Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard
Background & Aims Real-time shear wave elastography (SWE) is a new two-dimensional transient elastography which had no assessment of factors associated with reliability, and had limited comparisons with other validated fibrosis biomarkers. The aim was to assess the applicability and performances...
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| Veröffentlicht in: | Journal of hepatology 2013-05, Vol.58 (5), p.928-935 |
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| creator | Poynard, Thierry Munteanu, Mona Luckina, Elena Perazzo, Hugo Ngo, Yen Royer, Luca Fedchuk, Larysa Sattonnet, Florence Pais, Raluca Lebray, Pascal Rudler, Marika Thabut, Dominique Ratziu, Vlad |
| description | Background & Aims Real-time shear wave elastography (SWE) is a new two-dimensional transient elastography which had no assessment of factors associated with reliability, and had limited comparisons with other validated fibrosis biomarkers. The aim was to assess the applicability and performances of SWE for the diagnosis of fibrosis as compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using two probes (TE-M and TE-XL). Methods Without a gold standard, the strength of concordance, discordance analysis and latent class analysis (LCM) were applied. Results 422 patients were included. The applicability of SWE (90.0%) was significantly lower than that of FT (97.9%; p |
| doi_str_mv | 10.1016/j.jhep.2012.12.021 |
| format | Article |
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The aim was to assess the applicability and performances of SWE for the diagnosis of fibrosis as compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using two probes (TE-M and TE-XL). Methods Without a gold standard, the strength of concordance, discordance analysis and latent class analysis (LCM) were applied. Results 422 patients were included. The applicability of SWE (90.0%) was significantly lower than that of FT (97.9%; p <0.0001) and did not differ from those of TE-M (90.5%) and TE-XL (90.3%); it was higher though for SWE (86%) in 22 patients with ascites vs. 55% using TE-M ( p = 0.04). For the diagnosis of all fibrosis stages as presumed by FT, the performance of SWE was highly significant (Obuchowski measure 0.807 ± 0.013 [m ± se]), but lower than those of TE-M (0.852; p = 0.0007) and TE-XL (0.834; p = 0.046). SWE had a low performance for discrimination between F0 and F1. For the diagnosis of cirrhosis using LCM, SWE specificities were all equal to 99%, and SWE sensitivities ranged from 0.47 to 0.64. For the diagnosis of non-cirrhotic stages, the results were heterogeneous. Conclusions The performance of SWE for the diagnosis of cirrhosis was similar to those of FT and TE. SWE applicability was lower than that of FT, but greater than that of TE in patients with ascites.</description><identifier>ISSN: 0168-8278</identifier><identifier>EISSN: 1600-0641</identifier><identifier>DOI: 10.1016/j.jhep.2012.12.021</identifier><identifier>PMID: 23321316</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aixplorer ; Concordance ; Elasticity Imaging Techniques - methods ; Female ; FibroScan ; Fibrosis ; FibroSure ; FibroTest ; Gastroenterology and Hepatology ; Humans ; Liver - physiopathology ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - physiopathology ; Male ; Middle Aged ; Non-invasive methods ; Obuchowski measure ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>Journal of hepatology, 2013-05, Vol.58 (5), p.928-935</ispartof><rights>European Association for the Study of the Liver</rights><rights>2013 European Association for the Study of the Liver</rights><rights>Copyright © 2013 