Postsurgical Intrapericardial Adhesions: Mechanisms of Formation and Prevention
Postsurgical intrapericardial adhesions are still considered an unavoidable consequence of cardiothoracic operations. They increase the technical difficulty and the risk of reoperations. The pathogenesis of postsurgical adhesions is a multistep process, and the main key players are (1) loss of mesot...
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| Veröffentlicht in: | The Annals of thoracic surgery 2013-05, Vol.95 (5), p.1818-1826 |
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| container_title | The Annals of thoracic surgery |
| container_volume | 95 |
| creator | Cannata, Aldo, MD Petrella, Duccio, MD Russo, Claudio Francesco, MD Bruschi, Giuseppe, MD Fratto, Pasquale, MD Gambacorta, Marcello, MD Martinelli, Luigi, MD |
| description | Postsurgical intrapericardial adhesions are still considered an unavoidable consequence of cardiothoracic operations. They increase the technical difficulty and the risk of reoperations. The pathogenesis of postsurgical adhesions is a multistep process, and the main key players are (1) loss of mesothelial cells, (2) accumulation of fibrin in areas devoid of mesothelial cells, (3) loss of normal pericardial fibrinolysis, and (4) local inflammation. Today, very promising methods to reduce adhesions are available for clinical use. This report reviews the process of formation of adhesions and the methods to prevent them, classified according to the mechanism of action. |
| doi_str_mv | 10.1016/j.athoracsur.2012.11.020 |
| format | Article |
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They increase the technical difficulty and the risk of reoperations. The pathogenesis of postsurgical adhesions is a multistep process, and the main key players are (1) loss of mesothelial cells, (2) accumulation of fibrin in areas devoid of mesothelial cells, (3) loss of normal pericardial fibrinolysis, and (4) local inflammation. Today, very promising methods to reduce adhesions are available for clinical use. This report reviews the process of formation of adhesions and the methods to prevent them, classified according to the mechanism of action.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2012.11.020</identifier><identifier>PMID: 23566646</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Cardiothoracic Surgery ; Fibroblast Growth Factor 7 - therapeutic use ; Humans ; Hyaluronic Acid - administration & dosage ; Inflammation - prevention & control ; Pericardium - pathology ; Polytetrafluoroethylene ; Postoperative Complications - etiology ; Surgery ; Tissue Adhesions - etiology ; Tissue Adhesions - prevention & control</subject><ispartof>The Annals of thoracic surgery, 2013-05, Vol.95 (5), p.1818-1826</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2013 The Society of Thoracic Surgeons</rights><rights>Copyright © 2013 The Society of Thoracic Surgeons. 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| fulltext | fulltext |
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| ispartof | The Annals of thoracic surgery, 2013-05, Vol.95 (5), p.1818-1826 |
| issn | 0003-4975 1552-6259 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Cardiothoracic Surgery Fibroblast Growth Factor 7 - therapeutic use Humans Hyaluronic Acid - administration & dosage Inflammation - prevention & control Pericardium - pathology Polytetrafluoroethylene Postoperative Complications - etiology Surgery Tissue Adhesions - etiology Tissue Adhesions - prevention & control |
| title | Postsurgical Intrapericardial Adhesions: Mechanisms of Formation and Prevention |
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