Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study
Abstract Objectives The effects of ethnicity and gender can produce varying results when evaluating risk of chronic kidney disease (CKD) development and metabolic syndrome (MetS) components. The risks of specific MetS component combinations and incident CKD are unclear. The aim of this study was to...
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| Veröffentlicht in: | Maturitas 2013-05, Vol.75 (1), p.74-80 |
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| creator | Cho, Jeong Ae Lee, Sun Ju Reid, Easton A Jee, Sun Ha |
| description | Abstract Objectives The effects of ethnicity and gender can produce varying results when evaluating risk of chronic kidney disease (CKD) development and metabolic syndrome (MetS) components. The risks of specific MetS component combinations and incident CKD are unclear. The aim of this study was to investigate the relationship between the combination of MetS components and CKD. Methods This prospective cohort study included 15,401 participants. Koreans 20–84 years of age were followed for 5.2 years. The NCEP-ATP III definition of MetS was used. CKD was defined as an estimated glomerular filtration rate of |
| doi_str_mv | 10.1016/j.maturitas.2013.02.006 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1331087517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378512213000510</els_id><sourcerecordid>1331087517</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-f42a404b9c7c6125b85ee691591ebac16e007602e7106f8d50f80176f8b636d83</originalsourceid><addsrcrecordid>eNqNkk1v1DAQhiMEokvhL0AuSFyyzMSxneWAVFV8SUUcKGfj2BOtt4m92Eml_Hsc7VIkTpw8h2dej56ZoniFsEVA8fawHfU0RzfptK0B2RbqLYB4VGywlaxqEPFxsQEm24pjXV8Uz1I6AAAH1jwtLmrWtDvOcVP8_EqT7sLgTJkWb2MYqTRhPAZPflqrznk9ueBTqb0tzT4Gn9k7Zz0tpXWJdKJ35e2eykT3FLU3a8A-xKlM02yX58WTXg-JXpzfy-LHxw-315-rm2-fvlxf3VSm4WKq-qbWDTTdzkgjsOZdy4nEDvkOqdMGBQFIATVJBNG3lkPfAspcdoIJ27LL4s0p9xjDr5nSpEaXDA2D9hTmpJAxhFZylBmVJ9TEkFKkXh2jG3VcFIJa9aqDetCrVr0KapX15s6X50_mbiT70PfHZwZenwGdjB761YdLfznJQLZinfbqxFFWcu8oqmQcZXfWRTKTssH9xzDv_8kwg8vL0cMdLZQOYY4-G1eoUm5Q39drWI8B2XoICOw3Goeydw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1331087517</pqid></control><display><type>article</type><title>Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cho, Jeong Ae ; Lee, Sun Ju ; Reid, Easton A ; Jee, Sun Ha</creator><creatorcontrib>Cho, Jeong Ae ; Lee, Sun Ju ; Reid, Easton A ; Jee, Sun Ha</creatorcontrib><description>Abstract Objectives The effects of ethnicity and gender can produce varying results when evaluating risk of chronic kidney disease (CKD) development and metabolic syndrome (MetS) components. The risks of specific MetS component combinations and incident CKD are unclear. The aim of this study was to investigate the relationship between the combination of MetS components and CKD. Methods This prospective cohort study included 15,401 participants. Koreans 20–84 years of age were followed for 5.2 years. The NCEP-ATP III definition of MetS was used. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2 by the simplified Modification of Diet in Renal Disease equation. Results The incidence rate per 1000 person-years of CKD was determined in men (13.8) and women (14.1) with MetS. In a multivariate Cox proportional hazard model controlling for age and lifestyle variables, increased CKD risk in men (hazard ratio 1.45, 95% confidence interval 1.20–1.76) and women (1.52, 1.19–1.93) with Mets was found compared to those without MetS. Incidence and HRs for CKD elevated with increasing numbers of MetS components in men and women ( P for trend <0.0001). The risks associated with MetS varied by combination of causative factors. High blood pressure (BP) and low high-density lipoprotein (HDL) were more likely to be associated with risk of CKD development. Conclusions BP and HDL were the leading risk factors for CKD development in healthy Koreans. The association between MetS and kidney dysfunction were significantly independent of traditional cardiovascular risk factors.