Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1
Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer...
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Veröffentlicht in: | Chirurgia (Bucharest, Romania : 1990) Romania : 1990), 2013-03, Vol.108 (2), p.259-263 |
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description | Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling. |
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Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling.</description><identifier>ISSN: 1221-9118</identifier><identifier>PMID: 23618579</identifier><language>eng</language><publisher>Romania</publisher><subject>Biomarkers - analysis ; BRCA1 Protein - analysis ; Breast Neoplasms - chemistry ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Carcinoma - chemistry ; Carcinoma - pathology ; Carcinoma - surgery ; Dysgerminoma - chemistry ; Dysgerminoma - pathology ; Dysgerminoma - surgery ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Humans ; Hysterectomy ; Immunohistochemistry ; Mastectomy, Modified Radical ; Middle Aged ; Neoplasm Staging ; Neoplasms, Multiple Primary - chemistry ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - surgery ; Ovarian Neoplasms - chemistry ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Ovariectomy ; Salpingectomy ; Treatment Outcome ; Tumor Suppressor Protein p53 - analysis</subject><ispartof>Chirurgia (Bucharest, Romania : 1990), 2013-03, Vol.108 (2), p.259-263</ispartof><rights>Celsius.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23618579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Băltătescu, G I</creatorcontrib><creatorcontrib>Așchie, M</creatorcontrib><creatorcontrib>Sârbu, V</creatorcontrib><title>Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1</title><title>Chirurgia (Bucharest, Romania : 1990)</title><addtitle>Chirurgia (Bucur)</addtitle><description>Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling.</description><subject>Biomarkers - analysis</subject><subject>BRCA1 Protein - analysis</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Carcinoma - chemistry</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Dysgerminoma - chemistry</subject><subject>Dysgerminoma - pathology</subject><subject>Dysgerminoma - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Immunohistochemistry</subject><subject>Mastectomy, Modified Radical</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Multiple Primary - chemistry</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - surgery</subject><subject>Ovarian Neoplasms - chemistry</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Ovariectomy</subject><subject>Salpingectomy</subject><subject>Treatment Outcome</subject><subject>Tumor Suppressor Protein p53 - analysis</subject><issn>1221-9118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtqwzAURLVoaUKaXyhadmPwlS3JWqahLwgU-liba_umUYklV5JT8vc1JJnNwHAYmLlicxACMgNQzdgyxp98kspFnhc3bCYKBZXUZs7o4-jaXfDOj5H7AwaLjnfH-E2ht873yNF1vAmEMfEWQ3sKrePIB0yWXOJ_Nu344KNN9kDc9v3ofEw4MX7LH97XK7hl11vcR1qefcG-nh4_1y_Z5u35db3aZIMASFkrlUFFmBuBnaBCNp3UGlGUWkFZVpp0kVNXNQZMbqTAstmCMaBASEKAYsHuT71D8L8jxVT3Nra036OjaWANRamkroQ2E3p3Rsemp64egu0xHOvLNcU_H2lfuQ</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Băltătescu, G I</creator><creator>Așchie, M</creator><creator>Sârbu, V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1</title><author>Băltătescu, G I ; Așchie, M ; Sârbu, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-c569a6ea092ad2e35bd577aa247614487e730ed8b9190952a4bf19916125ea113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomarkers - analysis</topic><topic>BRCA1 Protein - analysis</topic><topic>Breast Neoplasms - chemistry</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Carcinoma - chemistry</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Dysgerminoma - chemistry</topic><topic>Dysgerminoma - pathology</topic><topic>Dysgerminoma - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Immunohistochemistry</topic><topic>Mastectomy, Modified Radical</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Multiple Primary - chemistry</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - surgery</topic><topic>Ovarian Neoplasms - chemistry</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Ovariectomy</topic><topic>Salpingectomy</topic><topic>Treatment Outcome</topic><topic>Tumor Suppressor Protein p53 - analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Băltătescu, G I</creatorcontrib><creatorcontrib>Așchie, M</creatorcontrib><creatorcontrib>Sârbu, V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Băltătescu, G I</au><au>Așchie, M</au><au>Sârbu, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1</atitle><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle><addtitle>Chirurgia (Bucur)</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>108</volume><issue>2</issue><spage>259</spage><epage>263</epage><pages>259-263</pages><issn>1221-9118</issn><abstract>Breast cancer is the most common malignant neoplastic process and the second cause of death for women. Ovarian cancer, despite having a lower incidence, represents an important cause of morbidity and mortality because it is usually discovered in advanced stages. The presence of both forms of cancer in a patient is associated with a high risk of BRCA1 gene mutations, which are responsible, together with BRCA2 gene mutations, for most of the breast and ovarian cancer family. Our case is special because it presents a synchronous and a rare association of a primary ovarian dysgerminoma (with an incidence of less than 1% of ovarian cancers) and a primary breast carcinoma in a patient of 46 years old. Immunohistochemical examination was performed using a panel of five biomarkers: oestrogen receptor, progesterone receptor, Herceptest, p53 and BRCA1. In our case, we identified a negative hormonal status and the absence of HER2/neu expression but a positive immuno-expression for p53 protein and BRCA1 protein. Postoperative course was favourable for the patient after each surgery, and she was discharged with the recommendation to perform a genetic counselling.</abstract><cop>Romania</cop><pmid>23618579</pmid><tpages>5</tpages></addata></record> |
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subjects | Biomarkers - analysis BRCA1 Protein - analysis Breast Neoplasms - chemistry Breast Neoplasms - pathology Breast Neoplasms - surgery Carcinoma - chemistry Carcinoma - pathology Carcinoma - surgery Dysgerminoma - chemistry Dysgerminoma - pathology Dysgerminoma - surgery Female Follow-Up Studies Genetic Predisposition to Disease Humans Hysterectomy Immunohistochemistry Mastectomy, Modified Radical Middle Aged Neoplasm Staging Neoplasms, Multiple Primary - chemistry Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - surgery Ovarian Neoplasms - chemistry Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Ovariectomy Salpingectomy Treatment Outcome Tumor Suppressor Protein p53 - analysis |
title | Synchronous ovarian dysgerminoma and breast carcinoma in a patient with positive immunostain of BRCA1 |
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