Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones<inline-graphic xlink:href="sbox.jpg"/>

Background: Neutrophil extracellular traps (NETs) composed of DNA and proteins form a scaffold in thrombi, supplementing the fibrin matrix. Results: DNA and histones modify the structure of fibrin and render it resistant to mechanical and enzymatic destruction. Conclusion: NET components are essenti...

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Veröffentlicht in:	The Journal of biological chemistry 2013-01, Vol.288, p.6946-6956
Hauptverfasser:	Longstaff, Colin, Varju, Imre, Sotonyi, Peter, Szabo, Laszlo, Krumrey, Michael, Hoell, Armin, Bota, Attila, Varga, Zoltan, Komorowicz, Erzsebet, Kolev, Krasimir
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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