</description><identifier>ISSN: 0378-5122</identifier><identifier>EISSN: 1873-4111</identifier><identifier>DOI: 10.1016/j.maturitas.2013.02.006</identifier><identifier>PMID: 23489551</identifier><identifier>CODEN: MATUDK</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Blood pressure ; Chronic kidney disease ; Cohort study ; Epidemiology ; Female ; Gynecology. Andrology. Obstetrics ; High-density lipoprotein ; Humans ; Internal Medicine ; Kidneys ; Male ; Medical sciences ; Metabolic diseases ; Metabolic syndrome ; Metabolic Syndrome - epidemiology ; Middle Aged ; Miscellaneous ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Obstetrics and Gynecology ; Other metabolic disorders ; Prospective Studies ; Puberal and climacteric disorders (male and female) ; Renal failure ; Renal Insufficiency, Chronic - epidemiology ; Republic of Korea - epidemiology ; Risk Factors ; Urinary system involvement in other diseases. Miscellaneous ; Young Adult</subject><ispartof>Maturitas, 2013-05, Vol.75 (1), p.74-80</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f42a404b9c7c6125b85ee691591ebac16e007602e7106f8d50f80176f8b636d83</citedby><cites>FETCH-LOGICAL-c456t-f42a404b9c7c6125b85ee691591ebac16e007602e7106f8d50f80176f8b636d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.maturitas.2013.02.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27307868$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23489551$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cho, Jeong Ae</creatorcontrib><creatorcontrib>Lee, Sun Ju</creatorcontrib><creatorcontrib>Reid, Easton A</creatorcontrib><creatorcontrib>Jee, Sun Ha</creatorcontrib><title>Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study</title><title>Maturitas</title><addtitle>Maturitas</addtitle><description>Abstract Objectives The effects of ethnicity and gender can produce varying results when evaluating risk of chronic kidney disease (CKD) development and metabolic syndrome (MetS) components. The risks of specific MetS component combinations and incident CKD are unclear. The aim of this study was to investigate the relationship between the combination of MetS components and CKD. Methods This prospective cohort study included 15,401 participants. Koreans 20–84 years of age were followed for 5.2 years. The NCEP-ATP III definition of MetS was used. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2 by the simplified Modification of Diet in Renal Disease equation. Results The incidence rate per 1000 person-years of CKD was determined in men (13.8) and women (14.1) with MetS. In a multivariate Cox proportional hazard model controlling for age and lifestyle variables, increased CKD risk in men (hazard ratio 1.45, 95% confidence interval 1.20–1.76) and women (1.52, 1.19–1.93) with Mets was found compared to those without MetS. Incidence and HRs for CKD elevated with increasing numbers of MetS components in men and women ( P for trend <0.0001). The risks associated with MetS varied by combination of causative factors. High blood pressure (BP) and low high-density lipoprotein (HDL) were more likely to be associated with risk of CKD development. Conclusions BP and HDL were the leading risk factors for CKD development in healthy Koreans. The association between MetS and kidney dysfunction were significantly independent of traditional cardiovascular risk factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Blood pressure</subject><subject>Chronic kidney disease</subject><subject>Cohort study</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>High-density lipoprotein</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Obstetrics and Gynecology</subject><subject>Other metabolic disorders</subject><subject>Prospective Studies</subject><subject>Puberal and climacteric disorders (male and female)</subject><subject>Renal failure</subject><subject>Renal Insufficiency, Chronic - epidemiology</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Young Adult</subject><issn>0378-5122</issn><issn>1873-4111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1v1DAQhiMEokvhL0AuSFyyzMSxneWAVFV8SUUcKGfj2BOtt4m92Eml_Hsc7VIkTpw8h2dej56ZoniFsEVA8fawHfU0RzfptK0B2RbqLYB4VGywlaxqEPFxsQEm24pjXV8Uz1I6AAAH1jwtLmrWtDvOcVP8_EqT7sLgTJkWb2MYqTRhPAZPflqrznk9ueBTqb0tzT4Gn9k7Zz0tpXWJdKJ35e2eykT3FLU3a8A-xKlM02yX58WTXg-JXpzfy-LHxw-315-rm2-fvlxf3VSm4WKq-qbWDTTdzkgjsOZdy4nEDvkOqdMGBQFIATVJBNG3lkPfAspcdoIJ27LL4s0p9xjDr5nSpEaXDA2D9hTmpJAxhFZylBmVJ9TEkFKkXh2jG3VcFIJa9aqDetCrVr0KapX15s6X50_mbiT70PfHZwZenwGdjB761YdLfznJQLZinfbqxFFWcu8oqmQcZXfWRTKTssH9xzDv_8kwg8vL0cMdLZQOYY4-G1eoUm5Q39drWI8B2XoICOw3Goeydw</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Cho, Jeong