Treatment of Human Embryonic Stem Cells with Different Combinations of Priming and Inducing Factors Toward Definitive Endoderm

Despite the enormous progress in studying definitive endoderm (DE) differentiation from human embryonic stem cells (hESCs), none of the reported protocols have produced a universal, cost-effective, and competent DE with the capability to further differentiate into endodermal derivatives. In this stu...

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Veröffentlicht in:	Stem cells and development 2013-05, Vol.22 (9), p.1419-1432
Hauptverfasser:	Tahamtani, Yasser, Azarnia, Mahnaz, Farrokhi, Ali, Sharifi-Zarchi, Ali, Aghdami, Nasser, Baharvand, Hossein
Format:	Artikel
Sprache:	eng
Schlagworte:	Activins - pharmacology Activins - physiology Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Cell Differentiation - drug effects Cells, Cultured Embryonic Stem Cells - drug effects Embryonic Stem Cells - physiology Endoderm - cytology Endoderm - metabolism Gene Expression Glycogen - biosynthesis Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - metabolism Humans Liver - cytology Liver - metabolism Original Research Reports Pancreas - cytology Sirolimus - pharmacology SOXF Transcription Factors - genetics SOXF Transcription Factors - metabolism TOR Serine-Threonine Kinases - antagonists & inhibitors
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