Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model
Background. Irritant contact dermatitis remains a substantial problem in the food processing industries. Irritants that are weak by themselves, such as glove occlusion and mild detergents, could interact to produce contact dermatitis. Objectives. To model the irritant action of an antibacterial hand...
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| Veröffentlicht in: | Contact dermatitis 2013-05, Vol.68 (5), p.293-299 |
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| creator | Antonov, Dimitar Kleesz, Peter Elsner, Peter Schliemann, Sibylle |
| description | Background. Irritant contact dermatitis remains a substantial problem in the food processing industries. Irritants that are weak by themselves, such as glove occlusion and mild detergents, could interact to produce contact dermatitis.
Objectives. To model the irritant action of an antibacterial hand cleanser and glove occlusion, with sodium lauryl sulfate (SLS) as a positive control. The effects of a pre‐exposure cream and a post‐exposure cream were also investigated.
Methods. A modified repeated short‐time occlusive irritation test with 20 healthy volunteers, and application of irritants over 4 days, with pre‐exposure and post‐exposure creams and overnight glove occlusion, was performed. The changes in transepidermal water loss (TEWL) served as a measure of the irritant damage to the epidermal barrier.
Results. The antibacterial cleanser and the glove occlusion separately induced only minor increases in TEWL. When combined, the two showed a tandem effect, as the TEWL increase was significantly higher, and was similar to that seen with the positive control, SLS. The pre‐exposure and post‐exposure creams alone significantly mitigated the cumulative irritation, and this effect was strongest when the two creams were combined.
Conclusions. Irritant contact dermatitis may develop through the tandem effects of long‐term glove occlusion and the accumulation of barrier damage from hand washing, even when mild hand cleansers are employed. |
| doi_str_mv | 10.1111/cod.12028 |
| format | Article |
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Objectives. To model the irritant action of an antibacterial hand cleanser and glove occlusion, with sodium lauryl sulfate (SLS) as a positive control. The effects of a pre‐exposure cream and a post‐exposure cream were also investigated.
Methods. A modified repeated short‐time occlusive irritation test with 20 healthy volunteers, and application of irritants over 4 days, with pre‐exposure and post‐exposure creams and overnight glove occlusion, was performed. The changes in transepidermal water loss (TEWL) served as a measure of the irritant damage to the epidermal barrier.
Results. The antibacterial cleanser and the glove occlusion separately induced only minor increases in TEWL. When combined, the two showed a tandem effect, as the TEWL increase was significantly higher, and was similar to that seen with the positive control, SLS. The pre‐exposure and post‐exposure creams alone significantly mitigated the cumulative irritation, and this effect was strongest when the two creams were combined.
Conclusions. Irritant contact dermatitis may develop through the tandem effects of long‐term glove occlusion and the accumulation of barrier damage from hand washing, even when mild hand cleansers are employed.</description><identifier>ISSN: 0105-1873</identifier><identifier>EISSN: 1600-0536</identifier><identifier>DOI: 10.1111/cod.12028</identifier><identifier>PMID: 23343466</identifier><identifier>CODEN: CODEDG</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Allergic diseases ; Anti-Infective Agents, Local - administration & dosage ; Anti-Infective Agents, Local - adverse effects ; Biological and medical sciences ; Dermatitis ; Dermatitis, Irritant - etiology ; detergents ; Female ; Gloves, Protective - adverse effects ; Hand Dermatoses - etiology ; Hand Disinfection - methods ; Humans ; Immunopathology ; irritant contact dermatitis ; Male ; Medical sciences ; Models, Biological ; non-invasive measuring methods ; occupational ; Occupational medicine ; Public health. Hygiene-occupational medicine ; Single-Blind Method ; Skin - drug effects ; Skin allergic diseases. Stinging insect allergies ; skin barrier ; Skin Cream - administration & dosage ; Skin Cream - adverse effects ; Young Adult</subject><ispartof>Contact dermatitis, 2013-05, Vol.68 (5), p.293-299</ispartof><rights>2013 John Wiley & Sons A/S</rights><rights>2014 INIST-CNRS</rights><rights>2013 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3368-9e0672e5a83a57c881553ff968bda37aa29e552791be7923b842f407b94f8ffc3</citedby><cites>FETCH-LOGICAL-c3368-9e0672e5a83a57c881553ff968bda37aa29e552791be7923b842f407b94f8ffc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcod.12028$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcod.12028$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27243103$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23343466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Antonov, Dimitar</creatorcontrib><creatorcontrib>Kleesz, Peter</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><creatorcontrib>Schliemann, Sibylle</creatorcontrib><title>Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model</title><title>Contact dermatitis</title><addtitle>Contact Dermatitis</addtitle><description>Background. Irritant contact dermatitis remains a substantial problem in the food processing industries. Irritants that are weak by themselves, such as glove occlusion and mild detergents, could interact to produce contact dermatitis.