Ae</creator><creator>Lee, Sun Ju</creator><creator>Reid, Easton A</creator><creator>Jee, Sun Ha</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study</title><author>Cho, Jeong Ae ; Lee, Sun Ju ; Reid, Easton A ; Jee, Sun Ha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-f42a404b9c7c6125b85ee691591ebac16e007602e7106f8d50f80176f8b636d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Blood pressure</topic><topic>Chronic kidney disease</topic><topic>Cohort study</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>High-density lipoprotein</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Obstetrics and Gynecology</topic><topic>Other metabolic disorders</topic><topic>Prospective Studies</topic><topic>Puberal and climacteric disorders (male and female)</topic><topic>Renal failure</topic><topic>Renal Insufficiency, Chronic - epidemiology</topic><topic>Republic of Korea - epidemiology</topic><topic>Risk Factors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cho, Jeong Ae</creatorcontrib><creatorcontrib>Lee, Sun Ju</creatorcontrib><creatorcontrib>Reid, Easton A</creatorcontrib><creatorcontrib>Jee, Sun Ha</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Maturitas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cho, Jeong Ae</au><au>Lee, Sun Ju</au><au>Reid, Easton A</au><au>Jee, Sun Ha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study</atitle><jtitle>Maturitas</jtitle><addtitle>Maturitas</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>75</volume><issue>1</issue><spage>74</spage><epage>80</epage><pages>74-80</pages><issn>0378-5122</issn><eissn>1873-4111</eissn><coden>MATUDK</coden><abstract>Abstract Objectives The effects of ethnicity and gender can produce varying results when evaluating risk of chronic kidney disease (CKD) development and metabolic syndrome (MetS) components. The risks of specific MetS component combinations and incident CKD are unclear. The aim of this study was to investigate the relationship between the combination of MetS components and CKD. Methods This prospective cohort study included 15,401 participants. Koreans 20–84 years of age were followed for 5.2 years. The NCEP-ATP III definition of MetS was used. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2 by the simplified Modification of Diet in Renal Disease equation. Results The incidence rate per 1000 person-years of CKD was determined in men (13.8) and women (14.1) with MetS. In a multivariate Cox proportional hazard model controlling for age and lifestyle variables, increased CKD risk in men (hazard ratio 1.45, 95% confidence interval 1.20–1.76) and women (1.52, 1.19–1.93) with Mets was found compared to those without MetS. Incidence and HRs for CKD elevated with increasing numbers of MetS components in men and women ( P for trend <0.0001). The risks associated with MetS varied by combination of causative factors. High blood pressure (BP) and low high-density lipoprotein (HDL) were more likely to be associated with risk of CKD development. Conclusions BP and HDL were the leading risk factors for CKD development in healthy Koreans. The association between MetS and kidney dysfunction were significantly independent of traditional cardiovascular risk factors.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>23489551</pmid><doi>10.1016/j.maturitas.2013.02.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Blood pressure Chronic kidney disease Cohort study Epidemiology Female Gynecology. Andrology. Obstetrics High-density lipoprotein Humans Internal Medicine Kidneys Male Medical sciences Metabolic diseases Metabolic syndrome Metabolic Syndrome - epidemiology Middle Aged Miscellaneous Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Obstetrics and Gynecology Other metabolic disorders Prospective Studies Puberal and climacteric disorders (male and female) Renal failure Renal Insufficiency, Chronic - epidemiology Republic of Korea - epidemiology Risk Factors Urinary system involvement in other diseases. Miscellaneous Young Adult |
| title | Metabolic syndrome component combinations and chronic kidney disease: The severance cohort study |
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