Metabolism of endocannabinoids and related N‐acylethanolamines: Canonical and alternative pathways

Endocannabinoids are endogenous ligands of the cannabinoid receptors CB1 and CB2. Two arachidonic acid derivatives, arachidonoylethanolamide (anandamide) and 2‐arachidonoylglycerol, are considered to be physiologically important endocannabinoids. In the known metabolic pathway in mammals, anandamide...

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Veröffentlicht in:	The FEBS journal 2013-05, Vol.280 (9), p.1874-1894
Hauptverfasser:	Ueda, Natsuo, Tsuboi, Kazuhito, Uyama, Toru
Format:	Artikel
Sprache:	eng
Schlagworte:	2‐arachidonoylglycerol Amino Acid Sequence anandamide Animals Arachidonic Acids - metabolism Biosynthetic Pathways Endocannabinoids - metabolism Ethanolamines - metabolism Glycerides - metabolism HRASLS family Humans Hydrolases - chemistry Hydrolases - metabolism Lysophospholipids - metabolism Metabolism Molecular Sequence Data Monoacylglycerol Lipases - chemistry Monoacylglycerol Lipases - metabolism Neurons N‐acyl‐phosphatidylethanolamine phospholipid Phosphoric Diester Hydrolases - chemistry Phosphoric Diester Hydrolases - metabolism Tumors
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