Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions
Background and objective Pentraxin‐3 (PTX‐3) is a relatively new marker of inflammation that has not been previously tested in pleural effusions. We aimed to assess whether PTX‐3 is an accurate biomarker of parapneumonic effusions (PPE) and whether it discriminates complicated (CPPE)from non‐complic...
Gespeichert in:
| Veröffentlicht in: | Respirology (Carlton, Vic.) Vic.), 2013-05, Vol.18 (4), p.657-662 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 662 |
|---|---|
| container_issue | 4 |
| container_start_page | 657 |
| container_title | Respirology (Carlton, Vic.) |
| container_volume | 18 |
| creator | Ozsu, Savas Abul, Yasin Mentese, Ahmet Bektas, Hayriye Uzun, Aysegul Ozlu, Tevfik Porcel, José M. |
| description | Background and objective
Pentraxin‐3 (PTX‐3) is a relatively new marker of inflammation that has not been previously tested in pleural effusions. We aimed to assess whether PTX‐3 is an accurate biomarker of parapneumonic effusions (PPE) and whether it discriminates complicated (CPPE)from non‐complicated PPE.
Methods
The concentrations of pleural fluid PTX‐3 were measured by a commercial enzyme‐linked immunosorbent assay in a prospective cohort of 84 patients with pleural effusions, including 24 PPE, 40 malignant, and 20 miscellaneous exudative effusions. The area under the curve quantified the overall diagnostic accuracy of the test. A multivariate logistic regression analysis selected pleural fluid biochemistries predictive of PPE.
Results
Median pleural fluid PTX‐3 levels were higher in PPE than in both malignant effusions and other exudates (32.4 ng/mL vs 6.7 ng/mL, and 8.5 ng/mL, respectively, P 12 ng/mL yielded 88% sensitivity, 73% specificity, likelihood ratio positive 3.3 and likelihood ratio negative 0.17 for diagnosing PPE, with an area under the curve of 0.855 (95% CI: 0.769–0.941). In the multivariate analysis, pleural PTX‐3 levels remained associated with increased diagnostic odds for PPE (odds ratio 17.7, 95% confidence interval: 3.7–85.1, P |
| doi_str_mv | 10.1111/resp.12038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1346582633</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1346582633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3678-c19e2a1380bc76a4e01b13274b393007d830a0f41e34d8466d205bd3852861f63</originalsourceid><addsrcrecordid>eNp9kM1O3TAQRq2qqPxu-gCVlxVSwM44tm93FMEtEqKogNjVcpJJ6zaxUzuBy9vXcIEls5lZnPk0cwj5yNkBz3UYMY0HvGSg35EtLgQruBbwPs9QQqHUYrFJtlP6wxiDilUfyGYJpZag-Bb5eYl-inblfAFf6BH14Q57Wrsw2PgXI-1CpK1LTXSD83Zy_hcdbbSjx3kI3jW0i2GgYfqdWVzNbUbukGLXzckFn3bJRmf7hHvPfYfcnJ5cH38rzr8vz46PzosGpNJFwxdYWg6a1Y2SViDjdT5eiRoWwJhqNTDLOsERRKuFlG3JqroFXeU_eCdhh3xe544x_JsxTWbIR2PfW49hToaDkJUuJUBG99doE0NKETsz5udsfDCcmUef5tGnefKZ4U_PuXM9YPuKvgjMAF8D967HhzeizI-Tq8uX0GK949KEq9edLNxIBaoytxdLc8WBL6_VVyPgP-Ysjv8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346582633</pqid></control><display><type>article</type><title>Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Ozsu, Savas ; Abul, Yasin ; Mentese, Ahmet ; Bektas, Hayriye ; Uzun, Aysegul ; Ozlu, Tevfik ; Porcel, José M.</creator><creatorcontrib>Ozsu, Savas ; Abul, Yasin ; Mentese, Ahmet ; Bektas, Hayriye ; Uzun, Aysegul ; Ozlu, Tevfik ; Porcel, José M.</creatorcontrib><description>Background and objective
Pentraxin‐3 (PTX‐3) is a relatively new marker of inflammation that has not been previously tested in pleural effusions. We aimed to assess whether PTX‐3 is an accurate biomarker of parapneumonic effusions (PPE) and whether it discriminates complicated (CPPE)from non‐complicated PPE.
