Skeletal muscle aging and the mitochondrion
Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed,...
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| Veröffentlicht in: | Trends in endocrinology and metabolism 2013-05, Vol.24 (5), p.247-256 |
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| container_title | Trends in endocrinology and metabolism |
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| creator | Johnson, Matthew L Robinson, Matthew M Nair, K. Sreekumaran |
| description | Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population. |
| doi_str_mv | 10.1016/j.tem.2012.12.003 |
| format | Article |
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Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.</description><identifier>ISSN: 1043-2760</identifier><identifier>EISSN: 1879-3061</identifier><identifier>DOI: 10.1016/j.tem.2012.12.003</identifier><identifier>PMID: 23375520</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Aging ; Animals ; Endocrinology & Metabolism ; Humans ; mitochondria ; Mitochondria, Muscle - enzymology ; Mitochondria, Muscle - metabolism ; Mitochondrial Diseases - metabolism ; Mitochondrial Diseases - physiopathology ; Mitochondrial Dynamics ; Mitochondrial Proteins - metabolism ; Models, Biological ; Muscle Proteins - metabolism ; Muscle, Skeletal - growth & development ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Oxidative Stress ; protein metabolism ; Protein Stability ; protein synthesis ; sarcopenia ; Sarcopenia - etiology ; Sarcopenia - metabolism ; Sarcopenia - pathology ; Signal Transduction</subject><ispartof>Trends in endocrinology and metabolism, 2013-05, Vol.24 (5), p.247-256</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. 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Sreekumaran</creatorcontrib><title>Skeletal muscle aging and the mitochondrion</title><title>Trends in endocrinology and metabolism</title><addtitle>Trends Endocrinol Metab</addtitle><description>Decline in human muscle mass and strength (sarcopenia) is a hallmark of the aging process. A growing body of research in the areas of bioenergetics and protein turnover has placed the mitochondria at the center of this process. It is now clear that, unless an active lifestyle is rigorously followed, skeletal muscle mitochondrial decline occurs as humans age. Increasing research on mitochondrial biology has elucidated the regulatory pathways involved in mitochondrial biogenesis, many of which are potential therapeutic targets, and highlight the beneficial effects of vigorous physical activity on skeletal muscle health for an aging population.</description><subject>Aging</subject><subject>Animals</subject><subject>Endocrinology & Metabolism</subject><subject>Humans</subject><subject>mitochondria</subject><subject>Mitochondria, Muscle - enzymology</subject><subject>Mitochondria, Muscle - metabolism</subject><subject>Mitochondrial Diseases - metabolism</subject><subject>Mitochondrial Diseases - physiopathology</subject><subject>Mitochondrial Dynamics</subject><subject>Mitochondrial Proteins - metabolism</subject><subject>Models, Biological</subject><subject>Muscle Proteins - metabolism</subject><subject>Muscle, Skeletal - growth & development</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Oxidative Stress</subject><subject>protein metabolism</subject><subject>Protein Stability</subject><subject>protein synthesis</subject><subject>sarcopenia</subject><subject>Sarcopenia - etiology</subject><subject>Sarcopenia - metabolism</subject><subject>Sarcopenia - pathology</subject><subject>Signal Transduction</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUlLBDEQhYMo7j_Ai_RRkB4rexpBEHEDwYN6Dpl0zZixF026Bf-9GWb04EEoqDq896C-R8gRhQkFqs4WkwHbCQPKJnkA-AbZpUZXJQdFN_MNgpdMK9gheyktAKgwVG6THca5lpLBLjl9esMGB9cU7Zh8g4Wbh25euK4uhlcs2jD0_rXv6hj67oBszVyT8HC998nLzfXz1V358Hh7f3X5UHoh6VCaGUiGXkyFr5gWhtdOe-2UEdLUoJRRYKg31RRmVE6xEoLJCpFrrStQFef75GSV-x77jxHTYNuQPDaN67Afk6VcaKGkkjpL6UrqY59SxJl9j6F18ctSsEtGdmEzI7tkZPNkRtlzvI4fpy3Wv44fKFlwvhJgfvIzYLTJB-w81iGiH2zdh3_jL_64fRO64F3zhl-YFv0Yu0zPUpuywT4tS1p2RBkAY9zwb8kbiQM</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Johnson, Matthew L</creator><creator>Robinson, Matthew M</creator><creator>Nair, K. 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Sreekumaran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8f052ec4b4c927483da7c7a68458d06686081c89b0f15be944259ee3777906933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Endocrinology & Metabolism</topic><topic>Humans</topic><topic>mitochondria</topic><topic>Mitochondria, Muscle - enzymology</topic><topic>Mitochondria, Muscle - metabolism</topic><topic>Mitochondrial Diseases - metabolism</topic><topic>Mitochondrial Diseases - physiopathology</topic><topic>Mitochondrial Dynamics</topic><topic>Mitochondrial Proteins - metabolism</topic><topic>Models, Biological</topic><topic>Muscle Proteins - metabolism</topic><topic>Muscle, Skeletal - growth & development</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Oxidative Stress</topic><topic>protein metabolism</topic><topic>Protein Stability</topic><topic>protein synthesis</topic><topic>sarcopenia</topic><topic>Sarcopenia - etiology</topic><topic>Sarcopenia - metabolism</topic><topic>Sarcopenia - pathology</topic><topic>Signal Transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Matthew L</creatorcontrib><creatorcontrib>Robinson, Matthew M</creatorcontrib><creatorcontrib>Nair, K. 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| identifier | ISSN: 1043-2760 |
| ispartof | Trends in endocrinology and metabolism, 2013-05, Vol.24 (5), p.247-256 |
| issn | 1043-2760 1879-3061 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aging Animals Endocrinology & Metabolism Humans mitochondria Mitochondria, Muscle - enzymology Mitochondria, Muscle - metabolism Mitochondrial Diseases - metabolism Mitochondrial Diseases - physiopathology Mitochondrial Dynamics Mitochondrial Proteins - metabolism Models, Biological Muscle Proteins - metabolism Muscle, Skeletal - growth & development Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Oxidative Stress protein metabolism Protein Stability protein synthesis sarcopenia Sarcopenia - etiology Sarcopenia - metabolism Sarcopenia - pathology Signal Transduction |
| title | Skeletal muscle aging and the mitochondrion |
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