Polyhydroxylated pyrrolizidine alkaloids from transannular iodoaminations: application to the asymmetric syntheses of (-)-hyacinthacine A1, (-)-7a-epi-hyacinthacine A1, (-)-hyacinthacine A2, and (-)-1-epi-alexine

The transannular iodoamination of substituted 1,2,3,4,7,8-hexahydroazocine scaffolds has been developed into a versatile, diastereodivergent route to enable the synthesis of a range of pyrrolizidine alkaloids, as demonstrated by the syntheses of (-)-hyacinthacine A1, (-)-7a-epi-hyacinthacine A1, (-)...

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Veröffentlicht in:	Organic & biomolecular chemistry 2013-01, Vol.11 (19), p.3187-3202
Hauptverfasser:	Brock, E Anne, Davies, Stephen G, Lee, James A, Roberts, Paul M, Thomson, James E
Format:	Artikel
Sprache:	eng
Schlagworte:	Amination Crystallography, X-Ray Models, Molecular Molecular Conformation Pyrrolizidine Alkaloids - chemical synthesis Pyrrolizidine Alkaloids - chemistry
Online-Zugang:	Volltext
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