Preservation of Motor Function After Spinal Cord Ischemia and Reperfusion Injury Through Microglial Inhibition

Background Paraplegia remains a devastating complication of thoracoabdominal aortic procedures resulting from spinal cord ischemia and reperfusion injury (SCIR). Pharmacologic interventions have not proven efficacious in attenuating this injury, with poor understanding of the underlying mechanisms....

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Veröffentlicht in:	The Annals of thoracic surgery 2013-05, Vol.95 (5), p.1647-1653
Hauptverfasser:	Smith, Phillip D., MD, Bell, Marshall T., MD, Puskas, Ferenc, MD, PhD, Meng, Xianzhong, MD, PhD, Cleveland, Joseph C., MD, Weyant, Michael J., MD, Fullerton, David A., MD, Reece, T. Brett, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiothoracic Surgery Inflammation - etiology Male Mice Mice, Inbred C57BL Microglia - physiology Minocycline - pharmacology Motor Activity Nerve Degeneration - etiology Reperfusion Injury - physiopathology Spinal Cord Ischemia - physiopathology Surgery Tumor Necrosis Factor-alpha - analysis
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