In Vitro and In Vivo Inhibitory Activities of Four Indian Medicinal Plant Extracts and their Major Components on Rat Aldose Reductase and Generation of Advanced Glycation Endproducts
The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their princ...
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| Veröffentlicht in: | Phytotherapy research 2013-05, Vol.27 (5), p.753-760 |
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| creator | Rao, Ajmeera Rama Veeresham, Ciddi Asres, Kaleab |
| description | The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their principal components for AR inhibitory activity and to find out their influence in diabetic complications. Thus, Boswellia serrata Triana & Planch. (Burseraceae), Lagerstroemia speciosa (L.) Pers. (Lythraceae), Ocimum gratissimum (L.) (Lamiaceae) and Syzygium cumin (L.) Skeels. (Myrthaceae) and their respective major constituents, boswellic acid, corosolic acid, ursolic acid and ellagic acid, were studied for their inhibitory activity against rat lens AR, rat kidney AR, human recombinant AR and generation of AGEs. In addition, in vivo inhibition of lens galactitol accumulation by the major constituents of the plants in galactose‐fed rat has been studied. The results revealed that all the tested extracts and their active ingredients possess significant AR inhibitory actions in both in vitro and in vivo assays with urosolic acid showing the most potent effect. Furthermore, the study indicates the potential of the studied plants and their major constituents as possible protective agents against long‐term diabetic complications. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.4786 |
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The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their principal components for AR inhibitory activity and to find out their influence in diabetic complications. Thus, Boswellia serrata Triana & Planch. (Burseraceae), Lagerstroemia speciosa (L.) Pers. (Lythraceae), Ocimum gratissimum (L.) (Lamiaceae) and Syzygium cumin (L.) Skeels. (Myrthaceae) and their respective major constituents, boswellic acid, corosolic acid, ursolic acid and ellagic acid, were studied for their inhibitory activity against rat lens AR, rat kidney AR, human recombinant AR and generation of AGEs. In addition, in vivo inhibition of lens galactitol accumulation by the major constituents of the plants in galactose‐fed rat has been studied. The results revealed that all the tested extracts and their active ingredients possess significant AR inhibitory actions in both in vitro and in vivo assays with urosolic acid showing the most potent effect. Furthermore, the study indicates the potential of the studied plants and their major constituents as possible protective agents against long‐term diabetic complications. Copyright © 2012 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.4786</identifier><identifier>PMID: 22826152</identifier><identifier>CODEN: PHYREH</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>advanced glycation endproducts ; Aldehyde Reductase - antagonists & inhibitors ; aldose reductase ; Animals ; Boswellia - chemistry ; Ellagic Acid - pharmacology ; enzyme inhibition ; Galactitol - analysis ; galactitol accumulation ; Glycation End Products, Advanced - analysis ; Humans ; Kidney - drug effects ; Kidney - enzymology ; Lagerstroemia - chemistry ; Lens, Crystalline - drug effects ; Lens, Crystalline - enzymology ; Male ; Ocimum - chemistry ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Rats ; Rats, Wistar ; Recombinant Proteins - antagonists & inhibitors ; standardized plant extracts ; Syzygium - chemistry ; Triterpenes - pharmacology ; Ursolic Acid</subject><ispartof>Phytotherapy research, 2013-05, Vol.27 (5), p.753-760</ispartof><rights>Copyright © 2012 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3876-d65fb4d0058fc3c103321a7dd3aeefba194f6bc3a27b9fa9f78413c09ea2f6453</citedby><cites>FETCH-LOGICAL-c3876-d65fb4d0058fc3c103321a7dd3aeefba194f6bc3a27b9fa9f78413c09ea2f6453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.4786$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.4786$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22826152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rao, Ajmeera Rama</creatorcontrib><creatorcontrib>Veeresham, Ciddi</creatorcontrib><creatorcontrib>Asres, Kaleab</creatorcontrib><title>In Vitro and In Vivo Inhibitory Activities of Four Indian Medicinal Plant Extracts and their Major Components on Rat Aldose Reductase and Generation of Advanced Glycation Endproducts</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their principal components for AR inhibitory activity and to find out their influence in diabetic complications. Thus, Boswellia serrata Triana & Planch. (Burseraceae), Lagerstroemia speciosa (L.) Pers. (Lythraceae), Ocimum gratissimum (L.) (Lamiaceae) and Syzygium cumin (L.) Skeels. (Myrthaceae) and their respective major constituents, boswellic acid, corosolic acid, ursolic acid and ellagic acid, were studied for their inhibitory activity against rat lens AR, rat kidney AR, human recombinant AR and generation of AGEs. In addition, in vivo inhibition of lens galactitol accumulation by the major constituents of the plants in galactose‐fed rat has been studied. The results revealed that all the tested extracts and their active ingredients possess significant AR inhibitory actions in both in vitro and in vivo assays with urosolic acid showing the most potent effect. Furthermore, the study indicates the potential of the studied plants and their major constituents as possible protective agents against long‐term diabetic complications. Copyright © 2012 John Wiley & Sons, Ltd.