Methods
The concentrations of pleural fluid PTX‐3 were measured by a commercial enzyme‐linked immunosorbent assay in a prospective cohort of 84 patients with pleural effusions, including 24 PPE, 40 malignant, and 20 miscellaneous exudative effusions. The area under the curve quantified the overall diagnostic accuracy of the test. A multivariate logistic regression analysis selected pleural fluid biochemistries predictive of PPE.
Results
Median pleural fluid PTX‐3 levels were higher in PPE than in both malignant effusions and other exudates (32.4 ng/mL vs 6.7 ng/mL, and 8.5 ng/mL, respectively, P < 0.001). PTX‐3 > 12 ng/mL yielded 88% sensitivity, 73% specificity, likelihood ratio positive 3.3 and likelihood ratio negative 0.17 for diagnosing PPE, with an area under the curve of 0.855 (95% CI: 0.769–0.941). In the multivariate analysis, pleural PTX‐3 levels remained associated with increased diagnostic odds for PPE (odds ratio 17.7, 95% confidence interval: 3.7–85.1, P < 0.001). There was a non‐significant trend towards higher pleural PTX‐3 levels in CPPE as compared with non‐complicated.
Conclusions
High concentrations of PTX‐3 in pleural effusions are very sensitive to differentiate PPE from non‐PPE. However, they do not seem to differentiate uncomplicated‐complicated from CPPE differentiation.
PTX‐3 is a relatively new marker of inflammation that has not been previously tested in pleural effusions. Here, we show that PTX‐3 concentrations in pleural effusions may be helpful in distinguishing PPE from non‐PPE. Its usefulness in differentiating simple from CPPE awaits further studies.</description><identifier>ISSN: 1323-7799</identifier><identifier>EISSN: 1440-1843</identifier><identifier>DOI: 10.1111/resp.12038</identifier><identifier>PMID: 23286371</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Bacterial Infections - diagnosis ; Bacterial Infections - metabolism ; Biomarkers - metabolism ; C-reactive protein ; C-Reactive Protein - metabolism ; Cohort Studies ; diagnosis ; Diagnosis, Differential ; Female ; Humans ; Logistic Models ; Lung Diseases - diagnosis ; Lung Diseases - metabolism ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Male ; Middle Aged ; parapneumonic pleural effusion ; pentraxin-3 ; Pleural Effusion - diagnosis ; Pleural Effusion - metabolism ; Prospective Studies ; Pulmonary Embolism - diagnosis ; Pulmonary Embolism - metabolism ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Serum Amyloid P-Component - metabolism</subject><ispartof>Respirology (Carlton, Vic.), 2013-05, Vol.18 (4), p.657-662</ispartof><rights>2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology</rights><rights>2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3678-c19e2a1380bc76a4e01b13274b393007d830a0f41e34d8466d205bd3852861f63</citedby><cites>FETCH-LOGICAL-c3678-c19e2a1380bc76a4e01b13274b393007d830a0f41e34d8466d205bd3852861f63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fresp.12038$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fresp.12038$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23286371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozsu, Savas</creatorcontrib><creatorcontrib>Abul, Yasin</creatorcontrib><creatorcontrib>Mentese, Ahmet</creatorcontrib><creatorcontrib>Bektas, Hayriye</creatorcontrib><creatorcontrib>Uzun, Aysegul</creatorcontrib><creatorcontrib>Ozlu, Tevfik</creatorcontrib><creatorcontrib>Porcel, José M.</creatorcontrib><title>Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions</title><title>Respirology (Carlton, Vic.)</title><addtitle>Respirology</addtitle><description>Background and objective
Pentraxin‐3 (PTX‐3) is a relatively new marker of inflammation that has not been previously tested in pleural effusions. We aimed to assess whether PTX‐3 is an accurate biomarker of parapneumonic effusions (PPE) and whether it discriminates complicated (CPPE)from non‐complicated PPE.
Methods
The concentrations of pleural fluid PTX‐3 were measured by a commercial enzyme‐linked immunosorbent assay in a prospective cohort of 84 patients with pleural effusions, including 24 PPE, 40 malignant, and 20 miscellaneous exudative effusions. The area under the curve quantified the overall diagnostic accuracy of the test. A multivariate logistic regression analysis selected pleural fluid biochemistries predictive of PPE.
