Silencing of GLUT-1 inhibits sensitization of oral cancer cells to cisplatin during hypoxia

Background During tumor development, cells are exposed to a hypoxic microenvironment. Tumor hypoxia also has a profound influence on the sensitivity of cancer chemotherapy. The objective of this study was to investigate the mechanism of cisplatin (CDDP) resistance of oral squamous cell carcinoma (OS...

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Veröffentlicht in:	Journal of oral pathology & medicine 2013-05, Vol.42 (5), p.382-388
Hauptverfasser:	Shimanishi, Makoto, Ogi, Kazuhiro, Sogabe, Yohei, Kaneko, Takeshi, Dehari, Hironari, Miyazaki, Akihiro, Hiratsuka, Hiroyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis - drug effects Basic Helix-Loop-Helix Transcription Factors - genetics Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cell Culture Techniques Cell Death - drug effects Cell Death - genetics Cell Hypoxia - physiology Cell Line, Tumor Cell Proliferation Cell Survival - drug effects cisplatin (CDDP) Cisplatin - therapeutic use Dentistry Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Profiling Gene Knockdown Techniques Gene Silencing Glucose Transporter Type 1 - genetics glucose transporter-1(GLUT-1) Humans hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - genetics Mouth Neoplasms - drug therapy Mouth Neoplasms - genetics Mouth Neoplasms - pathology oral squamous cell carcinoma RNA, Small Interfering - genetics Tongue Neoplasms - drug therapy Tongue Neoplasms - pathology Tumor Microenvironment - drug effects Tumor Microenvironment - genetics
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