Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice
•Tenuigenin improves Y-maze learning performance in mice.•Tenuigenin enhances synaptic plasticity in hippocampal Schaffer-CA1 pathway.•Tenuigenin increases antioxidantive effect in hippocampus.•Tenuigenin inhibits hippocampal AChE activity. Polygala tenuifolia root has been used to improve memory an...
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| Veröffentlicht in: | Behavioural brain research 2013-06, Vol.246, p.111-115 |
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| creator | Huang, Jun-ni Wang, Chun-yang Wang, Xiu-li Wu, Bo-zhi Gu, Xing-yang Liu, Wen-xiao Gong, Liang-wei Xiao, Peng Li, Chu-hua |
| description | •Tenuigenin improves Y-maze learning performance in mice.•Tenuigenin enhances synaptic plasticity in hippocampal Schaffer-CA1 pathway.•Tenuigenin increases antioxidantive effect in hippocampus.•Tenuigenin inhibits hippocampal AChE activity.
Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far. In the present study, we investigated the effects of TEN on learning and memory with Y-maze test in mice. We found that oral administration of 4mg/kg TEN significantly improved learning and memory in Y-maze task. Treatment with 4mg/kg TEN markedly reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) level, and increased superoxide dismutase (SOD) activity in hippocampus. In the electrophysiological test of hippocampal brain slice, 2μg/ml TEN perfusion substantially enhanced field excitatory postsynaptic potential (fEPSP) amplitude both in basic synaptic transmission and after high frequency stimulation (HFS) in Schaffer to CA1 pathway (Scha-CA1). These results indicate that TEN enhancing learning and memory may result from inhibiting AChE activity, improving antioxidation and enhancing synaptic plasticity in mice. Therefore, TEN shows promise as a potential nootropic product in improving learning and memory. |
| doi_str_mv | 10.1016/j.bbr.2013.03.001 |
| format | Article |
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Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far. In the present study, we investigated the effects of TEN on learning and memory with Y-maze test in mice. We found that oral administration of 4mg/kg TEN significantly improved learning and memory in Y-maze task. Treatment with 4mg/kg TEN markedly reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) level, and increased superoxide dismutase (SOD) activity in hippocampus. In the electrophysiological test of hippocampal brain slice, 2μg/ml TEN perfusion substantially enhanced field excitatory postsynaptic potential (fEPSP) amplitude both in basic synaptic transmission and after high frequency stimulation (HFS) in Schaffer to CA1 pathway (Scha-CA1). These results indicate that TEN enhancing learning and memory may result from inhibiting AChE activity, improving antioxidation and enhancing synaptic plasticity in mice. Therefore, TEN shows promise as a potential nootropic product in improving learning and memory.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2013.03.001</identifier><identifier>PMID: 23499702</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Acetylcholinesterase - metabolism ; AChE activity ; Animals ; Antioxidation ; Behavior therapy. Cognitive therapy ; Behavioral psychophysiology ; Biological and medical sciences ; Discrimination Learning - drug effects ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - pharmacology ; Electric Stimulation ; Excitatory Postsynaptic Potentials - drug effects ; Fundamental and applied biological sciences. Psychology ; Hippocampus - drug effects ; In Vitro Techniques ; Male ; Malondialdehyde - metabolism ; Maze Learning - drug effects ; Medical sciences ; Memory - drug effects ; Mice ; Mice, Inbred Strains ; Neural Pathways - drug effects ; Neural Pathways - physiology ; Nootropic Agents - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Species Specificity ; Superoxide Dismutase - metabolism ; Synaptic plasticity ; Tenuigenin ; Time Factors ; Treatments ; Y-maze learning task</subject><ispartof>Behavioural brain research, 2013-06, Vol.246, p.111-115</ispartof><rights>2013 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-a26e9a029814c362494853c527d8f2377f7af933ec3ea8a3e684df70a04b06923</citedby><cites>FETCH-LOGICAL-c383t-a26e9a029814c362494853c527d8f2377f7af933ec3ea8a3e684df70a04b06923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432813001344$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27321346$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23499702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Jun-ni</creatorcontrib><creatorcontrib>Wang, Chun-yang</creatorcontrib><creatorcontrib>Wang, Xiu-li</creatorcontrib><creatorcontrib>Wu, Bo-zhi</creatorcontrib><creatorcontrib>Gu, Xing-yang</creatorcontrib><creatorcontrib>Liu, Wen-xiao</creatorcontrib><creatorcontrib>Gong, Liang-wei</creatorcontrib><creatorcontrib>Xiao, Peng</creatorcontrib><creatorcontrib>Li, Chu-hua</creatorcontrib><title>Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>•Tenuigenin improves Y-maze learning performance in mice.•Tenuigenin enhances synaptic plasticity in hippocampal Schaffer-CA1 pathway.•Tenuigenin increases antioxidantive effect in hippocampus.•Tenuigenin inhibits hippocampal AChE activity.
Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far. In the present study, we investigated the effects of TEN on learning and memory with Y-maze test in mice. We found that oral administration of 4mg/kg TEN significantly improved learning and memory in Y-maze task. Treatment with 4mg/kg TEN markedly reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) level, and increased superoxide dismutase (SOD) activity in hippocampus. In the electrophysiological test of hippocampal brain slice, 2μg/ml TEN perfusion substantially enhanced field excitatory postsynaptic potential (fEPSP) amplitude both in basic synaptic transmission and after high frequency stimulation (HFS) in Schaffer to CA1 pathway (Scha-CA1). These results indicate that TEN enhancing learning and memory may result from inhibiting AChE activity, improving antioxidation and enhancing synaptic plasticity in mice. Therefore, TEN shows promise as a potential nootropic product in improving learning and memory.</description><subject>Acetylcholinesterase - metabolism</subject><subject>AChE activity</subject><subject>Animals</subject><subject>Antioxidation</subject><subject>Behavior therapy. Cognitive therapy</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Discrimination Learning - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Electric Stimulation</subject><subject>Excitatory Postsynaptic Potentials - drug effects</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hippocampus - drug effects</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Neural Pathways - drug effects</subject><subject>Neural Pathways - physiology</subject><subject>Nootropic Agents - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Species Specificity</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Synaptic plasticity</subject><subject>Tenuigenin</subject><subject>Time Factors</subject><subject>Treatments</subject><subject>Y-maze learning task</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE2LFDEQhoMo7jj6A7xILoKXHisf3engSZbVFRa8rAdPoTpdvZuhOz0mPQPjrzfDjHpbKHgJPPWmeBh7K2AjQDQft5uuSxsJQm2gDIhnbCVaIytTa_ucrQrTVFrJ9oq9ynkLABpq8ZJdSaWtNSBXDO8p7sMDxRD5kgiXieLCw7RL84Ey7-gRD2FOOPKf1YS_iY-EqcAPvDtyio8Y_emRjxF3S_B8N2IuGZYjL41T8PSavRhwzPTmkmv248vN_fVtdff967frz3eVV61aKpQNWQRpW6G9aqS2uq2Vr6Xp20EqYwaDg1WKvCJsUVHT6n4wgKA7aKxUa_bh3FtO_7WnvLgpZE_jiJHmfXZClX8s1GAKKs6oT3POiQa3S2HCdHQC3Mms27pi1p3MOihTcs3eXer33UT9v42_Kgvw_gJg9jgO6aQm_-eMkkLppnCfzhwVGYdAyWUfKHrqQyK_uH4OT5zxB_3Lllo</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Huang, Jun-ni</creator><creator>Wang, Chun-yang</creator><creator>Wang, Xiu-li</creator><creator>Wu, Bo-zhi</creator><creator>Gu, Xing-yang</creator><creator>Liu, Wen-xiao</creator><creator>Gong, Liang-wei</creator><creator>Xiao, Peng</creator><creator>Li, Chu-hua</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice</title><author>Huang, Jun-ni ; Wang, Chun-yang ; Wang, Xiu-li ; Wu, Bo-zhi ; Gu, Xing-yang ; Liu, Wen-xiao ; Gong, Liang-wei ; Xiao, Peng ; Li, Chu-hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-a26e9a029814c362494853c527d8f2377f7af933ec3ea8a3e684df70a04b06923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>AChE activity</topic><topic>Animals</topic><topic>Antioxidation</topic><topic>Behavior therapy. Cognitive therapy</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Discrimination Learning - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Electric Stimulation</topic><topic>Excitatory Postsynaptic Potentials - drug effects</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hippocampus - drug effects</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Neural Pathways - drug effects</topic><topic>Neural Pathways - physiology</topic><topic>Nootropic Agents - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Species Specificity</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Synaptic plasticity</topic><topic>Tenuigenin</topic><topic>Time Factors</topic><topic>Treatments</topic><topic>Y-maze learning task</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Jun-ni</creatorcontrib><creatorcontrib>Wang, Chun-yang</creatorcontrib><creatorcontrib>Wang, Xiu-li</creatorcontrib><creatorcontrib>Wu, Bo-zhi</creatorcontrib><creatorcontrib>Gu, Xing-yang</creatorcontrib><creatorcontrib>Liu, Wen-xiao</creatorcontrib><creatorcontrib>Gong, Liang-wei</creatorcontrib><creatorcontrib>Xiao, Peng</creatorcontrib><creatorcontrib>Li, Chu-hua</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Jun-ni</au><au>Wang, Chun-yang</au><au>Wang, Xiu-li</au><au>Wu, Bo-zhi</au><au>Gu, Xing-yang</au><au>Liu, Wen-xiao</au><au>Gong, Liang-wei</au><au>Xiao, Peng</au><au>Li, Chu-hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>246</volume><spage>111</spage><epage>115</epage><pages>111-115</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>•Tenuigenin improves Y-maze learning performance in mice.•Tenuigenin enhances synaptic plasticity in hippocampal Schaffer-CA1 pathway.•Tenuigenin increases antioxidantive effect in hippocampus.•Tenuigenin inhibits hippocampal AChE activity.
Polygala tenuifolia root has been used to improve memory and cognitive function in Traditional Chinese Medicine for more than 2000 years. Since tenuigenin (TEN) is one of the most utilized P. tenuifolia root extracts, it is surprising there is no evidence for the effects of TEN on learning and memory so far. In the present study, we investigated the effects of TEN on learning and memory with Y-maze test in mice. We found that oral administration of 4mg/kg TEN significantly improved learning and memory in Y-maze task. Treatment with 4mg/kg TEN markedly reduced the acetylcholinesterase (AChE) activity and malondialdehyde (MDA) level, and increased superoxide dismutase (SOD) activity in hippocampus. In the electrophysiological test of hippocampal brain slice, 2μg/ml TEN perfusion substantially enhanced field excitatory postsynaptic potential (fEPSP) amplitude both in basic synaptic transmission and after high frequency stimulation (HFS) in Schaffer to CA1 pathway (Scha-CA1). These results indicate that TEN enhancing learning and memory may result from inhibiting AChE activity, improving antioxidation and enhancing synaptic plasticity in mice. Therefore, TEN shows promise as a potential nootropic product in improving learning and memory.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>23499702</pmid><doi>10.1016/j.bbr.2013.03.001</doi><tpages>5</tpages></addata></record> |
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| subjects | Acetylcholinesterase - metabolism AChE activity Animals Antioxidation Behavior therapy. Cognitive therapy Behavioral psychophysiology Biological and medical sciences Discrimination Learning - drug effects Dose-Response Relationship, Drug Drugs, Chinese Herbal - pharmacology Electric Stimulation Excitatory Postsynaptic Potentials - drug effects Fundamental and applied biological sciences. Psychology Hippocampus - drug effects In Vitro Techniques Male Malondialdehyde - metabolism Maze Learning - drug effects Medical sciences Memory - drug effects Mice Mice, Inbred Strains Neural Pathways - drug effects Neural Pathways - physiology Nootropic Agents - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Species Specificity Superoxide Dismutase - metabolism Synaptic plasticity Tenuigenin Time Factors Treatments Y-maze learning task |
| title | Tenuigenin treatment improves behavioral Y-maze learning by enhancing synaptic plasticity in mice |
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