Pain-relieving effect of a compound isolated from white peony root oral liquid on acute radiation-induced esophagitis
Acute radiation-induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of...
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| Veröffentlicht in: | Molecular medicine reports 2013-06, Vol.7 (6), p.1950-1954 |
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| container_title | Molecular medicine reports |
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| creator | WANG, ZHIYU SHEN, LI LI, XING SHU, XIN SHAN, BAOEN ZHANG, LI GONG, YANJUN DONG, ZHIMING |
| description | Acute radiation-induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief. |
| doi_str_mv | 10.3892/mmr.2013.1427 |
| format | Article |
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The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.</description><identifier>ISSN: 1791-2997</identifier><identifier>EISSN: 1791-3004</identifier><identifier>DOI: 10.3892/mmr.2013.1427</identifier><identifier>PMID: 23588387</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>acute radiation-induced esophagitis ; Administration, Oral ; Anesthetics, Local - pharmacology ; Animals ; Anti-Bacterial Agents - toxicity ; Anti-Inflammatory Agents - pharmacology ; Antigens ; Body weight ; Body Weight - drug effects ; Body Weight - radiation effects ; compound of white peony root oral liquid ; Dexamethasone ; Dexamethasone - pharmacology ; Disease Models, Animal ; Dysphagia ; Esophagitis ; Esophagitis - drug therapy ; Esophagitis - etiology ; Esophagus ; Food ; Gentamicins - toxicity ; Immunohistochemistry ; Lidocaine ; Lidocaine - pharmacology ; Male ; Molecular modelling ; Nervous system ; Paeonia - chemistry ; Pain ; Pain Management ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Roots - chemistry ; Radiation Injuries - complications ; Radiation Injuries - drug therapy ; Radiation therapy ; Rats ; Rats, Wistar ; Rodents ; Studies ; Substance P ; Substance P - metabolism ; X-Rays</subject><ispartof>Molecular medicine reports, 2013-06, Vol.7 (6), p.1950-1954</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-fb3ee81fcfde9bb5439a1c7f491c4c203d8e8f7b46e56fce136668defd9bb5943</citedby><cites>FETCH-LOGICAL-c458t-fb3ee81fcfde9bb5439a1c7f491c4c203d8e8f7b46e56fce136668defd9bb5943</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,5556,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23588387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, ZHIYU</creatorcontrib><creatorcontrib>SHEN, LI</creatorcontrib><creatorcontrib>LI, XING</creatorcontrib><creatorcontrib>SHU, XIN</creatorcontrib><creatorcontrib>SHAN, BAOEN</creatorcontrib><creatorcontrib>ZHANG, LI</creatorcontrib><creatorcontrib>GONG, YANJUN</creatorcontrib><creatorcontrib>DONG, ZHIMING</creatorcontrib><title>Pain-relieving effect of a compound isolated from white peony root oral liquid on acute radiation-induced esophagitis</title><title>Molecular medicine reports</title><addtitle>Mol Med Rep</addtitle><description>Acute radiation-induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.</description><subject>acute radiation-induced esophagitis</subject><subject>Administration, Oral</subject><subject>Anesthetics, Local - pharmacology</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - toxicity</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antigens</subject><subject>Body weight</subject><subject>Body Weight - drug effects</subject><subject>Body Weight - radiation effects</subject><subject>compound of white peony root oral liquid</subject><subject>Dexamethasone</subject><subject>Dexamethasone - pharmacology</subject><subject>Disease Models, Animal</subject><subject>Dysphagia</subject><subject>Esophagitis</subject><subject>Esophagitis - drug therapy</subject><subject>Esophagitis - etiology</subject><subject>Esophagus</subject><subject>Food</subject><subject>Gentamicins - toxicity</subject><subject>Immunohistochemistry</subject><subject>Lidocaine</subject><subject>Lidocaine - pharmacology</subject><subject>Male</subject><subject>Molecular modelling</subject><subject>Nervous system</subject><subject>Paeonia - chemistry</subject><subject>Pain</subject><subject>Pain Management</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Plant Roots - chemistry</subject><subject>Radiation Injuries - complications</subject><subject>Radiation Injuries - drug therapy</subject><subject>Radiation therapy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Studies</subject><subject>Substance P</subject><subject>Substance P - metabolism</subject><subject>X-Rays</subject><issn>1791-2997</issn><issn>1791-3004</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0U1rFTEUBuAgFvuhS7cScFE3ueZjZpIspVgVCrrQ9ZBJTtqUmWSaTCr9983lXrtwdQLnycuBF6H3jO6E0vzzsuQdp0zsWMflK3TGpGZEUNq9Pr651vIUnZdyT-nQ816_Qadc9EoJJc9Q_WVCJBnmAI8h3mLwHuyGk8cG27SsqUaHQ0mz2cBhn9OC_96FDfAKKT7hnFLD2cx4Dg81OJwiNra2fTYumC2kSEJ01bbPUNJ6Z27DFspbdOLNXODdcV6gP9dff199Jzc_v_24-nJDbNerjfhJACjmrXegp6nvhDbMSt9pZjvLqXAKlJdTN0A_eAtMDMOgHHi317oTF-jTIXfN6aFC2cYlFAvzbCKkWkYmOimVYow1-vE_ep9qju26kWnB2z2cD02Rg7I5lZLBj2sOi8lPI6Pjvo-x9THu-xj3fTT_4ZhapwXci_5XQAOXB1BWE11wqbyYlkSoJHQgTPdUPAML6JWZ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>WANG, ZHIYU</creator><creator>SHEN, LI</creator><creator>LI, XING</creator><creator>SHU, XIN</creator><creator>SHAN, BAOEN</creator><creator>ZHANG, LI</creator><creator>GONG, YANJUN</creator><creator>DONG, ZHIMING</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Pain-relieving