Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer
Purpose Although thrombocytosis has been reported in patients with various cancers including the colorectal one, the impact of elevated platelet counts on the response to chemoradiotherapy (CRT) for rectal cancer has not been fully investigated. We investigated the clinical significance of pre- and...
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| Veröffentlicht in: | International journal of colorectal disease 2013-04, Vol.28 (4), p.527-535 |
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| container_title | International journal of colorectal disease |
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| creator | Kawai, Kazushige Kitayama, Joji Tsuno, Nelson H. Sunami, Eiji Watanabe, Toshiaki |
| description | Purpose
Although thrombocytosis has been reported in patients with various cancers including the colorectal one, the impact of elevated platelet counts on the response to chemoradiotherapy (CRT) for rectal cancer has not been fully investigated. We investigated the clinical significance of pre- and post-CRT platelet counts in patients with rectal cancer.
Methods
The medical records of 101 patients with rectal cancer, who had received CRT followed by surgical resection, were retrospectively reviewed. The correlations between the clinicopathological variables and the pre- or post-CRT platelet counts were analyzed. The correlations between tumor regression rate induced by CRT, as evaluated by barium enema and pathological examination, and the pre- or post-CRT platelet counts were also evaluated. Finally, the impact of pre-CRT thrombocytosis on the prognosis of these patients was assessed.
Results
The pre-CRT platelet count correlated with venous invasion and tumor size, and it strongly correlated with the response rate evaluated by barium enema and the grade of pathological tumor regression. Furthermore, patients with pre-CRT thrombocytosis had significantly shorter local recurrence-free survival.
Conclusion
Platelet count before CRT should be a promising biomarker for predicting the efficacy of CRT and the risk of local recurrence in rectal cancer patients after CRT. |
| doi_str_mv | 10.1007/s00384-012-1594-4 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1347256704</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714491095</galeid><sourcerecordid>A714491095</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-7cfd64fcd62a6228e4fc43bc2ff75a76beccee84ecd7ce86ae2df43a1fe465803</originalsourceid><addsrcrecordid>eNp1kc9u1DAQxi0EokvhAbigSFy4pNiOYyfHqgKKVIlLOVvOZNx1lcRhnKy0b8Bj42hL-SOQD56Z7zejGX2MvRb8QnBu3ifOq0aVXMhS1K0q1RO2E6rKmdTyKdtxYdpStHVzxl6kdM9zro16zs5kxRteqXrHvt_uKY5dhOMSU0hFhz4SFjNhGWckt4QDFrDHMZLrQ1z2uTYfN70PsKRijpEKwjTHKWHhpr5I-0gLUjFEcEOWYCXCCbD0hFiklQ7hkIUwbdqSI3BZpZfsmXdDwlcP_zn7-vHD7dV1efPl0-ery5sSal4vpQHfa-Wh19JpKRvMsao6kN6b2hndIQBioxB6A9hoh7L3qnLCo9J1PvqcvTvNnSl-WzEtdgwJcBjchHFNVlTKyFobrjL69i_0Pq405e02SrfSGN3-ou7cgDZMPi7kYBtqL41QqhW8rTN18Q8qvx7HAHFCH3L9jwZxagCKKRF6O1MYHR2t4HZz357ct9l9u7lvt4XfPCy8diP2jx0_7c6APAEpS9Md0m8X_XfqDxV2vT0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346927769</pqid></control><display><type>article</type><title>Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Kawai, Kazushige ; Kitayama, Joji ; Tsuno, Nelson H. ; Sunami, Eiji ; Watanabe, Toshiaki</creator><creatorcontrib>Kawai, Kazushige ; Kitayama, Joji ; Tsuno, Nelson H. ; Sunami, Eiji ; Watanabe, Toshiaki</creatorcontrib><description>Purpose
Although thrombocytosis has been reported in patients with various cancers including the colorectal one, the impact of elevated platelet counts on the response to chemoradiotherapy (CRT) for rectal cancer has not been fully investigated. We investigated the clinical significance of pre- and post-CRT platelet counts in patients with rectal cancer.
Methods
The medical records of 101 patients with rectal cancer, who had received CRT followed by surgical resection, were retrospectively reviewed. The correlations between the clinicopathological variables and the pre- or post-CRT platelet counts were analyzed. The correlations between tumor regression rate induced by CRT, as evaluated by barium enema and pathological examination, and the pre- or post-CRT platelet counts were also evaluated. Finally, the impact of pre-CRT thrombocytosis on the prognosis of these patients was assessed.