</description><subject>advanced glycation endproducts</subject><subject>Aldehyde Reductase - antagonists & inhibitors</subject><subject>aldose reductase</subject><subject>Animals</subject><subject>Boswellia - chemistry</subject><subject>Ellagic Acid - pharmacology</subject><subject>enzyme inhibition</subject><subject>Galactitol - analysis</subject><subject>galactitol accumulation</subject><subject>Glycation End Products, Advanced - analysis</subject><subject>Humans</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>Lagerstroemia - chemistry</subject><subject>Lens, Crystalline - drug effects</subject><subject>Lens, Crystalline - enzymology</subject><subject>Male</subject><subject>Ocimum - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Recombinant Proteins - antagonists & inhibitors</subject><subject>standardized plant extracts</subject><subject>Syzygium - chemistry</subject><subject>Triterpenes - pharmacology</subject><subject>Ursolic Acid</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kdtuEzEQhi0EoqEg8QTIEjfcbOvD7nr3MkRpqNSWKgptxY3l9UF12NjB9obmxXi-Ok0oEhJXY898849mfgDeY3SCESKn6xROStbUL8AIo7YtcMXoSzBCbYWLEjd3R-BNjEuEUEtQ-RocEdKQGldkBH6fO3hjU_BQOAWfPhuf473tbPJhC8cy2Y1NVkfoDTzzQ8hVZYWDl1pZaZ3o4XUvXILThxSETPFJKd1rG-ClWPoAJ3619k67XPIOzkWC4175qOFcq0EmkV-7lpl2OohkM5MnjdVGOKlzut_KfXbq1Dr4XUt8C14Z0Uf97hCPwbez6WLypbj4OjufjC8KSRtWF6quTFcqhKrGSCoxopRgwZSiQmvTCdyWpu4kFYR1rRGtYU2JqUStFsTUZUWPwae9bh78c9Ax8ZWNUvd5Ye2HyDGlGDU1qlBGP_6DLvOx8nl2FGkwK9u2_isog48xaMPXwa5E2HKM-M5Lnr3kOy8z-uEgOHQrrZ7BP-ZloNgDv2yvt_8V4teL-UHwwNuY9MMzL8IPXjPKKn57NePfb9niCn--4zf0EUgPufI</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Rao, Ajmeera Rama</creator><creator>Veeresham, Ciddi</creator><creator>Asres, Kaleab</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201305</creationdate><title>In Vitro and In Vivo Inhibitory Activities of Four Indian Medicinal Plant Extracts and their Major Components on Rat Aldose Reductase and Generation of Advanced Glycation Endproducts</title><author>Rao, Ajmeera Rama ; Veeresham, Ciddi ; Asres, Kaleab</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3876-d65fb4d0058fc3c103321a7dd3aeefba194f6bc3a27b9fa9f78413c09ea2f6453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>advanced glycation endproducts</topic><topic>Aldehyde Reductase - antagonists & inhibitors</topic><topic>aldose reductase</topic><topic>Animals</topic><topic>Boswellia - chemistry</topic><topic>Ellagic Acid - pharmacology</topic><topic>enzyme inhibition</topic><topic>Galactitol - analysis</topic><topic>galactitol accumulation</topic><topic>Glycation End Products, Advanced - analysis</topic><topic>Humans</topic><topic>Kidney - drug effects</topic><topic>Kidney - enzymology</topic><topic>Lagerstroemia - chemistry</topic><topic>Lens, Crystalline - drug effects</topic><topic>Lens, Crystalline - enzymology</topic><topic>Male</topic><topic>Ocimum - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Recombinant Proteins - antagonists & inhibitors</topic><topic>standardized plant extracts</topic><topic>Syzygium - chemistry</topic><topic>Triterpenes - pharmacology</topic><topic>Ursolic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rao, Ajmeera Rama</creatorcontrib><creatorcontrib>Veeresham, Ciddi</creatorcontrib><creatorcontrib>Asres, Kaleab</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rao, Ajmeera Rama</au><au>Veeresham, Ciddi</au><au>Asres, Kaleab</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro and In Vivo Inhibitory Activities of Four Indian Medicinal Plant Extracts and their Major Components on Rat Aldose Reductase and Generation of Advanced Glycation Endproducts</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2013-05</date><risdate>2013</risdate><volume>27</volume><issue>5</issue><spage>753</spage><epage>760</epage><pages>753-760</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><coden>PHYREH</coden><abstract>The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabetes and related diseases, and their principal components for AR inhibitory activity and to find out their influence in diabetic complications. Thus, Boswellia serrata Triana & Planch. (Burseraceae), Lagerstroemia speciosa (L.) Pers. (Lythraceae), Ocimum gratissimum (L.) (Lamiaceae) and Syzygium cumin (L.) Skeels. (Myrthaceae) and their respective major constituents, boswellic acid, corosolic acid, ursolic acid and ellagic acid, were studied for their inhibitory activity against rat lens AR, rat kidney AR, human recombinant AR and generation of AGEs. In addition, in vivo inhibition of lens galactitol accumulation by the major constituents of the plants in galactose‐fed rat has been studied. The results revealed that all the tested extracts and their active ingredients possess significant AR inhibitory actions in both in vitro and in vivo assays with urosolic acid showing the most potent effect. Furthermore, the study indicates the potential of the studied plants and their major constituents as possible protective agents against long‐term diabetic complications. Copyright © 2012 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>22826152</pmid><doi>10.1002/ptr.4786</doi><tpages>8</tpages></addata></record> |
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| subjects | advanced glycation endproducts Aldehyde Reductase - antagonists & inhibitors aldose reductase Animals Boswellia - chemistry Ellagic Acid - pharmacology enzyme inhibition Galactitol - analysis galactitol accumulation Glycation End Products, Advanced - analysis Humans Kidney - drug effects Kidney - enzymology Lagerstroemia - chemistry Lens, Crystalline - drug effects Lens, Crystalline - enzymology Male Ocimum - chemistry Plant Extracts - pharmacology Plants, Medicinal - chemistry Rats Rats, Wistar Recombinant Proteins - antagonists & inhibitors standardized plant extracts Syzygium - chemistry Triterpenes - pharmacology Ursolic Acid |
| title | In Vitro and In Vivo Inhibitory Activities of Four Indian Medicinal Plant Extracts and their Major Components on Rat Aldose Reductase and Generation of Advanced Glycation Endproducts |
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