Non-steroidal anti-inflammatory drug for pulmonary administration: Design and investigation of ketoprofen lysinate fine dry powders

Pulmonary inflammation is an important therapeutic target in cystic fibrosis (CF) patients, aiming to limit and delay the lung damage. The purpose of the present research was to produce respirable engineered particles of ketoprofen lysinate, a non-steroidal anti-inflammatory drug able to fight lung...

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Veröffentlicht in:	International journal of pharmaceutics 2013-05, Vol.448 (1), p.198-204
Hauptverfasser:	Stigliani, Mariateresa, Aquino, Rita P., Del Gaudio, Pasquale, Mencherini, Teresa, Sansone, Francesca, Russo, Paola
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - chemistry Calorimetry, Differential Scanning Cell Line Cell Proliferation - drug effects CF artificial mucus Cystic Fibrosis Drug Compounding - methods Drug Design Dry powder inhaler Dry Powder Inhalers Humans Ketoprofen - administration & dosage Ketoprofen - analogs & derivatives Ketoprofen - chemistry Ketoprofen lysine salt l-Leucine Leucine - chemistry Lysine - administration & dosage Lysine - analogs & derivatives Lysine - chemistry Microscopy, Electron, Scanning Mucus NSAIDs Particle Size Powders
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