Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study
Aim To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR). Material and Methods A prospective cohort study was...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2013-05, Vol.39 (5), p.881-890 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Ghosh, Sanjib Kumar Raheja, Shashi Tuli, Anita Raghunandan, Chitra Agarwal, Sneh |
| description | Aim
To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).
Material and Methods
A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20–22 weeks of gestation. A cut‐off value of |
| doi_str_mv | 10.1111/jog.12006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1346582266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1346582266</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4886-44a052eebcf08d09cce50c747e2390c4f2b21594829c4942e5bbc10448fbf7893</originalsourceid><addsrcrecordid>eNp1UcGO0zAQjRCIXRYO_ADyEQ7Z2o7jJCe0VFBAFXsB0ZvlOJOtl8TO2g5LP5M_YkrbFRd88YzmvTdP87LsJaOXDN_i1t9cMk6pfJSdMyGqnFalfIx1IVhe00qeZc9ivKWUVQ2rn2ZnvBCNLKg4z34vtSOjThCcHkiEMI9kGrQBl7C_Cf4-bUmvTfKBQEwWodY7Yh0BHYYdMox3HUnBjjiGQKYAnTWJpC0Qb8wcAjiDZX8keBch7VFgBj1O0WqiXbfYy_8zty4FPaOedXByEXBBQGnc_5ZcoYSPE2D7E4jxWx8SiWnuds-zJ70eIrw4_hfZtw_vvy4_5uvr1afl1To3oq5lLoSmJQdoTU_rjjbGQElNJSrgRUON6HnLWdmImjdGNIJD2baGUSHqvu2ruikustcHXTRyN6M3NdpoYBi0Az9HhceXZc25lAh9c4Aa9BwD9GrCe-mwU4yqfYIKE1R_E0Tsq6Ps3I7QPSBPkSFgcQDc2wF2_1dSn69XJ8n8wLCY0K8Hhg4_lKyKqlTfv6wUL-VmXWw26l3xBxNaus0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1346582266</pqid></control><display><type>article</type><title>Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Ghosh, Sanjib Kumar ; Raheja, Shashi ; Tuli, Anita ; Raghunandan, Chitra ; Agarwal, Sneh</creator><creatorcontrib>Ghosh, Sanjib Kumar ; Raheja, Shashi ; Tuli, Anita ; Raghunandan, Chitra ; Agarwal, Sneh</creatorcontrib><description>Aim
To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).
Material and Methods
A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20–22 weeks of gestation. A cut‐off value of <155 pg/mL for serum PlGF was determined by receiver operating characteristic (ROC) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and/or early onset IUGR. Preeclampsia and IUGR were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR) and odds ratio (OR) was computed. P‐value < 0.05 was considered statistically significant.
Results
Maternal serum PlGF level <155 pg/mL at 20–22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95% CI 1.79–18.94; P = 0.007) and with early onset IUGR (OR 10.73; 95% CI 4.08–20.23; P = 0.000). The sensitivity of serum PlGF < 155 pg/mL for predicting early onset preeclampsia and early onset IUGR were 82 and 84, respectively.
Conclusion
Maternal serum PlGF level estimation in early second trimester (20–22 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and/or early onset IUGR.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/jog.12006</identifier><identifier>PMID: 23496304</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adult ; Cohort Studies ; Early Diagnosis ; early onset intrauterine growth restriction ; early onset preeclampsia ; early second trimester ; Female ; Fetal Growth Retardation - blood ; Fetal Growth Retardation - diagnosis ; Humans ; logistic regression analysis ; Placenta Growth Factor ; Pre-Eclampsia - blood ; Pre-Eclampsia - diagnosis ; Pregnancy ; Pregnancy Proteins - blood ; Pregnancy Trimester, Second ; Prospective Studies ; Sensitivity and Specificity ; serum placental growth factor ; Young Adult</subject><ispartof>The journal of obstetrics and gynaecology research, 2013-05, Vol.39 (5), p.881-890</ispartof><rights>2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology</rights><rights>2013 The Authors. Journal of Obstetrics and Gynaecology Research © 2013 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4886-44a052eebcf08d09cce50c747e2390c4f2b21594829c4942e5bbc10448fbf7893</citedby><cites>FETCH-LOGICAL-c4886-44a052eebcf08d09cce50c747e2390c4f2b21594829c4942e5bbc10448fbf7893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjog.12006$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjog.12006$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23496304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghosh, Sanjib Kumar</creatorcontrib><creatorcontrib>Raheja, Shashi</creatorcontrib><creatorcontrib>Tuli, Anita</creatorcontrib><creatorcontrib>Raghunandan, Chitra</creatorcontrib><creatorcontrib>Agarwal, Sneh</creatorcontrib><title>Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aim
To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).
Material and Methods
A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20–22 weeks of gestation. A cut‐off value of <155 pg/mL for serum PlGF was determined by receiver operating characteristic (ROC) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and/or early onset IUGR. Preeclampsia and IUGR were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR) and odds ratio (OR) was computed. P‐value < 0.05 was considered statistically significant.
Results
Maternal serum PlGF level <155 pg/mL at 20–22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95% CI 1.79–18.94; P = 0.007) and with early onset IUGR (OR 10.73; 95% CI 4.08–20.23; P = 0.000). The sensitivity of serum PlGF < 155 pg/mL for predicting early onset preeclampsia and early onset IUGR were 82 and 84, respectively.
