Allosteric Effects in the Regulation of 26S Proteasome Activities

The 26S proteasome is the executive arm of the ubiquitin-proteasome system. This 2.5-MDa complex comprising the 20S core particle (CP) and the 19S regulatory particle (RP) is able to effectively execute its function due to a tightly regulated network of allosteric interactions. From this perspective...

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Veröffentlicht in:	Journal of molecular biology 2013-05, Vol.425 (9), p.1415-1423
Hauptverfasser:	Śledź, Paweł, Förster, Friedrich, Baumeister, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	26S proteasome Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - metabolism adenosine triphosphate Allosteric Regulation allostery cryo-electron microscopy Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Humans hydrolysis Models, Molecular proteasome endopeptidase complex Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - metabolism proteolysis proteostasis
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