Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

Small minipigs (Microminipig, registered as a novel variety of pig in Japan) were developed for use in non-clinical pharmacological/toxicological studies for new drug development. To assess the pharmacokinetics of selective substrates of human cytochrome P450s in Microminipigs, caffeine (human P450...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of toxicological sciences 2012/12/01, Vol.37(6), pp.1157-1164
Hauptverfasser:	Mogi, Masayuki, Toda, Akiko, Iwasaki, Kazuhide, Kusumoto, Shogo, Takehara, Hiromi, Shimizu, Makiko, Murayama, Norie, Izumi, Hiroyuki, Utoh, Masahiro, Yamazaki, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Area under the plasma concentration-time curve Bioavailability Biological Availability Caffeine - administration & dosage Caffeine - blood Caffeine - pharmacokinetics Chromatography, Liquid Combination probe Cytochrome P-450 Enzyme System - physiology Drug Combinations Female Humans Injections, Intravenous Liquid chromatography tandem mass spectrometry Male Metoprolol - administration & dosage Metoprolol - blood Metoprolol - pharmacology Midazolam - administration & dosage Midazolam - blood Midazolam - pharmacokinetics Minipig Models, Animal Omeprazole - administration & dosage Omeprazole - blood Omeprazole - pharmacokinetics Substrate Specificity Swine Swine, Miniature Tandem Mass Spectrometry Warfarin - administration & dosage Warfarin - blood Warfarin - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!