The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage
Abstract We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)–producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We i...
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| Veröffentlicht in: | Diagnostic microbiology and infectious disease 2013-05, Vol.76 (1), p.80-85 |
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| container_title | Diagnostic microbiology and infectious disease |
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| creator | Picão, Renata C Cardoso, Juliana P Campana, Eloiza H Nicoletti, Adriana G Petrolini, Fernanda V.B Assis, Diego M Juliano, Luiz Gales, Ana C |
| description | Abstract We investigated the antimicrobial resistance profile and the occurrence of Klebsiella pneumoniae carbapenemase (KPC)–producing Gram-negative rods in sewage samples obtained from a Brazilian teaching hospital and from the wastewater treatment plant (WWTP) that receives it for treatment. We identified multidrug-resistant bacteria as well as KPC-2–producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the blaKPC-2 gene harbored on a transposon that was carried by conjugative plasmids. The presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals. |
| doi_str_mv | 10.1016/j.diagmicrobio.2013.02.001 |
| format | Article |
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We identified multidrug-resistant bacteria as well as KPC-2–producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the blaKPC-2 gene harbored on a transposon that was carried by conjugative plasmids. The presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals.</description><identifier>ISSN: 0732-8893</identifier><identifier>EISSN: 1879-0070</identifier><identifier>DOI: 10.1016/j.diagmicrobio.2013.02.001</identifier><identifier>PMID: 23478032</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acinetobacter - drug effects ; Acinetobacter - isolation & purification ; Aeromonas - drug effects ; Aeromonas - isolation & purification ; Bacterial Proteins - genetics ; beta-Lactamases - genetics ; blaKPC dissemination ; Brazil ; Carbapenemases ; DNA Transposable Elements ; Drug Resistance, Multiple, Bacterial ; Enterobacteriaceae - drug effects ; Enterobacteriaceae - isolation & purification ; Hospitals, Teaching ; Infectious Disease ; Internal Medicine ; Kluyvera - drug effects ; Kluyvera - isolation & purification ; Microbial Sensitivity Tests ; Plasmids - genetics ; Pseudomonas - drug effects ; Pseudomonas - isolation & purification ; Sewage - microbiology ; Wastewater</subject><ispartof>Diagnostic microbiology and infectious disease, 2013-05, Vol.76 (1), p.80-85</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. 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We identified multidrug-resistant bacteria as well as KPC-2–producing Aeromonas spp. and several Enterobacteriaceae species, including Kluyvera spp., in the hospital effluent and in different sites of the WWTP. Most isolates showed the blaKPC-2 gene harbored on a transposon that was carried by conjugative plasmids. The presence of KPC production among Aeromonas spp., Kluyvera spp., and other Enterobacteriaceae indicates the adaptability of such isolates to aquatic environments, not only in the hospital effluent but also throughout the WWTP. Although secondary treatment seems to decrease the amount of KPC producers in sewage, multidrug-resistant isolates are continually disposed in the urban river. Thus, sewage treatment regulations are urgently needed to decelerate the evolution of antimicrobial resistance beyond hospitals.</description><subject>Acinetobacter - drug effects</subject><subject>Acinetobacter - isolation & purification</subject><subject>Aeromonas - drug effects</subject><subject>Aeromonas - isolation & purification</subject><subject>Bacterial Proteins - genetics</subject><subject>beta-Lactamases - genetics</subject><subject>blaKPC dissemination</subject><subject>Brazil</subject><subject>Carbapenemases</subject><subject>DNA Transposable Elements</subject><subject>Drug Resistance, Multiple, Bacterial</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Hospitals, Teaching</subject><subject>Infectious Disease</subject><subject>Internal Medicine</subject><subject>Kluyvera - drug effects</subject><subject>Kluyvera - isolation & purification</subject><subject>Microbial Sensitivity Tests</subject><subject>Plasmids - genetics</subject><subject>Pseudomonas - drug effects</subject><subject>Pseudomonas - isolation & purification</subject><subject>Sewage - microbiology</subject><subject>Wastewater</subject><issn>0732-8893</issn><issn>1879-0070</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUk1v1DAQjRCIbgt_AVmcuCSM43w4PSBVSymISiBRzpZjT7ZeEjvYTlF_FP8Rp7sgxInTSDNv3rPfmyx7SaGgQJvX-0IbuZuM8q43riiBsgLKAoA-yjaUt10O0MLjbAMtK3POO3aSnYawT4Cyq-BpdlKyquXAyk328-YWiXdLROIGIm00R145Eo_BhCitQjJ4N5GYoLcuzCamIQ7DuKCNJLqHAdo7452dUuucDE4tgTj7MHFKLd7jSpMkPn7e5rN3elHG7sgFJmJnZSBhnoukr8mljanZS5WKkQolEmNJwB9yh8-yJ4McAz4_1rPs67vLm-37_PrT1YftxXWu6prFXHZKlXrooGpg0F2rZddTzXpVt5xV2FSMNxprxqXmFHTDuZYJyErsK8olsrPs1YE3vfT7giGKyQSF4ygtuiUIyqq6pmXdQoKeH6DJtRA8DmL2ZpL-XlAQa1xiL_6OS6xxCShFSiMtvzjqLP2E-s_q73wS4O0BgOm3dwa9CMqsVmrjUUWhnfk_nTf_0KjRWKPk-A3vMezd4m3yU1AR0oL4sh7OejeUAUADDfsFLXjGTg</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Picão, Renata C</creator><creator>Cardoso, Juliana P</creator><creator>Campana, Eloiza H</creator><creator>Nicoletti, Adriana G</creator><creator>Petrolini, Fernanda V.B</creator><creator>Assis, Diego M</creator><creator>Juliano, Luiz</creator><creator>Gales, Ana C</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage</title><author>Picão, Renata C ; 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| subjects | Acinetobacter - drug effects Acinetobacter - isolation & purification Aeromonas - drug effects Aeromonas - isolation & purification Bacterial Proteins - genetics beta-Lactamases - genetics blaKPC dissemination Brazil Carbapenemases DNA Transposable Elements Drug Resistance, Multiple, Bacterial Enterobacteriaceae - drug effects Enterobacteriaceae - isolation & purification Hospitals, Teaching Infectious Disease Internal Medicine Kluyvera - drug effects Kluyvera - isolation & purification Microbial Sensitivity Tests Plasmids - genetics Pseudomonas - drug effects Pseudomonas - isolation & purification Sewage - microbiology Wastewater |
| title | The route of antimicrobial resistance from the hospital effluent to the environment: focus on the occurrence of KPC-producing Aeromonas spp. and Enterobacteriaceae in sewage |
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