Interleukin‐17A+ Cell Counts Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated With the Extent of Skin Involvement

Objective Levels of interleukin‐17A (IL‐17A) have been found to be increased in synovial fluid from individuals with systemic sclerosis (SSc). This study was undertaken to investigate whether IL‐17A–producing cells are present in affected SSc skin, and whether IL‐17A exerts a role in the transdiffer...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2013-05, Vol.65 (5), p.1347-1356
Hauptverfasser:	Truchetet, Marie‐Elise, Brembilla, Nicolò‐Costantino, Montanari, Elisa, Lonati, Paola, Raschi, Elena, Zeni, Silvana, Fontao, Lionel, Meroni, Pier‐Luigi, Chizzolini, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Adult Aged Biomarkers - metabolism Cell Count Cell Transdifferentiation Cells Cytokines Dermis - immunology Dermis - metabolism Dermis - pathology Female Humans Immunity, Innate - immunology Interleukin-17 - immunology Interleukin-17 - metabolism Male Middle Aged Myofibroblasts - metabolism Myofibroblasts - pathology Proteins Scleroderma, Systemic - immunology Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Wound healing
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