effect of a compound isolated from white peony root oral liquid on acute radiation-induced esophagitis</title><author>WANG, ZHIYU ; SHEN, LI ; LI, XING ; SHU, XIN ; SHAN, BAOEN ; ZHANG, LI ; GONG, YANJUN ; DONG, ZHIMING</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-fb3ee81fcfde9bb5439a1c7f491c4c203d8e8f7b46e56fce136668defd9bb5943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acute radiation-induced esophagitis</topic><topic>Administration, Oral</topic><topic>Anesthetics, Local - pharmacology</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - toxicity</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Antigens</topic><topic>Body weight</topic><topic>Body Weight - drug effects</topic><topic>Body Weight - radiation effects</topic><topic>compound of white peony root oral liquid</topic><topic>Dexamethasone</topic><topic>Dexamethasone - pharmacology</topic><topic>Disease Models, Animal</topic><topic>Dysphagia</topic><topic>Esophagitis</topic><topic>Esophagitis - drug therapy</topic><topic>Esophagitis - etiology</topic><topic>Esophagus</topic><topic>Food</topic><topic>Gentamicins - toxicity</topic><topic>Immunohistochemistry</topic><topic>Lidocaine</topic><topic>Lidocaine - pharmacology</topic><topic>Male</topic><topic>Molecular modelling</topic><topic>Nervous system</topic><topic>Paeonia - chemistry</topic><topic>Pain</topic><topic>Pain Management</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Plant Roots - chemistry</topic><topic>Radiation Injuries - complications</topic><topic>Radiation Injuries - drug therapy</topic><topic>Radiation therapy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Studies</topic><topic>Substance P</topic><topic>Substance P - metabolism</topic><topic>X-Rays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, ZHIYU</creatorcontrib><creatorcontrib>SHEN, LI</creatorcontrib><creatorcontrib>LI, XING</creatorcontrib><creatorcontrib>SHU, XIN</creatorcontrib><creatorcontrib>SHAN, BAOEN</creatorcontrib><creatorcontrib>ZHANG, LI</creatorcontrib><creatorcontrib>GONG, YANJUN</creatorcontrib><creatorcontrib>DONG, ZHIMING</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular medicine reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, ZHIYU</au><au>SHEN, LI</au><au>LI, XING</au><au>SHU, XIN</au><au>SHAN, BAOEN</au><au>ZHANG, LI</au><au>GONG, YANJUN</au><au>DONG, ZHIMING</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pain-relieving effect of a compound isolated from white peony root oral liquid on acute radiation-induced esophagitis</atitle><jtitle>Molecular medicine reports</jtitle><addtitle>Mol Med Rep</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>7</volume><issue>6</issue><spage>1950</spage><epage>1954</epage><pages>1950-1954</pages><issn>1791-2997</issn><eissn>1791-3004</eissn><abstract>Acute radiation-induced esophagitis (ARIE) is a common complication of radiotherapy. The aim of this study was to clarify the molecular mechanism of pain relief by the compound of white peony root oral liquid (cWPROL) in ARIE. An animal model of ARIE was established and either cWPROL or a mixture of lidocaine, dexamethasone and gentamycin (mLDG) was administered. We indirectly observed rat symptoms of pain by recording the weight of food and the volume of water consumed by the rats, along with changes in body weight. Additionally, the expression levels of substance P (SP) in the esophageal tissues were detected by immunohistochemistry. It was demonstrated that cWPROL was able to release the pain of ARIE by decreasing the expression of SP; this may be one of the molecular mechanisms via which cWPROL induces pain relief.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>23588387</pmid><doi>10.3892/mmr.2013.1427</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | acute radiation-induced esophagitis Administration, Oral Anesthetics, Local - pharmacology Animals Anti-Bacterial Agents - toxicity Anti-Inflammatory Agents - pharmacology Antigens Body weight Body Weight - drug effects Body Weight - radiation effects compound of white peony root oral liquid Dexamethasone Dexamethasone - pharmacology Disease Models, Animal Dysphagia Esophagitis Esophagitis - drug therapy Esophagitis - etiology Esophagus Food Gentamicins - toxicity Immunohistochemistry Lidocaine Lidocaine - pharmacology Male Molecular modelling Nervous system Paeonia - chemistry Pain Pain Management Plant Extracts - pharmacology Plant Extracts - therapeutic use Plant Roots - chemistry Radiation Injuries - complications Radiation Injuries - drug therapy Radiation therapy Rats Rats, Wistar Rodents Studies Substance P Substance P - metabolism X-Rays |
| title | Pain-relieving effect of a compound isolated from white peony root oral liquid on acute radiation-induced esophagitis |
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