Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk
Small components and metabolites in milk are significant for the utilization of milk, not only in dairy food production but also as disease predictors in dairy cattle. This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For...
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| Veröffentlicht in: | Journal of dairy science 2013-05, Vol.96 (5), p.3285-3295 |
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| creator | Buitenhuis, A.J. Sundekilde, U.K. Poulsen, N.A. Bertram, H.C. Larsen, L.B. Sørensen, P. |
| description | Small components and metabolites in milk are significant for the utilization of milk, not only in dairy food production but also as disease predictors in dairy cattle. This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For this purpose, milk samples were collected in mid lactation from 371 Danish Holstein cows in first to third parity. A total of 31 metabolites were detected and identified in bovine milk by using 1H nuclear magnetic resonance (NMR) spectroscopy. Cows were genotyped using a bovine high-density single nucleotide polymorphism (SNP) chip. Based on the SNP data, a genomic relationship matrix was calculated and used as a random factor in a model together with 2 fixed factors (herd and lactation stage) to estimate the heritability and breeding value for individual metabolites in the milk. Heritability was in the range of 0 for lactic acid to >0.8 for orotic acid and β-hydroxybutyrate. A single SNP association analysis revealed 7 genome-wide significant quantitative trait loci [malonate: Bos taurus autosome (BTA)2 and BTA7; galactose-1-phosphate: BTA2; cis-aconitate: BTA11; urea: BTA12; carnitine: BTA25; and glycerophosphocholine: BTA25]. These results demonstrate that selection for metabolites in bovine milk may be possible. |
| doi_str_mv | 10.3168/jds.2012-5914 |
| format | Article |
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This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For this purpose, milk samples were collected in mid lactation from 371 Danish Holstein cows in first to third parity. A total of 31 metabolites were detected and identified in bovine milk by using 1H nuclear magnetic resonance (NMR) spectroscopy. Cows were genotyped using a bovine high-density single nucleotide polymorphism (SNP) chip. Based on the SNP data, a genomic relationship matrix was calculated and used as a random factor in a model together with 2 fixed factors (herd and lactation stage) to estimate the heritability and breeding value for individual metabolites in the milk. Heritability was in the range of 0 for lactic acid to >0.8 for orotic acid and β-hydroxybutyrate. A single SNP association analysis revealed 7 genome-wide significant quantitative trait loci [malonate: Bos taurus autosome (BTA)2 and BTA7; galactose-1-phosphate: BTA2; cis-aconitate: BTA11; urea: BTA12; carnitine: BTA25; and glycerophosphocholine: BTA25]. These results demonstrate that selection for metabolites in bovine milk may be possible.</description><identifier>ISSN: 0022-0302</identifier><identifier>EISSN: 1525-3198</identifier><identifier>DOI: 10.3168/jds.2012-5914</identifier><identifier>PMID: 23497994</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3-hydroxybutyric acid ; Animals ; bovine milk ; breeding value ; carnitine ; Cattle - genetics ; cows ; dairy cattle ; Female ; food production ; Genotyping Techniques - veterinary ; herds ; heritability ; Holstein ; Lactation - genetics ; lactation stage ; lactic acid ; Magnetic Resonance Spectroscopy ; metabolite ; metabolites ; milk ; Milk - chemistry ; nuclear magnetic resonance spectroscopy ; Oligonucleotide Array Sequence Analysis - veterinary ; orotic acid ; Polymorphism, Single Nucleotide - genetics ; quantitative trait loci ; Quantitative Trait Loci - genetics ; single nucleotide polymorphism ; urea</subject><ispartof>Journal of dairy science, 2013-05, Vol.96 (5), p.3285-3295</ispartof><rights>2013 American Dairy Science Association</rights><rights>Copyright © 2013 American Dairy Science Association. