doi_str_mv | 10.1016/j.actatropica.2013.02.009 |
| format | Article |
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Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis.</description><identifier>ISSN: 0001-706X</identifier><identifier>EISSN: 1873-6254</identifier><identifier>DOI: 10.1016/j.actatropica.2013.02.009</identifier><identifier>PMID: 23435256</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>animal models ; Animals ; Bacterial Proteins - genetics ; Brazil - epidemiology ; Brazilian guinea pig ; Cavia ; Cavia aperea ; Cricetinae ; DNA, Bacterial - chemistry ; DNA, Bacterial - genetics ; genes ; Genetic Markers ; guinea pigs ; Guinea Pigs - microbiology ; histopathology ; Kidney - microbiology ; Kidney - pathology ; Leptospira interrogans ; Leptospira interrogans serovar icterohaemorrhagiae - classification ; Leptospira interrogans serovar icterohaemorrhagiae - genetics ; Leptospira interrogans serovar icterohaemorrhagiae - isolation & purification ; Leptospira interrogans serovar icterohaemorrhagiae - pathogenicity ; Leptospirosis ; Leptospirosis - epidemiology ; Leptospirosis - microbiology ; Leptospirosis - veterinary ; Mesocricetus ; Minisatellite Repeats - genetics ; Rodent Diseases - epidemiology ; Rodent Diseases - microbiology ; Sequence Analysis, DNA ; serotypes ; Virulence ; Wild rodent ; Zoonoses</subject><ispartof>Acta tropica, 2013-05, Vol.126 (2), p.164-166</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-9d452b17548dd11866af780964e0b0ec0eb84e87755842130ba4442e24d5c4393</citedby><cites>FETCH-LOGICAL-c434t-9d452b17548dd11866af780964e0b0ec0eb84e87755842130ba4442e24d5c4393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.actatropica.2013.02.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23435256$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monte, Leonardo G.</creatorcontrib><creatorcontrib>Jorge, Sérgio</creatorcontrib><creatorcontrib>Xavier, Marina A.</creatorcontrib><creatorcontrib>Leal, Fernanda M.A.</creatorcontrib><creatorcontrib>Amaral, Marta G.</creatorcontrib><creatorcontrib>Seixas, Fabiana K.</creatorcontrib><creatorcontrib>Dellagostin, Odir A.</creatorcontrib><creatorcontrib>Hartleben, Cláudia P.</creatorcontrib><title>Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea</title><title>Acta tropica</title><addtitle>Acta Trop</addtitle><description>Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis.</description><subject>animal models</subject><subject>Animals</subject><subject>Bacterial Proteins - genetics</subject><subject>Brazil - epidemiology</subject><subject>Brazilian guinea pig</subject><subject>Cavia</subject><subject>Cavia aperea</subject><subject>Cricetinae</subject><subject>DNA, Bacterial - chemistry</subject><subject>DNA, Bacterial - genetics</subject><subject>genes</subject><subject>Genetic Markers</subject><subject>guinea pigs</subject><subject>Guinea Pigs - microbiology</subject><subject>histopathology</subject><subject>Kidney - microbiology</subject><subject>Kidney - pathology</subject><subject>Leptospira interrogans</subject><subject>Leptospira interrogans serovar icterohaemorrhagiae - classification</subject><subject>Leptospira interrogans serovar icterohaemorrhagiae - genetics</subject><subject>Leptospira interrogans serovar icterohaemorrhagiae - isolation & purification</subject><subject>Leptospira interrogans serovar icterohaemorrhagiae - pathogenicity</subject><subject>Leptospirosis</subject><subject>Leptospirosis - epidemiology</subject><subject>Leptospirosis - microbiology</subject><subject>Leptospirosis - veterinary</subject><subject>Mesocricetus</subject><subject>Minisatellite Repeats - genetics</subject><subject>Rodent Diseases - epidemiology</subject><subject>Rodent Diseases - microbiology</subject><subject>Sequence Analysis, DNA</subject><subject>serotypes</subject><subject>Virulence</subject><subject>Wild rodent</subject><subject>Zoonoses</subject><issn>0001-706X</issn><issn>1873-6254</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EotPCK4DZsUmwHTs_SzQqUGkQC6jEzrpxbmY8SuJwnYwET49H0yKWlRe2pfN91_Jh7J0UuRSy_HDMwS2wUJi9g1wJWeRC5UI0z9hG1lWRlcro52wjhJBZJcqfV-w6xmO6qcqol-xKFbowypQbdvoaBnTrAMTdASj1Ivk_sPgw8dDzk6d1wGnhO5yXEGdPwP2UGAp7mCKPmA4U1pnfnZPhADgGogPsPSD3MQywYMd7CiPfwskDhxkJ4RV70cMQ8fXDfsPuP93-2H7Jdt8-320_7jKnC71kTaeNamVldN11UtZlCX1Vi6bUKFqBTmBba6yryphaK1mIFrTWCpXuTGpoihv2_tI7U_i1Ylzs6KPDYYAJwxqtLHR9XkY9AZVNqXQldEKbC-ooxEjY25n8CPTbSmHPhuzR_mfIng1ZoWwylLJvHsas7Yjdv-SjkgS8vQA9BAt78tHef08NJtmsTdnIRGwvBKafO3kkG53HyWHnCd1iu-Cf8JC_s9yzBw</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Monte, Leonardo G.</creator><creator>Jorge, Sérgio</creator><creator>Xavier, Marina A.</creator><creator>Leal, Fernanda M.A.</creator><creator>Amaral, Marta G.</creator><creator>Seixas, Fabiana K.</creator><creator>Dellagostin, Odir A.</creator><creator>Hartleben, Cláudia P.