Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model
The aim of this study is to analyze the histological composition of acute arterial thrombi and their MRI signals. Two different types of experimental thrombi, erythrocyte- and fibrin-rich thrombus, were created and injected into an experimentally formed stenotic common carotid artery in swine. MRI o...
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| Veröffentlicht in: | Stroke (1970) 2013-05, Vol.44 (5), p.1463-1465 |
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| container_title | Stroke (1970) |
| container_volume | 44 |
| creator | FUJIMOTO, Motoaki SALAMON, Noriko MAYOR, Fernando YUKI, Ichiro TAKEMOTO, Koichiro VINTERS, Harry V VINUELA, Fernando |
| description | The aim of this study is to analyze the histological composition of acute arterial thrombi and their MRI signals.
Two different types of experimental thrombi, erythrocyte- and fibrin-rich thrombus, were created and injected into an experimentally formed stenotic common carotid artery in swine. MRI of the in vivo and in vitro samples was obtained immediately after the thrombus application.
Erythrocyte component showed high on fluid-attenuated inversion recovery, and iso on T2-weighted signal in both in vitro and in vivo. Fibrin-rich thrombus was composed of fibrin/platelet and nucleated cell layers, which demonstrated iso- and low intensities, respectively, in both fluid-attenuated inversion recovery and T2-weighted images in vitro. Mixed signal was obtained in vivo.
We successfully characterized the only erythrocyte component of acute thrombus by MRI. |
| doi_str_mv | 10.1161/STROKEAHA.111.000457 |
| format | Article |
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Two different types of experimental thrombi, erythrocyte- and fibrin-rich thrombus, were created and injected into an experimentally formed stenotic common carotid artery in swine. MRI of the in vivo and in vitro samples was obtained immediately after the thrombus application.
Erythrocyte component showed high on fluid-attenuated inversion recovery, and iso on T2-weighted signal in both in vitro and in vivo. Fibrin-rich thrombus was composed of fibrin/platelet and nucleated cell layers, which demonstrated iso- and low intensities, respectively, in both fluid-attenuated inversion recovery and T2-weighted images in vitro. Mixed signal was obtained in vivo.
We successfully characterized the only erythrocyte component of acute thrombus by MRI.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/STROKEAHA.111.000457</identifier><identifier>PMID: 23493736</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Animals ; Biological and medical sciences ; Blood Platelets - pathology ; Carotid Artery, Common - pathology ; Carotid Stenosis - pathology ; Disease Models, Animal ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Imaging ; Medical sciences ; Nervous system ; Neurology ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Stroke - pathology ; Swine ; Thrombosis - pathology ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2013-05, Vol.44 (5), p.1463-1465</ispartof><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-a82b4134accccad8e9835e7289fa938609430364161bc25f4cdb024eab04ee1d3</citedby><cites>FETCH-LOGICAL-c383t-a82b4134accccad8e9835e7289fa938609430364161bc25f4cdb024eab04ee1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27321638$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23493736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FUJIMOTO, Motoaki</creatorcontrib><creatorcontrib>SALAMON, Noriko</creatorcontrib><creatorcontrib>MAYOR, Fernando</creatorcontrib><creatorcontrib>YUKI, Ichiro</creatorcontrib><creatorcontrib>TAKEMOTO, Koichiro</creatorcontrib><creatorcontrib>VINTERS, Harry V</creatorcontrib><creatorcontrib>VINUELA, Fernando</creatorcontrib><title>Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>The aim of this study is to analyze the histological composition of acute arterial thrombi and their MRI signals.
Two different types of experimental thrombi, erythrocyte- and fibrin-rich thrombus, were created and injected into an experimentally formed stenotic common carotid artery in swine. MRI of the in vivo and in vitro samples was obtained immediately after the thrombus application.
Erythrocyte component showed high on fluid-attenuated inversion recovery, and iso on T2-weighted signal in both in vitro and in vivo. Fibrin-rich thrombus was composed of fibrin/platelet and nucleated cell layers, which demonstrated iso- and low intensities, respectively, in both fluid-attenuated inversion recovery and T2-weighted images in vitro. Mixed signal was obtained in vivo.