Objectives. To model the irritant action of an antibacterial hand cleanser and glove occlusion, with sodium lauryl sulfate (SLS) as a positive control. The effects of a pre‐exposure cream and a post‐exposure cream were also investigated.
Methods. A modified repeated short‐time occlusive irritation test with 20 healthy volunteers, and application of irritants over 4 days, with pre‐exposure and post‐exposure creams and overnight glove occlusion, was performed. The changes in transepidermal water loss (TEWL) served as a measure of the irritant damage to the epidermal barrier.
Results. The antibacterial cleanser and the glove occlusion separately induced only minor increases in TEWL. When combined, the two showed a tandem effect, as the TEWL increase was significantly higher, and was similar to that seen with the positive control, SLS. The pre‐exposure and post‐exposure creams alone significantly mitigated the cumulative irritation, and this effect was strongest when the two creams were combined.
Conclusions. Irritant contact dermatitis may develop through the tandem effects of long‐term glove occlusion and the accumulation of barrier damage from hand washing, even when mild hand cleansers are employed.</description><subject>Adult</subject><subject>Allergic diseases</subject><subject>Anti-Infective Agents, Local - administration & dosage</subject><subject>Anti-Infective Agents, Local - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Dermatitis</subject><subject>Dermatitis, Irritant - etiology</subject><subject>detergents</subject><subject>Female</subject><subject>Gloves, Protective - adverse effects</subject><subject>Hand Dermatoses - etiology</subject><subject>Hand Disinfection - methods</subject><subject>Humans</subject><subject>Immunopathology</subject><subject>irritant contact dermatitis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>non-invasive measuring methods</subject><subject>occupational</subject><subject>Occupational medicine</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Single-Blind Method</subject><subject>Skin - drug effects</subject><subject>Skin allergic diseases. Stinging insect allergies</subject><subject>skin barrier</subject><subject>Skin Cream - administration & dosage</subject><subject>Skin Cream - adverse effects</subject><subject>Young Adult</subject><issn>0105-1873</issn><issn>1600-0536</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhiMEokNhwQsgSwgJFml9iS9ZwhSmlSq64LqzPM4xdevEwU5o-xB955rOtCAkLEtHx_7-_9j6q-o5wXukrH0buz1CMVUPqgURGNeYM_GwWmCCeU2UZDvVk5zPMCaioepxtUMZa1gjxKK6PupHYycUHfoR4i9A0dowZx8HVLad-zmYyZfzfO4H5FPyU-nL1YWfTlFMtzXOEzo1Q4dsADNkSLWNxTb5XMAiMwOCyxGS72GYTEAJRjATdH_79bGD8LR65EzI8Gxbd6svH95_Xh7Wxyero-Xb49oyJlTdAhaSAjeKGS6tUoRz5lwr1LozTBpDW-CcypasQbaUrVVDXYPlum2ccs6y3er1xndM8ecMedK9zxZCMAPEOWvCmGItKbKCvvwHPYtzGsrrNOG0FVK1hBfqzYayKeacwOmx_NakK02w_p2RLhnp24wK-2LrOK976O7Ju1AK8GoLmGxNcMkM1uc_nKQNI5gVbn_DXfgAV_-fqJcnB3ej643C5wku7xUmnWshmeT628eVXn09-K4-sXf6kN0AkUO48g</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Antonov, Dimitar</creator><creator>Kleesz, Peter</creator><creator>Elsner, Peter</creator><creator>Schliemann, Sibylle</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model</title><author>Antonov, Dimitar ; Kleesz, Peter ; Elsner, Peter ; Schliemann, Sibylle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3368-9e0672e5a83a57c881553ff968bda37aa29e552791be7923b842f407b94f8ffc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Allergic diseases</topic><topic>Anti-Infective Agents, Local - administration & dosage</topic><topic>Anti-Infective Agents, Local - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Dermatitis</topic><topic>Dermatitis, Irritant - etiology</topic><topic>detergents</topic><topic>Female</topic><topic>Gloves, Protective - adverse effects</topic><topic>Hand Dermatoses - etiology</topic><topic>Hand Disinfection - methods</topic><topic>Humans</topic><topic>Immunopathology</topic><topic>irritant contact dermatitis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>non-invasive measuring methods</topic><topic>occupational</topic><topic>Occupational medicine</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Single-Blind Method</topic><topic>Skin - drug effects</topic><topic>Skin allergic diseases. Stinging insect allergies</topic><topic>skin barrier</topic><topic>Skin Cream - administration & dosage</topic><topic>Skin Cream - adverse effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Antonov, Dimitar</creatorcontrib><creatorcontrib>Kleesz, Peter</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><creatorcontrib>Schliemann, Sibylle</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Contact dermatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Antonov, Dimitar</au><au>Kleesz, Peter</au><au>Elsner, Peter</au><au>Schliemann, Sibylle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model</atitle><jtitle>Contact dermatitis</jtitle><addtitle>Contact Dermatitis</addtitle><date>2013-05</date><risdate>2013</risdate><volume>68</volume><issue>5</issue><spage>293</spage><epage>299</epage><pages>293-299</pages><issn>0105-1873</issn><eissn>1600-0536</eissn><coden>CODEDG</coden><abstract>Background. Irritant contact dermatitis remains a substantial problem in the food processing industries. Irritants that are weak by themselves, such as glove occlusion and mild detergents, could interact to produce contact dermatitis.
Objectives. To model the irritant action of an antibacterial hand cleanser and glove occlusion, with sodium lauryl sulfate (SLS) as a positive control. The effects of a pre‐exposure cream and a post‐exposure cream were also investigated.
Methods. A modified repeated short‐time occlusive irritation test with 20 healthy volunteers, and application of irritants over 4 days, with pre‐exposure and post‐exposure creams and overnight glove occlusion, was performed. The changes in transepidermal water loss (TEWL) served as a measure of the irritant damage to the epidermal barrier.
Results. The antibacterial cleanser and the glove occlusion separately induced only minor increases in TEWL. When combined, the two showed a tandem effect, as the TEWL increase was significantly higher, and was similar to that seen with the positive control, SLS. The pre‐exposure and post‐exposure creams alone significantly mitigated the cumulative irritation, and this effect was strongest when the two creams were combined.
Conclusions. Irritant contact dermatitis may develop through the tandem effects of long‐term glove occlusion and the accumulation of barrier damage from hand washing, even when mild hand cleansers are employed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>23343466</pmid><doi>10.1111/cod.12028</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Allergic diseases Anti-Infective Agents, Local - administration & dosage Anti-Infective Agents, Local - adverse effects Biological and medical sciences Dermatitis Dermatitis, Irritant - etiology detergents Female Gloves, Protective - adverse effects Hand Dermatoses - etiology Hand Disinfection - methods Humans Immunopathology irritant contact dermatitis Male Medical sciences Models, Biological non-invasive measuring methods occupational Occupational medicine Public health. Hygiene-occupational medicine Single-Blind Method Skin - drug effects Skin allergic diseases. Stinging insect allergies skin barrier Skin Cream - administration & dosage Skin Cream - adverse effects Young Adult |
| title | Impact of glove occlusion on cumulative skin irritation with or without hand cleanser-comparison in an experimental repeated irritation model |
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