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-cf530e58501e24d89c1556835f2704056ca1c2bc30f240c1cb7e93d80b49842f3</citedby><cites>FETCH-LOGICAL-c477t-cf530e58501e24d89c1556835f2704056ca1c2bc30f240c1cb7e93d80b49842f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168827813000081$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23321316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Poynard, Thierry</creatorcontrib><creatorcontrib>Munteanu, Mona</creatorcontrib><creatorcontrib>Luckina, Elena</creatorcontrib><creatorcontrib>Perazzo, Hugo</creatorcontrib><creatorcontrib>Ngo, Yen</creatorcontrib><creatorcontrib>Royer, Luca</creatorcontrib><creatorcontrib>Fedchuk, Larysa</creatorcontrib><creatorcontrib>Sattonnet, Florence</creatorcontrib><creatorcontrib>Pais, Raluca</creatorcontrib><creatorcontrib>Lebray, Pascal</creatorcontrib><creatorcontrib>Rudler, Marika</creatorcontrib><creatorcontrib>Thabut, Dominique</creatorcontrib><creatorcontrib>Ratziu, Vlad</creatorcontrib><title>Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard</title><title>Journal of hepatology</title><addtitle>J Hepatol</addtitle><description>Background & Aims Real-time shear wave elastography (SWE) is a new two-dimensional transient elastography which had no assessment of factors associated with reliability, and had limited comparisons with other validated fibrosis biomarkers. The aim was to assess the applicability and performances of SWE for the diagnosis of fibrosis as compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using two probes (TE-M and TE-XL). Methods Without a gold standard, the strength of concordance, discordance analysis and latent class analysis (LCM) were applied. Results 422 patients were included. The applicability of SWE (90.0%) was significantly lower than that of FT (97.9%; p <0.0001) and did not differ from those of TE-M (90.5%) and TE-XL (90.3%); it was higher though for SWE (86%) in 22 patients with ascites vs. 55% using TE-M ( p = 0.04). For the diagnosis of all fibrosis stages as presumed by FT, the performance of SWE was highly significant (Obuchowski measure 0.807 ± 0.013 [m ± se]), but lower than those of TE-M (0.852; p = 0.0007) and TE-XL (0.834; p = 0.046). SWE had a low performance for discrimination between F0 and F1. For the diagnosis of cirrhosis using LCM, SWE specificities were all equal to 99%, and SWE sensitivities ranged from 0.47 to 0.64. For the diagnosis of non-cirrhotic stages, the results were heterogeneous. Conclusions The performance of SWE for the diagnosis of cirrhosis was similar to those of FT and TE. SWE applicability was lower than that of FT, but greater than that of TE in patients with ascites.</description><subject>Aixplorer</subject><subject>Concordance</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Female</subject><subject>FibroScan</subject><subject>Fibrosis</subject><subject>FibroSure</subject><subject>FibroTest</subject><subject>Gastroenterology and Hepatology</subject><subject>Humans</subject><subject>Liver - physiopathology</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - physiopathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Non-invasive methods</subject><subject>Obuchowski measure</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0168-8278</issn><issn>1600-0641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2LFDEUDKK4s6t_wIPk6KXHl6Q_RYRlWVdhwIN6Dun065m06U6bpGeZn-E_Ns2MHjwID-pSVfCqipBXDLYMWPl22A4HnLccGN-mA86ekA0rATIoc_aUbBKpzmpe1VfkOoQBAAQ0-XNyxYXgTLByQ37tzBE97U3rXTCB4lHZRUXjJroEM-2pR2WzaEak4YDK00d1RIpWhej2Xs2H0zt6O8_WaNUaa-KJqqmjnVH7yYVoNJ3R986PatJ4cRwxHlwX6KNJuESq6N7ZjoaYlMp3L8izXtmALy94Q75_vP929ynbfXn4fHe7y3ReVTHTfSEAi7oAhjzv6kazoihrUfS8ghyKUiumeasF9DwHzXRbYSO6Gtq8qXPeixvy5uw7e_dzwRDlaIJGa9WEbgmSCcGgbgrBE5WfqTqFFDz2cvZmVP4kGci1CjnItQq5ViHTpSqS6PXFf2lH7P5K_mSfCO_PBExfHg16GbTBlFNnPOooO2f-7__hH7m2Zko92B94wjC4xU8pP8lkSAL5dR3DugUm0g4gwW-QVbG3</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Poynard, Thierry</creator><creator>Munteanu, Mona</creator><creator>Luckina, Elena</creator><creator>Perazzo, Hugo</creator><creator>Ngo, Yen</creator><creator>Royer, Luca</creator><creator>Fedchuk, Larysa</creator><creator>Sattonnet, Florence</creator><creator>Pais, Raluca</creator><creator>Lebray, Pascal</creator><creator>Rudler, Marika</creator><creator>Thabut, Dominique</creator><creator>Ratziu, Vlad</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard</title><author>Poynard, Thierry ; Munteanu, Mona ; Luckina, Elena ; Perazzo, Hugo ; Ngo, Yen ; Royer, Luca ; Fedchuk, Larysa ; Sattonnet, Florence ; Pais, Raluca ; Lebray, Pascal ; Rudler, Marika ; Thabut, Dominique ; Ratziu, Vlad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-cf530e58501e24d89c1556835f2704056ca1c2bc30f240c1cb7e93d80b49842f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aixplorer</topic><topic>Concordance</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Female</topic><topic>FibroScan</topic><topic>Fibrosis</topic><topic>FibroSure</topic><topic>FibroTest</topic><topic>Gastroenterology and Hepatology</topic><topic>Humans</topic><topic>Liver - physiopathology</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - physiopathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Non-invasive methods</topic><topic>Obuchowski measure</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Poynard, Thierry</creatorcontrib><creatorcontrib>Munteanu, Mona</creatorcontrib><creatorcontrib>Luckina, Elena</creatorcontrib><creatorcontrib>Perazzo, Hugo</creatorcontrib><creatorcontrib>Ngo, Yen</creatorcontrib><creatorcontrib>Royer, Luca</creatorcontrib><creatorcontrib>Fedchuk, Larysa</creatorcontrib><creatorcontrib>Sattonnet, Florence</creatorcontrib><creatorcontrib>Pais, Raluca</creatorcontrib><creatorcontrib>Lebray, Pascal</creatorcontrib><creatorcontrib>Rudler, Marika</creatorcontrib><creatorcontrib>Thabut, Dominique</creatorcontrib><creatorcontrib>Ratziu, Vlad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Poynard, Thierry</au><au>Munteanu, Mona</au><au>Luckina, Elena</au><au>Perazzo, Hugo</au><au>Ngo, Yen</au><au>Royer, Luca</au><au>Fedchuk, Larysa</au><au>Sattonnet, Florence</au><au>Pais, Raluca</au><au>Lebray, Pascal</au><au>Rudler, Marika</au><au>Thabut, Dominique</au><au>Ratziu, Vlad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard</atitle><jtitle>Journal of hepatology</jtitle><addtitle>J Hepatol</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>58</volume><issue>5</issue><spage>928</spage><epage>935</epage><pages>928-935</pages><issn>0168-8278</issn><eissn>1600-0641</eissn><abstract>Background & Aims Real-time shear wave elastography (SWE) is a new two-dimensional transient elastography which had no assessment of factors associated with reliability, and had limited comparisons with other validated fibrosis biomarkers. The aim was to assess the applicability and performances of SWE for the diagnosis of fibrosis as compared with FibroTest (FT) and liver stiffness measurement (LSM) by transient elastography using two probes (TE-M and TE-XL). Methods Without a gold standard, the strength of concordance, discordance analysis and latent class analysis (LCM) were applied. Results 422 patients were included. The applicability of SWE (90.0%) was significantly lower than that of FT (97.9%; p <0.0001) and did not differ from those of TE-M (90.5%) and TE-XL (90.3%); it was higher though for SWE (86%) in 22 patients with ascites vs. 55% using TE-M ( p = 0.04). For the diagnosis of all fibrosis stages as presumed by FT, the performance of SWE was highly significant (Obuchowski measure 0.807 ± 0.013 [m ± se]), but lower than those of TE-M (0.852; p = 0.0007) and TE-XL (0.834; p = 0.046). SWE had a low performance for discrimination between F0 and F1. For the diagnosis of cirrhosis using LCM, SWE specificities were all equal to 99%, and SWE sensitivities ranged from 0.47 to 0.64. For the diagnosis of non-cirrhotic stages, the results were heterogeneous. Conclusions The performance of SWE for the diagnosis of cirrhosis was similar to those of FT and TE. SWE applicability was lower than that of FT, but greater than that of TE in patients with ascites.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>23321316</pmid><doi>10.1016/j.jhep.2012.12.021</doi><tpages>8</tpages></addata></record> |
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| subjects | Aixplorer Concordance Elasticity Imaging Techniques - methods Female FibroScan Fibrosis FibroSure FibroTest Gastroenterology and Hepatology Humans Liver - physiopathology Liver Cirrhosis - diagnosis Liver Cirrhosis - physiopathology Male Middle Aged Non-invasive methods Obuchowski measure Reproducibility of Results Sensitivity and Specificity |
| title | Liver fibrosis evaluation using real-time shear wave elastography: Applicability and diagnostic performance using methods without a gold standard |
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