Molecular characterization of prolactin receptor (cPRLR) gene in chickens: Gene structure, tissue expression, promoter analysis, and its interaction with chicken prolactin (cPRL) and prolactin-like protein (cPRL-L)

•The unique gene structure of chicken PRLR (cPRLR) was revealed.•Two types of cPRLR transcripts with distinct tissue expression patterns were found.•cPRLR gene transcription is controlled by multiple promoters.•cPRL-L is a novel functional ligand of cPRLR.•Membrane-proximal ligand-binding domain of...

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Veröffentlicht in:	Molecular and cellular endocrinology 2013-05, Vol.370 (1-2), p.149-162
Hauptverfasser:	Bu, Guixian, Ying Wang, Crystal, Cai, Guoqing, Leung, Frederick C., Xu, Min, Wang, Hongning, Huang, Guian, Li, Juan, Wang, Yajun
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Untranslated Regions - genetics adults Amino Acid Sequence Animals Cell Line, Tumor Chick Embryo Chicken Chickens exons Gene Expression genes HEK293 Cells Hep G2 Cells human cell lines Humans Intestines - cytology Kidney - cytology kidneys liver Liver - cytology mammals Molecular Sequence Data Nucleic Acid Amplification Techniques Pregnancy Proteins - metabolism PRL PRLR prolactin Prolactin - metabolism prolactin receptors Prolactin-like protein Promoter Regions, Genetic Real-Time Polymerase Chain Reaction - veterinary Receptors, Prolactin - genetics Receptors, Prolactin - metabolism reverse transcriptase polymerase chain reaction RNA, Messenger - analysis RNA, Messenger - genetics small intestine Tissue expression tissues
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