We successfully characterized the only erythrocyte component of acute thrombus by MRI.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - pathology</subject><subject>Carotid Artery, Common - pathology</subject><subject>Carotid Stenosis - pathology</subject><subject>Disease Models, Animal</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Stroke - pathology</subject><subject>Swine</subject><subject>Thrombosis - pathology</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkNtKw0AQhhdRbD28gcjeCN5E95TTZSn1gBXB1usw2Uza1SRbd1NEn97V1jo3ww_fzDAfIWecXXGe8OvZ_PnpYTK6G4XIrxhjKk73yJDHQkUqEdk-GTIm80ioPB-QI-9fAyNkFh-SgZAql6lMhmQxXoID3aMzX9Ab21Fb05H7ydDQ-dLZtlx7OrbtynrzC5Sf9BEWHfZG02f0toNOI71vYWG6BTUdBTr7MB3SWe_sG9JHW2FzQg5qaDyebvsxebmZzMd30fTp9n48mkZaZrKPIBOl4lKBDgVVhnkmY0xFlteQyyxhuZJMJioIKLWIa6WrkgmFUDKFyCt5TC43e1fOvq_R90VrvMamgQ7t2hdhdxzzNI2TgKoNqp313mFdrJxpwX0WnBU_ioud4hB5sVEcxs63F9Zli9Vu6M9pAC62AHgNTe2CH-P_uVQKnoRvvwFqj4V-</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>FUJIMOTO, Motoaki</creator><creator>SALAMON, Noriko</creator><creator>MAYOR, Fernando</creator><creator>YUKI, Ichiro</creator><creator>TAKEMOTO, Koichiro</creator><creator>VINTERS, Harry V</creator><creator>VINUELA, Fernando</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model</title><author>FUJIMOTO, Motoaki ; SALAMON, Noriko ; MAYOR, Fernando ; YUKI, Ichiro ; TAKEMOTO, Koichiro ; VINTERS, Harry V ; VINUELA, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-a82b4134accccad8e9835e7289fa938609430364161bc25f4cdb024eab04ee1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - pathology</topic><topic>Carotid Artery, Common - pathology</topic><topic>Carotid Stenosis - pathology</topic><topic>Disease Models, Animal</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Stroke - pathology</topic><topic>Swine</topic><topic>Thrombosis - pathology</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FUJIMOTO, Motoaki</creatorcontrib><creatorcontrib>SALAMON, Noriko</creatorcontrib><creatorcontrib>MAYOR, Fernando</creatorcontrib><creatorcontrib>YUKI, Ichiro</creatorcontrib><creatorcontrib>TAKEMOTO, Koichiro</creatorcontrib><creatorcontrib>VINTERS, Harry V</creatorcontrib><creatorcontrib>VINUELA, Fernando</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FUJIMOTO, Motoaki</au><au>SALAMON, Noriko</au><au>MAYOR, Fernando</au><au>YUKI, Ichiro</au><au>TAKEMOTO, Koichiro</au><au>VINTERS, Harry V</au><au>VINUELA, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>44</volume><issue>5</issue><spage>1463</spage><epage>1465</epage><pages>1463-1465</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>The aim of this study is to analyze the histological composition of acute arterial thrombi and their MRI signals.
Two different types of experimental thrombi, erythrocyte- and fibrin-rich thrombus, were created and injected into an experimentally formed stenotic common carotid artery in swine. MRI of the in vivo and in vitro samples was obtained immediately after the thrombus application.
Erythrocyte component showed high on fluid-attenuated inversion recovery, and iso on T2-weighted signal in both in vitro and in vivo. Fibrin-rich thrombus was composed of fibrin/platelet and nucleated cell layers, which demonstrated iso- and low intensities, respectively, in both fluid-attenuated inversion recovery and T2-weighted images in vitro. Mixed signal was obtained in vivo.
We successfully characterized the only erythrocyte component of acute thrombus by MRI.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>23493736</pmid><doi>10.1161/STROKEAHA.111.000457</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Stroke (1970), 2013-05, Vol.44 (5), p.1463-1465 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; American Heart Association Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Blood Platelets - pathology Carotid Artery, Common - pathology Carotid Stenosis - pathology Disease Models, Animal Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Medical sciences Nervous system Neurology Radiodiagnosis. Nmr imagery. Nmr spectrometry Stroke - pathology Swine Thrombosis - pathology Vascular diseases and vascular malformations of the nervous system |
| title | Characterization of Arterial Thrombus Composition by Magnetic Resonance Imaging in a Swine Stroke Model |
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