ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons

•ATP13A2 is a lysosomal protein but some disease-associated variants remain in the endoplasmic reticulum.•Loss of ATP13A2 function in cells results in cell death, cathepsin D reduction and fingerprint-like structures.•Atp13a2 mutant medaka discloses dopaminergic cell death, cathepsin D reduction and...

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