Interaction of IL-1β and P2X(3) receptor in pathologic masseter muscle pain

The exact mechanism underlying chronic masseter muscle pain, a conspicuous symptom in temporomandibular disorder, remains unclear. We investigated whether expression of P2X3 receptor (P2X3R) is involved in mechanical hyperalgesia after contraction of masseter muscle (CMM). As compared with sham rats...

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Veröffentlicht in:	Journal of dental research 2013-05, Vol.92 (5), p.456-460
Hauptverfasser:	Noma, N, Shinoda, M, Honda, K, Kiyomoto, M, Dezawa, K, Nakaya, Y, Komiyama, O, Imamura, Y, Iwata, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Dentistry Electric Stimulation Facial Neuralgia - complications Facial Neuralgia - metabolism Facial Neuralgia - physiopathology Hyperalgesia - complications Hyperalgesia - metabolism Hyperalgesia - physiopathology Interleukin-1beta - metabolism Male Masseter Muscle - metabolism Masseter Muscle - physiopathology Muscle Contraction - physiology Purinergic P2X Receptor Antagonists - pharmacokinetics Rats Rats, Sprague-Dawley Reaction Time - physiology Receptors, Interleukin - antagonists & inhibitors Receptors, Purinergic P2X3 - drug effects Receptors, Purinergic P2X3 - metabolism Temporomandibular Joint Dysfunction Syndrome - complications Temporomandibular Joint Dysfunction Syndrome - metabolism Temporomandibular Joint Dysfunction Syndrome - physiopathology
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