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-2035b36abfd83de8239c308f19b7e672d329051b52f784d2ecbe83aec539c95c3</citedby><cites>FETCH-LOGICAL-c404t-2035b36abfd83de8239c308f19b7e672d329051b52f784d2ecbe83aec539c95c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3168/jds.2012-5914$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23497994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buitenhuis, A.J.</creatorcontrib><creatorcontrib>Sundekilde, U.K.</creatorcontrib><creatorcontrib>Poulsen, N.A.</creatorcontrib><creatorcontrib>Bertram, H.C.</creatorcontrib><creatorcontrib>Larsen, L.B.</creatorcontrib><creatorcontrib>Sørensen, P.</creatorcontrib><title>Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>Small components and metabolites in milk are significant for the utilization of milk, not only in dairy food production but also as disease predictors in dairy cattle. This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For this purpose, milk samples were collected in mid lactation from 371 Danish Holstein cows in first to third parity. A total of 31 metabolites were detected and identified in bovine milk by using 1H nuclear magnetic resonance (NMR) spectroscopy. Cows were genotyped using a bovine high-density single nucleotide polymorphism (SNP) chip. Based on the SNP data, a genomic relationship matrix was calculated and used as a random factor in a model together with 2 fixed factors (herd and lactation stage) to estimate the heritability and breeding value for individual metabolites in the milk. Heritability was in the range of 0 for lactic acid to >0.8 for orotic acid and β-hydroxybutyrate. A single SNP association analysis revealed 7 genome-wide significant quantitative trait loci [malonate: Bos taurus autosome (BTA)2 and BTA7; galactose-1-phosphate: BTA2; cis-aconitate: BTA11; urea: BTA12; carnitine: BTA25; and glycerophosphocholine: BTA25]. These results demonstrate that selection for metabolites in bovine milk may be possible.</description><subject>3-hydroxybutyric acid</subject><subject>Animals</subject><subject>bovine milk</subject><subject>breeding value</subject><subject>carnitine</subject><subject>Cattle - genetics</subject><subject>cows</subject><subject>dairy cattle</subject><subject>Female</subject><subject>food production</subject><subject>Genotyping Techniques - veterinary</subject><subject>herds</subject><subject>heritability</subject><subject>Holstein</subject><subject>Lactation - genetics</subject><subject>lactation stage</subject><subject>lactic acid</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>metabolite</subject><subject>metabolites</subject><subject>milk</subject><subject>Milk - chemistry</subject><subject>nuclear magnetic resonance spectroscopy</subject><subject>Oligonucleotide Array Sequence Analysis - veterinary</subject><subject>orotic acid</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>quantitative trait loci</subject><subject>Quantitative Trait Loci - genetics</subject><subject>single nucleotide polymorphism</subject><subject>urea</subject><issn>0022-0302</issn><issn>1525-3198</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtPAyEURonRaK0u3SpLN6M8hg4sje_ExIV2TRi4U9GZoQVq4r-XpurOzeXe5HwfyUHohJILTmfy8t2lC0Yoq4Si9Q6aUMFExamSu2hCCGMV4YQdoMOU3stJGRH76IDxWjVK1RO0uk3ZDyb7MOLQ4QWMkL3FSxPNABliwmZ02JXV_jKrtRmzzyXzCThH4zPug_W4CxGXjGlD7zMk7Ed8Y0af3vBD6FOGcg--_zhCe53pExz_vFM0v7t9vX6onp7vH6-vnipbkzpXjHDR8plpOye5A8m4spzIjqq2gVnDHGeKCNoK1jWydgxsC5IbsKKASlg-Refb3mUMqzWkrAefLPS9GSGsk6acS664LM1TVG1RG0NKETq9jEVK_NKU6I1lXSzrjWW9sVz405_qdTuA-6N_tRbgbAt0JmiziD7p-UvJC0JomWxWiGZLQFHw6SHqZD2MFpyPRbV2wf_z-TeSNJWs</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Buitenhuis, A.J.</creator><creator>Sundekilde, U.K.</creator><creator>Poulsen, N.A.</creator><creator>Bertram, H.C.</creator><creator>Larsen, L.B.</creator><creator>Sørensen, P.