Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: A comparison with ebselen

•Organoselenium compounds efficiently protect endothelial cells against peroxynitrite toxicity.•The cytopropective effect of diphenyl diselenide could be related with its ability to activate the Nrf-2 cognate genes.•Diphenyl diselenide increases the expression and activity of GPx and the GSH content...

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Veröffentlicht in:	Nitric oxide 2013-05, Vol.31, p.20-30
Hauptverfasser:	Bem, Andreza Fabro de, Fiuza, Bianca, Calcerrada, Pablo, Brito, Paula M., Peluffo, Gonzalo, Dinis, Teresa C.P., Trujillo, Madia, Rocha, João B.T., Radi, Rafael, Almeida, Leonor M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Aorta - cytology Aorta - drug effects Aorta - metabolism Apoptosis Apoptosis - drug effects Azoles - pharmacology Benzene Derivatives - pharmacology Cattle Cell Survival - drug effects Diphenyl diselenide Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Glutathione - metabolism Glutathione peroxidase Glutathione Peroxidase - metabolism Intracellular glutathione NF-E2-Related Factor 2 Organoselenium Compounds - pharmacology Peroxynitrite Peroxynitrous Acid - toxicity Protective Agents - pharmacology
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