Results
Median pleural fluid PTX‐3 levels were higher in PPE than in both malignant effusions and other exudates (32.4 ng/mL vs 6.7 ng/mL, and 8.5 ng/mL, respectively, P < 0.001). PTX‐3 > 12 ng/mL yielded 88% sensitivity, 73% specificity, likelihood ratio positive 3.3 and likelihood ratio negative 0.17 for diagnosing PPE, with an area under the curve of 0.855 (95% CI: 0.769–0.941). In the multivariate analysis, pleural PTX‐3 levels remained associated with increased diagnostic odds for PPE (odds ratio 17.7, 95% confidence interval: 3.7–85.1, P < 0.001). There was a non‐significant trend towards higher pleural PTX‐3 levels in CPPE as compared with non‐complicated.
Conclusions
High concentrations of PTX‐3 in pleural effusions are very sensitive to differentiate PPE from non‐PPE. However, they do not seem to differentiate uncomplicated‐complicated from CPPE differentiation.
PTX‐3 is a relatively new marker of inflammation that has not been previously tested in pleural effusions. Here, we show that PTX‐3 concentrations in pleural effusions may be helpful in distinguishing PPE from non‐PPE. Its usefulness in differentiating simple from CPPE awaits further studies.</description><subject>Adult</subject><subject>Aged</subject><subject>Bacterial Infections - diagnosis</subject><subject>Bacterial Infections - metabolism</subject><subject>Biomarkers - metabolism</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cohort Studies</subject><subject>diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Lung Diseases - diagnosis</subject><subject>Lung Diseases - metabolism</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>parapneumonic pleural effusion</subject><subject>pentraxin-3</subject><subject>Pleural Effusion - diagnosis</subject><subject>Pleural Effusion - metabolism</subject><subject>Prospective Studies</subject><subject>Pulmonary Embolism - diagnosis</subject><subject>Pulmonary Embolism - metabolism</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Serum Amyloid P-Component - metabolism</subject><issn>1323-7799</issn><issn>1440-1843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1O3TAQRq2qqPxu-gCVlxVSwM44tm93FMEtEqKogNjVcpJJ6zaxUzuBy9vXcIEls5lZnPk0cwj5yNkBz3UYMY0HvGSg35EtLgQruBbwPs9QQqHUYrFJtlP6wxiDilUfyGYJpZag-Bb5eYl-inblfAFf6BH14Q57Wrsw2PgXI-1CpK1LTXSD83Zy_hcdbbSjx3kI3jW0i2GgYfqdWVzNbUbukGLXzckFn3bJRmf7hHvPfYfcnJ5cH38rzr8vz46PzosGpNJFwxdYWg6a1Y2SViDjdT5eiRoWwJhqNTDLOsERRKuFlG3JqroFXeU_eCdhh3xe544x_JsxTWbIR2PfW49hToaDkJUuJUBG99doE0NKETsz5udsfDCcmUef5tGnefKZ4U_PuXM9YPuKvgjMAF8D967HhzeizI-Tq8uX0GK949KEq9edLNxIBaoytxdLc8WBL6_VVyPgP-Ysjv8</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Ozsu, Savas</creator><creator>Abul, Yasin</creator><creator>Mentese, Ahmet</creator><creator>Bektas, Hayriye</creator><creator>Uzun, Aysegul</creator><creator>Ozlu, Tevfik</creator><creator>Porcel, José M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions</title><author>Ozsu, Savas ; Abul, Yasin ; Mentese, Ahmet ; Bektas, Hayriye ; Uzun, Aysegul ; Ozlu, Tevfik ; Porcel, José M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3678-c19e2a1380bc76a4e01b13274b393007d830a0f41e34d8466d205bd3852861f63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Bacterial Infections - diagnosis</topic><topic>Bacterial Infections - metabolism</topic><topic>Biomarkers - metabolism</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cohort Studies</topic><topic>diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Lung Diseases - diagnosis</topic><topic>Lung Diseases - metabolism</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>parapneumonic pleural effusion</topic><topic>pentraxin-3</topic><topic>Pleural Effusion - diagnosis</topic><topic>Pleural Effusion - metabolism</topic><topic>Prospective Studies</topic><topic>Pulmonary Embolism - diagnosis</topic><topic>Pulmonary Embolism - metabolism</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Serum Amyloid P-Component - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozsu, Savas</creatorcontrib><creatorcontrib>Abul, Yasin</creatorcontrib><creatorcontrib>Mentese, Ahmet</creatorcontrib><creatorcontrib>Bektas, Hayriye</creatorcontrib><creatorcontrib>Uzun, Aysegul</creatorcontrib><creatorcontrib>Ozlu, Tevfik</creatorcontrib><creatorcontrib>Porcel, José M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respirology (Carlton, Vic.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozsu, Savas</au><au>Abul, Yasin</au><au>Mentese, Ahmet</au><au>Bektas, Hayriye</au><au>Uzun, Aysegul</au><au>Ozlu, Tevfik</au><au>Porcel, José M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions</atitle><jtitle>Respirology (Carlton, Vic.)</jtitle><addtitle>Respirology</addtitle><date>2013-05</date><risdate>2013</risdate><volume>18</volume><issue>4</issue><spage>657</spage><epage>662</epage><pages>657-662</pages><issn>1323-7799</issn><eissn>1440-1843</eissn><abstract>Background and objective
Pentraxin‐3 (PTX‐3) is a relatively new marker of inflammation that has not been previously tested in pleural effusions. We aimed to assess whether PTX‐3 is an accurate biomarker of parapneumonic effusions (PPE) and whether it discriminates complicated (CPPE)from non‐complicated PPE.
