Transcriptional regulation of human ferredoxin 1 in ovarian granulosa cells

► cAMP stimulation rapidly increases the expression of FDX1 in the rat ovarian granulosa cells. ► In differentiated hMSCs, SF-1 binds to the promoter of FDX1. ► Two SF-1 binding sites and a CRE-like sequence affect the FDX1 promoter activity. ► NR5A family and cAMP synergistically activate transcrip...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-05, Vol.370 (1-2), p.1-10
Hauptverfasser:	Imamichi, Yoshitaka, Mizutani, Tetsuya, Ju, Yunfeng, Matsumura, Takehiro, Kawabe, Shinya, Kanno, Masafumi, Yazawa, Takashi, Miyamoto, Kaoru
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Bromo Cyclic Adenosine Monophosphate - pharmacology Adrenodoxin - genetics Animals binding sites Cell Differentiation Cell Line, Tumor Cyclic AMP - metabolism DNA-Binding Proteins - metabolism Female Ferredoxin 1 Ferredoxins - biosynthesis Ferredoxins - genetics Gene Expression Regulation granulosa cells Granulosa Cells - metabolism HeLa Cells Humans liver Liver receptor homolog-1 luciferase Mesenchymal Stromal Cells - metabolism Ovarian granulosa cells progesterone Progesterone - biosynthesis Promoter Regions, Genetic Protein Binding Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear - metabolism RNA Interference RNA, Small Interfering Signal Transduction stem cells steroid hormones Steroidogenesis Steroidogenic Factor 1 - drug effects Steroidogenic Factor 1 - metabolism Steroidogenic factor-1 tissues transcription (genetics) Transcription, Genetic Transcriptional regulation
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