Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome
Abstract The aim of this study was to investigate the possible role of follicular helper T (TFH ) cells in the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. We enrolled 50 pSS patients and...
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| Veröffentlicht in: | Clinical immunology (Orlando, Fla.) Fla.), 2013-05, Vol.147 (2), p.95-104 |
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| creator | Szabo, Krisztina Papp, Gabor Barath, Sandor Gyimesi, Edit Szanto, Antonia Zeher, Margit |
| description | Abstract The aim of this study was to investigate the possible role of follicular helper T (TFH ) cells in the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. We enrolled 50 pSS patients and 16 healthy individuals in the study. Patients had elevated ratio of peripheral TFH cells, however, when dividing patients into two groups defined by the presence of extraglandular manifestations (EGMs), only patients with EGMs differed from controls significantly. Moreover, TFH cell percentages correlated positively with both activated T cell and Tr1 cell values. On the contrary, TFH cell percentages showed negative correlation with both IgM and IgG memory B cell proportions. Elevated TFH percent\ages were observed in the anti-SSA/SSB positive patients, and also in patients with higher IL-12, IL-21 levels and focus score values. Increased TFH cell proportions seem to have an important role in disease development. |
| doi_str_mv | 10.1016/j.clim.2013.02.024 |
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We enrolled 50 pSS patients and 16 healthy individuals in the study. Patients had elevated ratio of peripheral TFH cells, however, when dividing patients into two groups defined by the presence of extraglandular manifestations (EGMs), only patients with EGMs differed from controls significantly. Moreover, TFH cell percentages correlated positively with both activated T cell and Tr1 cell values. On the contrary, TFH cell percentages showed negative correlation with both IgM and IgG memory B cell proportions. Elevated TFH percent\ages were observed in the anti-SSA/SSB positive patients, and also in patients with higher IL-12, IL-21 levels and focus score values. Increased TFH cell proportions seem to have an important role in disease development.</description><identifier>ISSN: 1521-6616</identifier><identifier>EISSN: 1521-7035</identifier><identifier>DOI: 10.1016/j.clim.2013.02.024</identifier><identifier>PMID: 23578551</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activated T cells ; Aged ; Allergy and Immunology ; Autoantibodies ; Autoantibodies - immunology ; Autoantigens - immunology ; Case-Control Studies ; Cytokines - blood ; Female ; Follicular helper T cells (TFH) ; Humans ; Male ; Memory B cells ; Middle Aged ; Primary Sjögren's syndrome (pSS) ; Ribonucleoproteins - immunology ; Sjogren's Syndrome - immunology ; SS-B Antigen ; T-Lymphocytes, Helper-Inducer - immunology</subject><ispartof>Clinical immunology (Orlando, Fla.), 2013-05, Vol.147 (2), p.95-104</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-a58d7f25ff9b205e899ab7566853343cfd59620bf4b95cc99708cce2f9be112b3</citedby><cites>FETCH-LOGICAL-c411t-a58d7f25ff9b205e899ab7566853343cfd59620bf4b95cc99708cce2f9be112b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clim.2013.02.024$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23578551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szabo, Krisztina</creatorcontrib><creatorcontrib>Papp, Gabor</creatorcontrib><creatorcontrib>Barath, Sandor</creatorcontrib><creatorcontrib>Gyimesi, Edit</creatorcontrib><creatorcontrib>Szanto, Antonia</creatorcontrib><creatorcontrib>Zeher, Margit</creatorcontrib><title>Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome</title><title>Clinical immunology (Orlando, Fla.)</title><addtitle>Clin Immunol</addtitle><description>Abstract The aim of this study was to investigate the possible role of follicular helper T (TFH ) cells in the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. We enrolled 50 pSS patients and 16 healthy individuals in the study. Patients had elevated ratio of peripheral TFH cells, however, when dividing patients into two groups defined by the presence of extraglandular manifestations (EGMs), only patients with EGMs differed from controls significantly. Moreover, TFH cell percentages correlated positively with both activated T cell and Tr1 cell values. On the contrary, TFH cell percentages showed negative correlation with both IgM and IgG memory B cell proportions. Elevated TFH percent\ages were observed in the anti-SSA/SSB positive patients, and also in patients with higher IL-12, IL-21 levels and focus score values. Increased TFH cell proportions seem to have an important role in disease development.