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope></search><sort><creationdate>20130501</creationdate><title>Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea</title><author>Monte, Leonardo G. ; Jorge, Sérgio ; Xavier, Marina A. ; Leal, Fernanda M.A. ; Amaral, Marta G. ; Seixas, Fabiana K. ; Dellagostin, Odir A. ; Hartleben, Cláudia P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-9d452b17548dd11866af780964e0b0ec0eb84e87755842130ba4442e24d5c4393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>animal models</topic><topic>Animals</topic><topic>Bacterial Proteins - genetics</topic><topic>Brazil - epidemiology</topic><topic>Brazilian guinea pig</topic><topic>Cavia</topic><topic>Cavia aperea</topic><topic>Cricetinae</topic><topic>DNA, Bacterial - chemistry</topic><topic>DNA, Bacterial - genetics</topic><topic>genes</topic><topic>Genetic Markers</topic><topic>guinea pigs</topic><topic>Guinea Pigs - microbiology</topic><topic>histopathology</topic><topic>Kidney - microbiology</topic><topic>Kidney - pathology</topic><topic>Leptospira interrogans</topic><topic>Leptospira interrogans serovar icterohaemorrhagiae - classification</topic><topic>Leptospira interrogans serovar icterohaemorrhagiae - genetics</topic><topic>Leptospira interrogans serovar icterohaemorrhagiae - isolation & purification</topic><topic>Leptospira interrogans serovar icterohaemorrhagiae - pathogenicity</topic><topic>Leptospirosis</topic><topic>Leptospirosis - epidemiology</topic><topic>Leptospirosis - microbiology</topic><topic>Leptospirosis - veterinary</topic><topic>Mesocricetus</topic><topic>Minisatellite Repeats - genetics</topic><topic>Rodent Diseases - epidemiology</topic><topic>Rodent Diseases - microbiology</topic><topic>Sequence Analysis, DNA</topic><topic>serotypes</topic><topic>Virulence</topic><topic>Wild rodent</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monte, Leonardo G.</creatorcontrib><creatorcontrib>Jorge, Sérgio</creatorcontrib><creatorcontrib>Xavier, Marina A.</creatorcontrib><creatorcontrib>Leal, Fernanda M.A.</creatorcontrib><creatorcontrib>Amaral, Marta G.</creatorcontrib><creatorcontrib>Seixas, Fabiana K.</creatorcontrib><creatorcontrib>Dellagostin, Odir A.</creatorcontrib><creatorcontrib>Hartleben, Cláudia P.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Acta tropica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monte, Leonardo G.</au><au>Jorge, Sérgio</au><au>Xavier, Marina A.</au><au>Leal, Fernanda M.A.</au><au>Amaral, Marta G.</au><au>Seixas, Fabiana K.</au><au>Dellagostin, Odir A.</au><au>Hartleben, Cláudia P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea</atitle><jtitle>Acta tropica</jtitle><addtitle>Acta Trop</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>126</volume><issue>2</issue><spage>164</spage><epage>166</epage><pages>164-166</pages><issn>0001-706X</issn><eissn>1873-6254</eissn><abstract>Leptospirosis is a worldwide zoonotic infection caused by pathogenic Leptospira. Synanthropic rodents are recognized carriers of leptospires; however, the role of wild rodents in the epidemiology of the disease is still incipient. In this work, we describe Leptospira strain isolated from Cavia aperea (Brazilian guinea pig). The isolated strain was characterized by partial rpoB gene sequencing, variable-number tandem-repeats and histopathological analysis. The strain was identified as Leptospira interrogans, serogroup Icterohaemorrhagiae and caused clinical signs of leptospirosis in the hamster model, attesting to its virulence. In conclusion, these findings could be useful for elucidating the epidemiological role of C. aperea in leptospirosis.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23435256</pmid><doi>10.1016/j.actatropica.2013.02.009</doi><tpages>3</tpages></addata></record> |
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| ispartof | Acta tropica, 2013-05, Vol.126 (2), p.164-166 |
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| subjects | animal models Animals Bacterial Proteins - genetics Brazil - epidemiology Brazilian guinea pig Cavia Cavia aperea Cricetinae DNA, Bacterial - chemistry DNA, Bacterial - genetics genes Genetic Markers guinea pigs Guinea Pigs - microbiology histopathology Kidney - microbiology Kidney - pathology Leptospira interrogans Leptospira interrogans serovar icterohaemorrhagiae - classification Leptospira interrogans serovar icterohaemorrhagiae - genetics Leptospira interrogans serovar icterohaemorrhagiae - isolation & purification Leptospira interrogans serovar icterohaemorrhagiae - pathogenicity Leptospirosis Leptospirosis - epidemiology Leptospirosis - microbiology Leptospirosis - veterinary Mesocricetus Minisatellite Repeats - genetics Rodent Diseases - epidemiology Rodent Diseases - microbiology Sequence Analysis, DNA serotypes Virulence Wild rodent Zoonoses |
| title | Molecular characterization of virulent Leptospira interrogans serogroup Icterohaemorrhagiae isolated from Cavia aperea |
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