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk</title><author>Buitenhuis, A.J. ; Sundekilde, U.K. ; Poulsen, N.A. ; Bertram, H.C. ; Larsen, L.B. ; Sørensen, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-2035b36abfd83de8239c308f19b7e672d329051b52f784d2ecbe83aec539c95c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>3-hydroxybutyric acid</topic><topic>Animals</topic><topic>bovine milk</topic><topic>breeding value</topic><topic>carnitine</topic><topic>Cattle - genetics</topic><topic>cows</topic><topic>dairy cattle</topic><topic>Female</topic><topic>food production</topic><topic>Genotyping Techniques - veterinary</topic><topic>herds</topic><topic>heritability</topic><topic>Holstein</topic><topic>Lactation - genetics</topic><topic>lactation stage</topic><topic>lactic acid</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>metabolite</topic><topic>metabolites</topic><topic>milk</topic><topic>Milk - chemistry</topic><topic>nuclear magnetic resonance spectroscopy</topic><topic>Oligonucleotide Array Sequence Analysis - veterinary</topic><topic>orotic acid</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>quantitative trait loci</topic><topic>Quantitative Trait Loci - genetics</topic><topic>single nucleotide polymorphism</topic><topic>urea</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buitenhuis, A.J.</creatorcontrib><creatorcontrib>Sundekilde, U.K.</creatorcontrib><creatorcontrib>Poulsen, N.A.</creatorcontrib><creatorcontrib>Bertram, H.C.</creatorcontrib><creatorcontrib>Larsen, L.B.</creatorcontrib><creatorcontrib>Sørensen, P.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buitenhuis, A.J.</au><au>Sundekilde, U.K.</au><au>Poulsen, N.A.</au><au>Bertram, H.C.</au><au>Larsen, L.B.</au><au>Sørensen, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>96</volume><issue>5</issue><spage>3285</spage><epage>3295</epage><pages>3285-3295</pages><issn>0022-0302</issn><eissn>1525-3198</eissn><abstract>Small components and metabolites in milk are significant for the utilization of milk, not only in dairy food production but also as disease predictors in dairy cattle. This study focused on estimation of genetic parameters and detection of quantitative trait loci for metabolites in bovine milk. For this purpose, milk samples were collected in mid lactation from 371 Danish Holstein cows in first to third parity. A total of 31 metabolites were detected and identified in bovine milk by using 1H nuclear magnetic resonance (NMR) spectroscopy. Cows were genotyped using a bovine high-density single nucleotide polymorphism (SNP) chip. Based on the SNP data, a genomic relationship matrix was calculated and used as a random factor in a model together with 2 fixed factors (herd and lactation stage) to estimate the heritability and breeding value for individual metabolites in the milk. Heritability was in the range of 0 for lactic acid to >0.8 for orotic acid and β-hydroxybutyrate. A single SNP association analysis revealed 7 genome-wide significant quantitative trait loci [malonate: Bos taurus autosome (BTA)2 and BTA7; galactose-1-phosphate: BTA2; cis-aconitate: BTA11; urea: BTA12; carnitine: BTA25; and glycerophosphocholine: BTA25]. These results demonstrate that selection for metabolites in bovine milk may be possible.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23497994</pmid><doi>10.3168/jds.2012-5914</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 3-hydroxybutyric acid Animals bovine milk breeding value carnitine Cattle - genetics cows dairy cattle Female food production Genotyping Techniques - veterinary herds heritability Holstein Lactation - genetics lactation stage lactic acid Magnetic Resonance Spectroscopy metabolite metabolites milk Milk - chemistry nuclear magnetic resonance spectroscopy Oligonucleotide Array Sequence Analysis - veterinary orotic acid Polymorphism, Single Nucleotide - genetics quantitative trait loci Quantitative Trait Loci - genetics single nucleotide polymorphism urea |
| title | Estimation of genetic parameters and detection of quantitative trait loci for metabolites in Danish Holstein milk |
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