Results
The pre-CRT platelet count correlated with venous invasion and tumor size, and it strongly correlated with the response rate evaluated by barium enema and the grade of pathological tumor regression. Furthermore, patients with pre-CRT thrombocytosis had significantly shorter local recurrence-free survival.
Conclusion
Platelet count before CRT should be a promising biomarker for predicting the efficacy of CRT and the risk of local recurrence in rectal cancer patients after CRT.</description><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-012-1594-4</identifier><identifier>PMID: 23080345</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Analysis ; Cancer patients ; Chemoradiotherapy ; Colorectal cancer ; Development and progression ; Disease-Free Survival ; Diseases ; Female ; Follow-Up Studies ; Gastroenterology ; Hepatology ; Humans ; Internal Medicine ; Male ; Medical records ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local - pathology ; Original Article ; Platelet Count ; Preoperative Care ; Proctology ; Prognosis ; Rectal Neoplasms - drug therapy ; Rectal Neoplasms - radiotherapy ; Rectal Neoplasms - surgery ; Rectal Neoplasms - therapy ; Relapse ; Remission Induction ; Sensitivity and Specificity ; Surgery ; Thrombocytosis - complications ; Treatment Outcome</subject><ispartof>International journal of colorectal disease, 2013-04, Vol.28 (4), p.527-535</ispartof><rights>Springer-Verlag Berlin Heidelberg 2012</rights><rights>COPYRIGHT 2013 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-7cfd64fcd62a6228e4fc43bc2ff75a76beccee84ecd7ce86ae2df43a1fe465803</citedby><cites>FETCH-LOGICAL-c505t-7cfd64fcd62a6228e4fc43bc2ff75a76beccee84ecd7ce86ae2df43a1fe465803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00384-012-1594-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00384-012-1594-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23080345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawai, Kazushige</creatorcontrib><creatorcontrib>Kitayama, Joji</creatorcontrib><creatorcontrib>Tsuno, Nelson H.</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><title>Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
Although thrombocytosis has been reported in patients with various cancers including the colorectal one, the impact of elevated platelet counts on the response to chemoradiotherapy (CRT) for rectal cancer has not been fully investigated. We investigated the clinical significance of pre- and post-CRT platelet counts in patients with rectal cancer.
Methods
The medical records of 101 patients with rectal cancer, who had received CRT followed by surgical resection, were retrospectively reviewed. The correlations between the clinicopathological variables and the pre- or post-CRT platelet counts were analyzed. The correlations between tumor regression rate induced by CRT, as evaluated by barium enema and pathological examination, and the pre- or post-CRT platelet counts were also evaluated. Finally, the impact of pre-CRT thrombocytosis on the prognosis of these patients was assessed.
Results
The pre-CRT platelet count correlated with venous invasion and tumor size, and it strongly correlated with the response rate evaluated by barium enema and the grade of pathological tumor regression. Furthermore, patients with pre-CRT thrombocytosis had significantly shorter local recurrence-free survival.
Conclusion
Platelet count before CRT should be a promising biomarker for predicting the efficacy of CRT and the risk of local recurrence in rectal cancer patients after CRT.</description><subject>Analysis</subject><subject>Cancer patients</subject><subject>Chemoradiotherapy</subject><subject>Colorectal cancer</subject><subject>Development and progression</subject><subject>Disease-Free Survival</subject><subject>Diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical records</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Original Article</subject><subject>Platelet Count</subject><subject>Preoperative Care</subject><subject>Proctology</subject><subject>Prognosis</subject><subject>Rectal Neoplasms - drug therapy</subject><subject>Rectal Neoplasms - radiotherapy</subject><subject>Rectal Neoplasms - surgery</subject><subject>Rectal Neoplasms - therapy</subject><subject>Relapse</subject><subject>Remission Induction</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Thrombocytosis - complications</subject><subject>Treatment Outcome</subject><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc9u1DAQxi0EokvhAbigSFy4pNiOYyfHqgKKVIlLOVvOZNx1lcRhnKy0b8Bj42hL-SOQD56Z7zejGX2MvRb8QnBu3ifOq0aVXMhS1K0q1RO2E6rKmdTyKdtxYdpStHVzxl6kdM9zro16zs5kxRteqXrHvt_uKY5dhOMSU0hFhz4SFjNhGWckt4QDFrDHMZLrQ1z2uTYfN70PsKRijpEKwjTHKWHhpr5I-0gLUjFEcEOWYCXCCbD0hFiklQ7hkIUwbdqSI3BZpZfsmXdDwlcP_zn7-vHD7dV1efPl0-ery5sSal4vpQHfa-Wh19JpKRvMsao6kN6b2hndIQBioxB6A9hoh7L3qnLCo9J1PvqcvTvNnSl-WzEtdgwJcBjchHFNVlTKyFobrjL69i_0Pq405e02SrfSGN3-ou7cgDZMPi7kYBtqL41QqhW8rTN18Q8qvx7HAHFCH3L9jwZxagCKKRF6O1MYHR2t4HZz357ct9l9u7lvt4XfPCy8diP2jx0_7c6APAEpS9Md0m8X_XfqDxV2vT0</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Kawai, Kazushige</creator><creator>Kitayama, Joji</creator><creator>Tsuno, Nelson H.