MiRNA‐362‐3p induces cell cycle arrest through targeting of E2F1, USF2 and PTPN1 and is associated with recurrence of colorectal cancer

Colorectal cancer (CRC) is one of the leading causes of cancer deaths in Western countries. A significant number of CRC patients undergoing curatively intended surgery subsequently develop recurrence and die from the disease. MicroRNAs (miRNAs) are aberrantly expressed in cancers and appear to have...

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Veröffentlicht in:	International journal of cancer 2013-07, Vol.133 (1), p.67-78
Hauptverfasser:	Christensen, Lise Lotte, Tobiasen, Heidi, Holm, Anja, Schepeler, Troels, Ostenfeld, Marie S, Thorsen, Kasper, Rasmussen, Mads H., Birkenkamp‐Demtroeder, Karin, Sieber, Oliver M., Gibbs, Peter, Lubinski, Jan, Lamy, Philippe, Laurberg, Søren, Øster, Bodil, Hansen, Kristian Q., Hagemann‐Madsen, Rikke, Byskov, Kristina, Ørntoft, Torben F., Andersen, Claus L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Cancer Cell cycle Cell Cycle Checkpoints Cell Proliferation Cell Survival Colon - metabolism Colon - pathology Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology E2F1 Transcription Factor - genetics E2F1 Transcription Factor - metabolism Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Intestinal Mucosa - metabolism Male Medical sciences MicroRNAs MicroRNAs - metabolism Middle Aged miRNA expression profiling miR‐362‐3p Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Polymerase Chain Reaction - methods Prognosis Proportional Hazards Models Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism Recurrence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus target identification Tumors Up-Regulation Upstream Stimulatory Factors - genetics Upstream Stimulatory Factors - metabolism
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