PEGylated starch acetate nanoparticles and its potential use for oral insulin delivery

► Hydrophilic polyethylene glycol was conjugated with hydrophobic starch acetate. ► Nanoparticles were formed by self aggregation of this polymer conjugate. ► These nanoparticles were highly bioadhesive compared to chitosan. ► These nanoparticles can incorporate insulin and release it in a sustained...

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Veröffentlicht in:	Carbohydrate polymers 2013-06, Vol.95 (1), p.1-8
Hauptverfasser:	Minimol, P.F., Paul, Willi, Sharma, Chandra P.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetates Actins - metabolism Adhesiveness Administration, Oral Animals Applied sciences biocompatibility biodegradability Biological and medical sciences Caco-2 Cells Cell Line Cell Survival - drug effects Drug Carriers - chemistry Drug Carriers - pharmacology drugs encapsulation Exact sciences and technology Gastric Juice - chemistry General pharmacology Humans hydrophobicity insulin Insulin - administration & dosage Insulin - chemistry Insulin delivery Intestinal Secretions - chemistry Medical sciences Mice micelles molecular weight nanoparticles Nanoparticles - chemistry Natural polymers particle size PEG conjugation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology proteins Self-aggregation starch Starch - analogs & derivatives Starch - chemistry Starch - pharmacology Starch acetate Starch and polysaccharides Zonula Occludens-1 Protein - metabolism
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