Occludin is required for TRPV1-modulated paracellular permeability in the submandibular gland

Occludin plays an important role in maintaining tight junction barrier function in many types of epithelia. We previously reported that activation of transient receptor potential vanilloid subtype 1 (TRPV1) in rabbit submandibular gland promoted salivary secretion, partly by an increase in paracellu...

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Veröffentlicht in:	Journal of cell science 2013-03, Vol.126 (Pt 5), p.1109-1121
Hauptverfasser:	Cong, Xin, Zhang, Yan, Yang, Ning-Yan, Li, Jing, Ding, Chong, Ding, Qian-Wen, Su, Yun-Chao, Mei, Mei, Guo, Xiao-Hong, Wu, Li-Ling, Yu, Guang-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Capsaicin - analogs & derivatives Capsaicin - pharmacology Cell Line Flavonoids - pharmacology Immunoprecipitation Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Occludin - metabolism Phosphorylation - drug effects Rats Reverse Transcriptase Polymerase Chain Reaction Submandibular Gland - metabolism Tight Junctions - drug effects Tight Junctions - metabolism TRPV Cation Channels - antagonists & inhibitors TRPV Cation Channels - metabolism
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