Synthetic oleanane triterpenoids: magic bullets or not?
A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME a...
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| Veröffentlicht in: | Kidney international 2013-05, Vol.83 (5), p.785-787 |
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| creator | Abboud, Hanna E. |
| description | A recent clinical trial in patients with chronic kidney disease (CKD) and diabetic nephropathy demonstrated that bardoxolone methyl (CDDO-ME) increases estimated glomerular filtration rate (eGFR) by an unknown mechanism. The paper by Ding et al. suggests that short-term administration of a CDDO-ME analog increases GFR by increasing glomerular surface area. However, changes in other renal hemodynamic parameters cannot be excluded. Vigorous testing of CDDO-ME and highly purified analogs is warranted to determine their physiology, pharmacology, and efficacy and to exclude serious side effects. |
| doi_str_mv | 10.1038/ki.2013.38 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0085-2538 |
| ispartof | Kidney international, 2013-05, Vol.83 (5), p.785-787 |
| issn | 0085-2538 1523-1755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1347789627 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Angiotensin II - pharmacology Animals Cell Shape - drug effects Glomerular Filtration Rate - drug effects Humans Male Mesangial Cells - drug effects Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology |
| title | Synthetic oleanane triterpenoids: magic bullets or not? |
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