Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells

The critical step in colorectal cancer progression and associated mortality is cancer invasion, which depends on two key gelatinase enzymes, matrix metalloproteinases-2 and -9. Dried longan (Euphoria longana Lam.) seed is a rich natural source of antioxidant polyphenols.This study evaluated the effe...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2013-04, Vol.61 (15), p.3631-3641
Hauptverfasser:	Panyathep, Atita, Chewonarin, Teera, Taneyhill, Khanittha, Vinitketkumnuen, Usanee, Surh, Young-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences cell invasion Cell Line, Tumor Cell Survival - drug effects chelation chromatography Colonic Neoplasms - drug therapy Colonic Neoplasms - enzymology Colonic Neoplasms - pathology colorectal neoplasms Dimocarpus longan Food industries Fundamental and applied biological sciences. Psychology gelatinase A Humans Matrix Metalloproteinase 2 - chemistry Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - chemistry Matrix Metalloproteinase 9 - metabolism Matrix Metalloproteinase Inhibitors - chemistry Matrix Metalloproteinase Inhibitors - isolation & purification Matrix Metalloproteinase Inhibitors - pharmacology Matrix Metalloproteinases, Secreted - antagonists & inhibitors Matrix Metalloproteinases, Secreted - metabolism mitogen-activated protein kinase mortality Neoplasm Invasiveness - prevention & control Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Sapindaceae - chemistry seed extracts seeds Seeds - chemistry signal transduction zinc
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