Obesity Is Not Associated With Aggressive Pathologic Features or Biochemical Recurrence After Radical Prostatectomy

Objective To determine whether obesity is associated with adverse pathologic characteristics, positive surgical margins, greater biochemical recurrence rates, and interval to death after primary treatment with radical prostatectomy (RP). Materials and Methods A 12-year, retrospective, single-institution analysis of patients treated with RP was performed. Patients were categorized by their body mass index (BMI) as normal weight (n = 533), overweight (n = 1342), obese (n = 603), and morbidly obese (n = 22). The associations among the BMI, clinicopathologic characteristics, and biochemical recurrence rates were assessed. Results After adjusting for multiple clinical preoperative characteristics, the BMI category was not associated with positive surgical margins ( P = .66), organ-confined disease ( P = .10), Gleason score ( P = .22), extracapsular extension ( P = .09), seminal vesicle invasion ( P = .15), percentage of cancer in the prostate gland ( P = .67), largest tumor nodule ( P = .13), or lymph node metastasis ( P = .39). Gleason score 4+3 ( P