Conclusion
Maternal serum PlGF level estimation in early second trimester (20–22 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and/or early onset IUGR.</description><subject>Adult</subject><subject>Cohort Studies</subject><subject>Early Diagnosis</subject><subject>early onset intrauterine growth restriction</subject><subject>early onset preeclampsia</subject><subject>early second trimester</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetal Growth Retardation - diagnosis</subject><subject>Humans</subject><subject>logistic regression analysis</subject><subject>Placenta Growth Factor</subject><subject>Pre-Eclampsia - blood</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Pregnancy</subject><subject>Pregnancy Proteins - blood</subject><subject>Pregnancy Trimester, Second</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>serum placental growth factor</subject><subject>Young Adult</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UcGO0zAQjRCIXRYO_ADyEQ7Z2o7jJCe0VFBAFXsB0ZvlOJOtl8TO2g5LP5M_YkrbFRd88YzmvTdP87LsJaOXDN_i1t9cMk6pfJSdMyGqnFalfIx1IVhe00qeZc9ivKWUVQ2rn2ZnvBCNLKg4z34vtSOjThCcHkiEMI9kGrQBl7C_Cf4-bUmvTfKBQEwWodY7Yh0BHYYdMox3HUnBjjiGQKYAnTWJpC0Qb8wcAjiDZX8keBch7VFgBj1O0WqiXbfYy_8zty4FPaOedXByEXBBQGnc_5ZcoYSPE2D7E4jxWx8SiWnuds-zJ70eIrw4_hfZtw_vvy4_5uvr1afl1To3oq5lLoSmJQdoTU_rjjbGQElNJSrgRUON6HnLWdmImjdGNIJD2baGUSHqvu2ruikustcHXTRyN6M3NdpoYBi0Az9HhceXZc25lAh9c4Aa9BwD9GrCe-mwU4yqfYIKE1R_E0Tsq6Ps3I7QPSBPkSFgcQDc2wF2_1dSn69XJ8n8wLCY0K8Hhg4_lKyKqlTfv6wUL-VmXWw26l3xBxNaus0</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Ghosh, Sanjib Kumar</creator><creator>Raheja, Shashi</creator><creator>Tuli, Anita</creator><creator>Raghunandan, Chitra</creator><creator>Agarwal, Sneh</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study</title><author>Ghosh, Sanjib Kumar ; Raheja, Shashi ; Tuli, Anita ; Raghunandan, Chitra ; Agarwal, Sneh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4886-44a052eebcf08d09cce50c747e2390c4f2b21594829c4942e5bbc10448fbf7893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Cohort Studies</topic><topic>Early Diagnosis</topic><topic>early onset intrauterine growth restriction</topic><topic>early onset preeclampsia</topic><topic>early second trimester</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Fetal Growth Retardation - diagnosis</topic><topic>Humans</topic><topic>logistic regression analysis</topic><topic>Placenta Growth Factor</topic><topic>Pre-Eclampsia - blood</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Pregnancy</topic><topic>Pregnancy Proteins - blood</topic><topic>Pregnancy Trimester, Second</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>serum placental growth factor</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghosh, Sanjib Kumar</creatorcontrib><creatorcontrib>Raheja, Shashi</creatorcontrib><creatorcontrib>Tuli, Anita</creatorcontrib><creatorcontrib>Raghunandan, Chitra</creatorcontrib><creatorcontrib>Agarwal, Sneh</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghosh, Sanjib Kumar</au><au>Raheja, Shashi</au><au>Tuli, Anita</au><au>Raghunandan, Chitra</au><au>Agarwal, Sneh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2013-05</date><risdate>2013</risdate><volume>39</volume><issue>5</issue><spage>881</spage><epage>890</epage><pages>881-890</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aim
To determine whether maternal serum placental growth factor (PlGF) estimation in early second trimester (20–22 weeks of gestation) can predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction (IUGR).
Material and Methods
A prospective cohort study was conducted on 722 women with singleton pregnancies, screened from the antenatal clinic, and serum PlGF levels were estimated at 20–22 weeks of gestation. A cut‐off value of <155 pg/mL for serum PlGF was determined by receiver operating characteristic (ROC) curve analysis for identifying pregnant women at risk of developing early onset preeclampsia and/or early onset IUGR. Preeclampsia and IUGR were classified as early onset when diagnosed by 32 weeks of gestation. Univariate logistic regression analysis was used to analyze the association between serum PlGF level <155 pg/mL and the two outcome measures (i.e. early onset preeclampsia and early onset IUGR) and odds ratio (OR) was computed. P‐value < 0.05 was considered statistically significant.
Results
Maternal serum PlGF level <155 pg/mL at 20–22 weeks of gestation had a strong association with early onset preeclampsia (OR 8.35; 95% CI 1.79–18.94; P = 0.007) and with early onset IUGR (OR 10.73; 95% CI 4.08–20.23; P = 0.000). The sensitivity of serum PlGF < 155 pg/mL for predicting early onset preeclampsia and early onset IUGR were 82 and 84, respectively.
Conclusion
Maternal serum PlGF level estimation in early second trimester (20–22 weeks of gestation) may be useful in predicting the occurrence of early onset preeclampsia and/or early onset IUGR.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23496304</pmid><doi>10.1111/jog.12006</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The journal of obstetrics and gynaecology research, 2013-05, Vol.39 (5), p.881-890 |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adult Cohort Studies Early Diagnosis early onset intrauterine growth restriction early onset preeclampsia early second trimester Female Fetal Growth Retardation - blood Fetal Growth Retardation - diagnosis Humans logistic regression analysis Placenta Growth Factor Pre-Eclampsia - blood Pre-Eclampsia - diagnosis Pregnancy Pregnancy Proteins - blood Pregnancy Trimester, Second Prospective Studies Sensitivity and Specificity serum placental growth factor Young Adult |
| title | Can maternal serum placental growth factor estimation in early second trimester predict the occurrence of early onset preeclampsia and/or early onset intrauterine growth restriction? A prospective cohort study |
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