Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis

Background & Aims We evaluated the gastrointestinal permeability and bacterial translocation in cirrhotic patients with portal hypertension (PHT) prior to and after non-selective betablocker (NSBB) treatment. Methods Hepatic venous pressure gradient (HVPG) was measured prior to and under NSBB tr...

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Veröffentlicht in:	Journal of hepatology 2013-05, Vol.58 (5), p.911-921
Hauptverfasser:	Reiberger, Thomas, Ferlitsch, Arnulf, Payer, Berit A, Mandorfer, Mattias, Heinisch, Birgit B, Hayden, Hubert, Lammert, Frank, Trauner, Michael, Peck-Radosavljevic, Markus, Vogelsang, Harald
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-Phase Proteins Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Adult Aged Antigliadin antibodies Bacterial translocation Bacterial Translocation - drug effects Bacterial Translocation - physiology Carrier Proteins - blood Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Comorbidity Female Follow-Up Studies Gastroduodenal permeability Gastroenterology and Hepatology Hemodynamics - drug effects Hemodynamics - physiology Hepatic venous pressure gradient Humans HVPG Hypertension, Portal - drug therapy Hypertension, Portal - epidemiology Hypertension, Portal - metabolism Interleukin-6 - blood Intestinal Absorption - drug effects Intestinal Absorption - physiology Intestinal permeability Kaplan-Meier Estimate Lactulose - metabolism Liver Cirrhosis - drug therapy Liver Cirrhosis - epidemiology Liver Cirrhosis - metabolism Male Mannitol - metabolism Membrane Glycoproteins - blood Middle Aged NOD2 Sucrose - metabolism TLR2
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