</description><subject>Activated T cells</subject><subject>Aged</subject><subject>Allergy and Immunology</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Autoantigens - immunology</subject><subject>Case-Control Studies</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>Follicular helper T cells (TFH)</subject><subject>Humans</subject><subject>Male</subject><subject>Memory B cells</subject><subject>Middle Aged</subject><subject>Primary Sjögren's syndrome (pSS)</subject><subject>Ribonucleoproteins - immunology</subject><subject>Sjogren's Syndrome - immunology</subject><subject>SS-B Antigen</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><issn>1521-6616</issn><issn>1521-7035</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1q3TAUhUVoaP66gQ6KZu3kvejHkm0ohRCathDIIMlYyPJ1IleWXMkOeGPZQDYWmffaQQeBi6TBdy465yD0kZItJVSe91vj7LBlhPItYXmKA3RMBaObknDxbv-WksojdJJSTwgRjMn36IhxUVZC0GNkroJz1sxOR_wIboSI77AB5xIe9IJHlw_tsR3GECftJxyDA2w9nh4BJ3iCaKcFhw6P0Q46Lvi2f3l-iOA_J5wW38YwwBk67LRL8GF_n6L7q-93lz831zc_fl1eXG9MQem00aJqy46JrqsbRgRUda2bUkhZCc4LbrpW1JKRpiuaWhhT1yWpjAGWcaCUNfwUfdntHWP4M0Oa1GDT6kV7CHNSlBfZMxGiyijboSaGlCJ0av9_RYlaw1W9WsNVa7iKsDxFFn3a75-bAdp_kr9pZuDrDoDs8slCVMlY8AZaG8FMqg327f3f_pNnxFuj3W9YIPVhjj7np6hKWaBu13rXdinPzUou-Ss_daDf</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Szabo, Krisztina</creator><creator>Papp, Gabor</creator><creator>Barath, Sandor</creator><creator>Gyimesi, Edit</creator><creator>Szanto, Antonia</creator><creator>Zeher, Margit</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome</title><author>Szabo, Krisztina ; Papp, Gabor ; Barath, Sandor ; Gyimesi, Edit ; Szanto, Antonia ; Zeher, Margit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-a58d7f25ff9b205e899ab7566853343cfd59620bf4b95cc99708cce2f9be112b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Activated T cells</topic><topic>Aged</topic><topic>Allergy and Immunology</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Autoantigens - immunology</topic><topic>Case-Control Studies</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>Follicular helper T cells (TFH)</topic><topic>Humans</topic><topic>Male</topic><topic>Memory B cells</topic><topic>Middle Aged</topic><topic>Primary Sjögren's syndrome (pSS)</topic><topic>Ribonucleoproteins - immunology</topic><topic>Sjogren's Syndrome - immunology</topic><topic>SS-B Antigen</topic><topic>T-Lymphocytes, Helper-Inducer - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szabo, Krisztina</creatorcontrib><creatorcontrib>Papp, Gabor</creatorcontrib><creatorcontrib>Barath, Sandor</creatorcontrib><creatorcontrib>Gyimesi, Edit</creatorcontrib><creatorcontrib>Szanto, Antonia</creatorcontrib><creatorcontrib>Zeher, Margit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szabo, Krisztina</au><au>Papp, Gabor</au><au>Barath, Sandor</au><au>Gyimesi, Edit</au><au>Szanto, Antonia</au><au>Zeher, Margit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome</atitle><jtitle>Clinical immunology (Orlando, Fla.)</jtitle><addtitle>Clin Immunol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>147</volume><issue>2</issue><spage>95</spage><epage>104</epage><pages>95-104</pages><issn>1521-6616</issn><eissn>1521-7035</eissn><abstract>Abstract The aim of this study was to investigate the possible role of follicular helper T (TFH ) cells in the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent cells and serological markers with special emphasis on clinical symptoms. 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| subjects | Activated T cells Aged Allergy and Immunology Autoantibodies Autoantibodies - immunology Autoantigens - immunology Case-Control Studies Cytokines - blood Female Follicular helper T cells (TFH) Humans Male Memory B cells Middle Aged Primary Sjögren's syndrome (pSS) Ribonucleoproteins - immunology Sjogren's Syndrome - immunology SS-B Antigen T-Lymphocytes, Helper-Inducer - immunology |
| title | Follicular helper T cells may play an important role in the severity of primary Sjögren's syndrome |
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