Adipose Stem Cell Tissue–Engineered Construct Used to Treat Large Anterior Mandibular Defect: A Case Report and Review of the Clinical Application of Good Manufacturing Practice–Level Adipose Stem Cells for Bone Regeneration

Purpose Large mandibular resection defects historically have been treated using autogenous bone grafts and reconstruction plates. However, a major drawback of large autogenous bone grafts is donor-site morbidity. Patients and Methods This report describes the replacement of a 10-cm anterior mandibul...

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Veröffentlicht in:	Journal of oral and maxillofacial surgery 2013-05, Vol.71 (5), p.938-950
Hauptverfasser:	Sándor, George K., MD, DDS, PhD, Tuovinen, Veikko J., DDS, Wolff, Jan, DDS, PhD, Patrikoski, Mimmi, PhD, Jokinen, Jari, DDS, Nieminen, Elina, MD, Mannerström, Bettina, PhD, Lappalainen, Olli-Pekka, MD, DDS, Seppänen, Riitta, MD, DDS, PhD, Miettinen, Susanna, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Ameloblastoma - surgery Bone Morphogenetic Protein 2 - therapeutic use Bone Plates Bone Regeneration - physiology Bone Substitutes - therapeutic use Calcium Phosphates - therapeutic use Cell Culture Techniques Cell Differentiation - physiology Cell Survival - physiology Dental Implants Dental Prosthesis, Implant-Supported Dentistry Denture, Overlay Denture, Partial Follow-Up Studies Humans Male Mandibular Neoplasms - surgery Middle Aged Neoplasm Recurrence, Local - surgery Osseointegration - physiology Osteogenesis - physiology Recombinant Proteins - therapeutic use Reconstructive Surgical Procedures - methods Stem Cells - physiology Subcutaneous Fat, Abdominal - cytology Surgery Surgical Mesh Tissue Engineering - instrumentation Tissue Engineering - standards Tissue Scaffolds Transforming Growth Factor beta - therapeutic use
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