</creator><creator>Sunami, Eiji</creator><creator>Watanabe, Toshiaki</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130401</creationdate><title>Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer</title><author>Kawai, Kazushige ; Kitayama, Joji ; Tsuno, Nelson H. ; Sunami, Eiji ; Watanabe, Toshiaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-7cfd64fcd62a6228e4fc43bc2ff75a76beccee84ecd7ce86ae2df43a1fe465803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis</topic><topic>Cancer patients</topic><topic>Chemoradiotherapy</topic><topic>Colorectal cancer</topic><topic>Development and progression</topic><topic>Disease-Free Survival</topic><topic>Diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical records</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Original Article</topic><topic>Platelet Count</topic><topic>Preoperative Care</topic><topic>Proctology</topic><topic>Prognosis</topic><topic>Rectal Neoplasms - drug therapy</topic><topic>Rectal Neoplasms - radiotherapy</topic><topic>Rectal Neoplasms - surgery</topic><topic>Rectal Neoplasms - therapy</topic><topic>Relapse</topic><topic>Remission Induction</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><topic>Thrombocytosis - complications</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawai, Kazushige</creatorcontrib><creatorcontrib>Kitayama, Joji</creatorcontrib><creatorcontrib>Tsuno, Nelson H.</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawai, Kazushige</au><au>Kitayama, Joji</au><au>Tsuno, Nelson H.</au><au>Sunami, Eiji</au><au>Watanabe, Toshiaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2013-04-01</date><risdate>2013</risdate><volume>28</volume><issue>4</issue><spage>527</spage><epage>535</epage><pages>527-535</pages><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purpose
Although thrombocytosis has been reported in patients with various cancers including the colorectal one, the impact of elevated platelet counts on the response to chemoradiotherapy (CRT) for rectal cancer has not been fully investigated. We investigated the clinical significance of pre- and post-CRT platelet counts in patients with rectal cancer.
Methods
The medical records of 101 patients with rectal cancer, who had received CRT followed by surgical resection, were retrospectively reviewed. The correlations between the clinicopathological variables and the pre- or post-CRT platelet counts were analyzed. The correlations between tumor regression rate induced by CRT, as evaluated by barium enema and pathological examination, and the pre- or post-CRT platelet counts were also evaluated. Finally, the impact of pre-CRT thrombocytosis on the prognosis of these patients was assessed.
Results
The pre-CRT platelet count correlated with venous invasion and tumor size, and it strongly correlated with the response rate evaluated by barium enema and the grade of pathological tumor regression. Furthermore, patients with pre-CRT thrombocytosis had significantly shorter local recurrence-free survival.
Conclusion
Platelet count before CRT should be a promising biomarker for predicting the efficacy of CRT and the risk of local recurrence in rectal cancer patients after CRT.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23080345</pmid><doi>10.1007/s00384-012-1594-4</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0179-1958 |
| ispartof | International journal of colorectal disease, 2013-04, Vol.28 (4), p.527-535 |
| issn | 0179-1958 1432-1262 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analysis Cancer patients Chemoradiotherapy Colorectal cancer Development and progression Disease-Free Survival Diseases Female Follow-Up Studies Gastroenterology Hepatology Humans Internal Medicine Male Medical records Medical research Medicine Medicine & Public Health Medicine, Experimental Middle Aged Multivariate Analysis Neoplasm Recurrence, Local - pathology Original Article Platelet Count Preoperative Care Proctology Prognosis Rectal Neoplasms - drug therapy Rectal Neoplasms - radiotherapy Rectal Neoplasms - surgery Rectal Neoplasms - therapy Relapse Remission Induction Sensitivity and Specificity Surgery Thrombocytosis - complications Treatment Outcome |
| title | Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer |
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