Methods
The concentrations of pleural fluid PTX‐3 were measured by a commercial enzyme‐linked immunosorbent assay in a prospective cohort of 84 patients with pleural effusions, including 24 PPE, 40 malignant, and 20 miscellaneous exudative effusions. The area under the curve quantified the overall diagnostic accuracy of the test. A multivariate logistic regression analysis selected pleural fluid biochemistries predictive of PPE.
Results
Median pleural fluid PTX‐3 levels were higher in PPE than in both malignant effusions and other exudates (32.4 ng/mL vs 6.7 ng/mL, and 8.5 ng/mL, respectively, P < 0.001). PTX‐3 > 12 ng/mL yielded 88% sensitivity, 73% specificity, likelihood ratio positive 3.3 and likelihood ratio negative 0.17 for diagnosing PPE, with an area under the curve of 0.855 (95% CI: 0.769–0.941). In the multivariate analysis, pleural PTX‐3 levels remained associated with increased diagnostic odds for PPE (odds ratio 17.7, 95% confidence interval: 3.7–85.1, P < 0.001). There was a non‐significant trend towards higher pleural PTX‐3 levels in CPPE as compared with non‐complicated.
Conclusions
High concentrations of PTX‐3 in pleural effusions are very sensitive to differentiate PPE from non‐PPE. However, they do not seem to differentiate uncomplicated‐complicated from CPPE differentiation.
PTX‐3 is a relatively new marker of inflammation that has not been previously tested in pleural effusions. Here, we show that PTX‐3 concentrations in pleural effusions may be helpful in distinguishing PPE from non‐PPE. Its usefulness in differentiating simple from CPPE awaits further studies.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23286371</pmid><doi>10.1111/resp.12038</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1323-7799 |
| ispartof | Respirology (Carlton, Vic.), 2013-05, Vol.18 (4), p.657-662 |
| issn | 1323-7799 1440-1843 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1346582633 |
| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Aged Bacterial Infections - diagnosis Bacterial Infections - metabolism Biomarkers - metabolism C-reactive protein C-Reactive Protein - metabolism Cohort Studies diagnosis Diagnosis, Differential Female Humans Logistic Models Lung Diseases - diagnosis Lung Diseases - metabolism Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Male Middle Aged parapneumonic pleural effusion pentraxin-3 Pleural Effusion - diagnosis Pleural Effusion - metabolism Prospective Studies Pulmonary Embolism - diagnosis Pulmonary Embolism - metabolism Retrospective Studies ROC Curve Sensitivity and Specificity Serum Amyloid P-Component - metabolism |
| title | Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T22%3A55%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pentraxin-3:%20A%20novel%20biomarker%20for%20discriminating%20parapneumonic%20from%20other%20exudative%20effusions&rft.jtitle=Respirology%20(Carlton,%20Vic.)&rft.au=Ozsu,%20Savas&rft.date=2013-05&rft.volume=18&rft.issue=4&rft.spage=657&rft.epage=662&rft.pages=657-662&rft.issn=1323-7799&rft.eissn=1440-1843&rft_id=info:doi/10.1111/resp.12038&rft_dat=%3Cproquest_cross%3E1346582633%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1346582633&rft_id=info:pmid/23286371&rfr_iscdi=true |